DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slco1a4 and Oatp58Db

DIOPT Version :9

Sequence 1:	NP_001342506.1	Gene:	Slco1a4 / 28250	MGIID:	1351896	Length:	670	Species:	Mus musculus
Sequence 2:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	725	Identity:	182/725 - (25%)
Similarity:	305/725 - (42%)	Gaps:	129/725 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 EKEVATHGVRC------------FSKIKAFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSV 57
            ||.:.:....|            |:....|::....|....:::.||....:|.:|::|.|||.:
  Fly    25 EKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKI 89

Mouse    58 VGLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISIPHFLMGRYEYETTILPT 122
            .|||....:|..:....|:||:.::.|||..:.:|..::.:.|.|:..||...|..|....:...
  Fly    90 SGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEE 154

Mouse   123 SNLS-----------SNSFVCTENRTQTLKPTQDPTECVKEMKSLMWIYVLVGNIIRGMGETPIM 176
            ..:|           .|..:|.|..:..|:...|.|..|     |.:|...:|    |:|.:...
  Fly   155 YGMSESFGASLNITEKNDSLCHEKNSNCLERAGDYTPIV-----LFFIAQFIG----GIGCSLFY 210

Mouse   177 PLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLGSSCANIYVDTGSVNTDDLTITPTDTRW 241
            ..|:||::|.:.|..:|..:........:||.:|..:.|.|..:|:|.    .....||..|.||
  Fly   211 APGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYIDP----FKKPLITTNDPRW 271

Mouse   242 VGAWWIGFLVCAGVNILTSIPFFFFPKTLLK-EGLQDNGDGTENAKEEKHREKIKEENRGITKDF 305
            :||||||:::...:..::::....|||.:.: :..:...||.|:         |....|.. :|.
  Fly   272 MGAWWIGWILLTFILTISAVFVGMFPKEMPRAKARRLKADGEED---------IPLAGRSF-QDM 326

Mouse   306 FLFMKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGY 370
            ...:|.|:.|.:|:..:|.|::.:..::..:.|.|||:|.||.:|.:......|.:.|.....|.
  Fly   327 LDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSAAGI 391

Mouse   371 LIGGLIMKKFKITVKKAAYIGFWLSLTEYL--LSFVSYIMT-CDNFPVAGLTTSYEGVQHPLYVE 432
            ||.|.::.|:|.:.:..|   .|..:.:||  ...:.|::. ||....|
  Fly   392 LISGYVISKYKPSARAMA---AWNFVVDYLTVAGMLCYVLVGCDESDRA---------------- 437

Mouse   433 NNVLA------DCNTKCSCLTNTWDPVCGDNGLSYMSACLAGC-EKSVGTGTNMVFQNCSCIQSS 490
             |.|:      .|:..|.|....:.|||....::::|||.||| :|::......::..|.|:
  Fly   438 -NSLSIVPTGDSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRCM--- 498

Mouse   491 GNASAVL-----------------GLCDKGPECANKLQYFLIISIIGCFIFSLGAI---PGYMVL 535
            ||.|:::                 |.|   |...||  .|||...:.||:..:||.   ...::.
  Fly   499 GNVSSIISLSNVTSLASQSQIAMDGAC---PVDCNK--QFLIFLAVMCFLKFVGATGRSSNLLLA 558

Mouse   536 LRCMKSEEKSLGVGLHTFCMRILGGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRI 600
            |||:.|::|:..:|..:....:|..||:||.||.::|..||.||. .|...|.|.:||..|. |.
  Fly   559 LRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGK-TCSSKGNCWIYDTKSL-RY 621

Mouse   601 YLGLPAALRGASFLPALFILILMRKFQFPG------DIDSSDTDPAEMKLTAKESKCTNVHRSPT 659
            .:.|..|           .||.:..|...|      |:...|.|  |..:.||:|....:...|
  Fly   622 TMNLVCA-----------SLIFLGSFWNIGVWYHAKDMKVFDED--EKTVQAKQSDDIELKEKP- 672

Mouse   660 MQNDGERKTK 669
              ||...|.|
  Fly   673 --NDVVTKKK 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slco1a4	NP_001342506.1	oat	1..625	CDD:273279	168/673 (25%)
Slco1a4	NP_001342506.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..670		6/21 (29%)
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	158/617 (26%)
		MFS	55..>410	CDD:119392	95/380 (25%)
		KAZAL_SLC21	447..499	CDD:238650	15/54 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920