DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CMKLR2 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_001091669.1	Gene:	CMKLR2 / 2825	HGNCID:	4463	Length:	355	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	90/335 - (26%)
Similarity:	160/335 - (47%)	Gaps:	48/335 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     5 EETLF-EEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFT-GFKW 67
            ||:|: .:...|.:.:...:..:||           .::|||....::|:.||.:||:.. .|..
  Fly    54 EESLYGTDLPTYQHCIATRNSFADL-----------FTVVLYGFVCIIGLFGNTLVIYVVLRFSK 107

Human    68 KKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVIS 132
            .:|||.::.||||:||..||:.:| ::.|......|.||.::|||...:..:..|.|..||.::|
  Fly   108 MQTVTNIYILNLAVADECFLIGIP-FLLYTMRICSWRFGEFMCKAYMVSTSITSFTSSIFLLIMS 171

Human   133 LDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVE------FNNHTLCYNNF 191
            .|.||.:.||:.|.|:|||..:.:|....|..::::..|.:.:..|||      ::.:.:..:.:
  Fly   172 ADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLMLPVILYASTVEQEDGINYSCNIMWPDAY 236

Human   192 QKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKV-------------KKRSILISSR 243
            :||. ..|.|.:      .|.:|:..||..:...|..:|.|:             |:|:....:|
  Fly   237 KKHS-GTTFILY------TFFLGFATPLCFILSFYYLVIRKLRSVGPKPGTKSKEKRRAHRKVTR 294

Human   244 HFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGI---PLSTGLAFLNSCLNPILYV 305
               .:|.|:..:::||.|:.:..:  ..||.|.....:.:..|   .|...|.:.||.:|||||.
  Fly   295 ---LVLTVISVYILCWLPHWISQV--ALIHSNPAQRDLSRLEILIFLLLGALVYSNSAVNPILYA 354

Human   306 LISKKFQARF 315
            .:|:.|:..|
  Fly   355 FLSENFRKSF 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CMKLR2	NP_001091669.1	7tmA_GPR1	39..315	CDD:320247	83/298 (28%)
		TM helix 1	41..65	CDD:320247	8/24 (33%)
		TM helix 2	73..94	CDD:320247	9/20 (45%)
		TM helix 3	111..133	CDD:320247	6/21 (29%)
		TM helix 4	156..172	CDD:320247	2/15 (13%)
		TM helix 5	204..227	CDD:320247	4/22 (18%)
		TM helix 6	245..267	CDD:320247	5/21 (24%)
		TM helix 7	283..308	CDD:320247	10/27 (37%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	81/290 (28%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	75/271 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010