DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCR10 and TkR86C

DIOPT Version :9

Sequence 1:	NP_057686.2	Gene:	CCR10 / 2826	HGNCID:	4474	Length:	362	Species:	Homo sapiens
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	334	Identity:	90/334 - (26%)
Similarity:	157/334 - (47%)	Gaps:	41/334 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    54 LGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLL-ALTLPFAAAGALQG-WSLGSATCRTI 116
            :.:||||:||.. :...|:.|:.|:..||.|::||||: :|...|.....|.. |..||..|...
  Fly    96 VAIAGNGIVLWI-VTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFNFIFMLNSDWPFGSIYCTIN 159

Human   117 SGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQ 181
            :.:.:.:.......|..||.|||:||...|   .|.::..:..::.|::|.||.:|:.|.||:|.
  Fly   160 NFVANVTVSTSVFTLVAISFDRYIAIVHPL---KRRTSRRKVRIILVLIWALSCVLSAPCLLYSS 221

Human   182 DGQR---EGQRR--CRLIFPEGL--TQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARG 239
            ...:   .|:.|  |.:::|:|.  |.....|..:..:.|.:.:|:.||:.||:|:||.|..:|.
  Fly   222 IMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVMLICYSLMGRVLWGSRS 286

Human   240 ------------PERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVAL 292
                        ..:|:.:|:.:|:|:.|.:..|||.|..      :.|.......::|......
  Fly   287 IGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFF------IYAYHNNQVASTKYVQHMY 345

Human   293 LVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAP----- 352
            |....||::...:||::|.::..|||...:|::  ..|..|....|....:.||::.::.
  Fly   346 LGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRII--CCCCVGLTRHRFDSPKSRLTNKNSSNRHTR 408

Human   353 ---TETHSL 358
               |..|||
  Fly   409 GGYTVAHSL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCR10	NP_057686.2	7tm_GPCRs	42..321	CDD:333717	80/287 (28%)
		TM helix 1	44..68	CDD:320095	6/13 (46%)
		TM helix 2	78..99	CDD:320095	9/21 (43%)
		TM helix 3	114..136	CDD:320095	2/21 (10%)
		TM helix 4	160..176	CDD:320095	5/15 (33%)
		TM helix 5	205..228	CDD:320095	6/22 (27%)
		TM helix 6	243..268	CDD:320095	9/24 (38%)
		TM helix 7	289..314	CDD:320095	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..362		9/39 (23%)
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	80/289 (28%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	75/272 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6644
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860