DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slco1a4 and Oatp58Dc

DIOPT Version :9

Sequence 1:	NP_001342506.1	Gene:	Slco1a4 / 28250	MGIID:	1351896	Length:	670	Species:	Mus musculus
Sequence 2:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	722	Identity:	191/722 - (26%)
Similarity:	305/722 - (42%)	Gaps:	129/722 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 FSKIKAFLL---ALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSVVGLINGSFEIGNLLLIIFVS 77
            |:...|::|   .:.|.:   |::..|.|..:|.||::|.||:...|:|:...:|...|:...::
  Fly   107 FANQTAYVLLYGIVGCIF---SMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLA 168

Mouse    78 YFGTKLHRPIMIGVGCAVMGLGCFLISIPHFLMGRYEYETTI------LPTSNLSSNSFVCTENR 136
            |:..|.|||..||.|...:...|.|.:.||||.|..|....:      :|..|.:..:.  .|.|
  Fly   169 YYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAI--EEQR 231

Mouse   137 TQTL-KPTQDPTEC-VKEMKSLMWIYVLVGNIIRGMGETPIMPLGISYIEDFAKSENSPLYIGIL 199
            ::|| :......|| |.|......:.:.|...|.|:|.:....||:||::|..|...:|..:.:.
  Fly   232 SKTLCRLNGGGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLS 296

Mouse   200 ETGMTIGPLIGLLLGSSCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFF 264
            .....:||.||..|.|.|..:|:    .......|...|.||:||||:|:||..|:...:.:...
  Fly   297 YFLRMLGPAIGYALASFCLRLYI----APQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLS 357

Mouse   265 FFPKTLLKEGLQDNGDGTENAKEEKHREKIKE----------------ENRGITKDFFLFMKSLS 313
            .|||.|.:...:...:  ||.:.||.|..:|.                |.:...:|.....:.|.
  Fly   358 MFPKELPRAVARRKVE--ENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRRLI 420

Mouse   314 CNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMK 378
            .|..||...|.|:..:..:...:.|.|||:|.||.:|.|....:.|...|....:|.|:.|.|:.
  Fly   421 TNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIIS 485

Mouse   379 KFKITVKKAAYIGFWLSLTEYL-------LSFV-------SYIMTCDNFPVAGLTTSYEGVQHPL 429
            ::|   .:|.|:..|..:..:|       .:|:       |.|:...:..:||.||:
  Fly   486 RYK---PRARYMAAWNVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDSSLAGNTTT-------- 539

Mouse   430 YVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCEK-SVGTGTNMVFQNCSCIQSS--- 490
                     ||:.|||....:.||||:|.::|:|||.|||:| .|.:....:|.:||||.|.
  Fly   540 ---------CNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAG 595

Mouse   491 --------------------------------GNASAVLGLCDKGPECANKLQYFLIISIIGCFI 523
                                            .|..|:.|.|.  ..|..:...||.:.....|:
  Fly   596 NSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACP--VNCWTQFVAFLAVMCCLKFV 658

Mouse   524 FSLGAIPGYMVLLRCMKSEEKSLGVGLHTFCMRILGGIPAPIYFGALIDRTCLHWGTLKCGEPGA 588
            .:.|....::|.:||:..::|:..:|.......:|..||:||:||.:.||.||.||. .|...|.
  Fly   659 GASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGK-TCTNKGN 722

Mouse   589 CRMYDINSFRRIYLGLPAALR-GASFLPALFILI----LMRKFQFPGDIDSSDTD--PAEMKLTA 646
            |.:||           |.::| ..:|..|:||.|    .:..:.:..|:...|.|  ..|||:..
  Fly   723 CWLYD-----------PLSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVKEVEMKIVQ 776

Mouse   647 KESKCTN 653
            .|.:..|
  Fly   777 HEEEANN 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slco1a4	NP_001342506.1	oat	1..625	CDD:273279	183/690 (27%)
Slco1a4	NP_001342506.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..670		1/5 (20%)
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	176/663 (27%)
		MFS	114..>518	CDD:119392	111/417 (27%)
		KAZAL_SLC21	537..590	CDD:238650	25/69 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820