DRSC/TRiP Functional Genomics Resources

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Protein Alignment Slco1b2 and Oatp58Da

DIOPT Version :9

Sequence 1:NP_065241.1 Gene:Slco1b2 / 28253 MGIID:1351899 Length:689 Species:Mus musculus
Sequence 2:NP_611657.2 Gene:Oatp58Da / 37543 FlyBaseID:FBgn0050277 Length:684 Species:Drosophila melanogaster


Alignment Length:692 Identity:180/692 - (26%)
Similarity:304/692 - (43%) Gaps:93/692 - (13%)


- Green bases have known domain annotations that are detailed below.


Mouse    18 KTRHCDGFRIF-------LAALSFSYICKALGGVIM-------KSSITQIERRFDIPSSISGLID 68
            |..:| ||.||       .|......|...|.|.:|       ..:||.:|:|:.||:.:||:|.
  Fly    45 KDTYC-GFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIIS 108

Mouse    69 GGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALPHFFMGYYRYATENDISSLH-- 131
            .|.:|..:|....:.|:....|||:.:|.|...:....:||:..||..|    |.|:.:....  
  Fly   109 VGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYG----AGEDALQLTREF 169

Mouse   132 ---NSTLTCLVNQTTSLTGTSPEIMEKGC---EKGSNSYTW---IYVLMGNMLRGIGETPIVPLG 187
               |.|||   ||........|  ...||   |.|    .|   :::....::.|:|:.....||
  Fly   170 GQVNETLT---NQERDKKLCQP--TAGGCVQEEVG----LWVPQVFLFAAQLISGVGQALFYTLG 225

Mouse   188 VSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGA 252
            ::|:||...:..:...|.....:.|:||.:|:.:::|..:||::.....|    |..:|.||:||
  Fly   226 IAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPL----IGQEDPRWLGA 286

Mouse   253 WWLGFIVNGLLCIICSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEKQAPANL 317
            ||||::|...:.::.:|..|..||....::|.|..      ||.||.|..:  |..:.     :|
  Fly   287 WWLGWLVLAAITLVSAILLFMFPKQLPSARKRRLQ------LKQDERKQSL--PLNER-----SL 338

Mouse   318 TGFLWSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMA 382
            ...:.:::.:..|:.||...:.::|....::..:.:..|:||.|:.|:|:.|....|.:.:...|
  Fly   339 ADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSA 403

Mouse   383 SGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVDSHI 447
            :|:.:.||:|.:.|.:...:..:......:.....|.|..:.||.........|....|.     
  Fly   404 AGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGSDRLNTLTTLSAGNS----- 463

Mouse   448 DVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNIEFYDCSCVSGSGFQKG 512
                  |::.|.||...:.|||..:.:|:||.|.||| |.|....|....:..|.|:..|.....
  Fly   464 ------CSASCHCDYVHYAPVCSADNITFISACHAGC-SERTKDALGRTIYTGCECLGSSSLNSE 521

Mouse   513 NHS--ARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVV 575
            ..|  |..|.||.| |..::..::.....:....|...::.:|:.:|.:.|:.|:..:|..|:..
  Fly   522 PESQFAVDGTCPVD-CFNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAA 585

Mouse   576 RTLGGILAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTPILL---LYV 637
            ..||.|.:|:::|.|||..|:.|..| |..:|.|.||:::  .|.| .|:::....|.|   |.:
  Fly   586 SLLGFIPSPIFFGWLIDNYCLVWGKT-CSNKGNCWLYDTK--SMRY-ALNLSAAFFIFLGGFLNI 646

Mouse   638 ALIYVMKRKMKRND-----------NKILENGRKFTDEGNPE 668
            |:.|..| .:|..|           ||.:|   ..|.:.|||
  Fly   647 AVWYHAK-NLKIFDEEESSPKDSLKNKEVE---MKTIDSNPE 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Slco1b2NP_065241.1 MFS 26..557 CDD:421695 137/557 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..689 4/11 (36%)
Oatp58DaNP_611657.2 OATP 67..626 CDD:281175 155/604 (26%)
MFS 69..>425 CDD:119392 99/385 (26%)
KAZAL_SLC21 462..514 CDD:238650 20/63 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3626
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1029129at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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