DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slco1a1 and Oatp58Dc

DIOPT Version :9

Sequence 1:	NP_038825.1	Gene:	Slco1a1 / 28248	MGIID:	1351891	Length:	670	Species:	Mus musculus
Sequence 2:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	199/738 - (26%)
Similarity:	323/738 - (43%)	Gaps:	150/738 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 EGRFFSKMK-----VFLMSLT-CAYLAKSLSGVYMNSMLTQIERQFGIPTSVVGFITGSFEIGNL 70
            :|.|:.:..     |.|..:. |.:   |::..|.|..:|.||::|.||:...|.|:...:|...
  Fly   100 KGTFYQRFANQTAYVLLYGIVGCIF---SMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQT 161

Mouse    71 LLIVFVSYFGRKLHRPIIIGVGCVVMGLGCFLMASPHFLMGRYKYETTIS------PTSNLSSNS 129
            |:...::|:..|.|||..||.|.:.:...|.|..:||||.|..:....::      |..|.:..:
  Fly   162 LVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEA 226

Mouse   130 FLCIENRTQTL-KPTQDPTEC-VKEIKSLMWIYVLIGNTMRGIGETPIMPLGISYIEDFAKSENS 192
            .  .|.|::|| :......|| |.|......:.:.:...:.|||.:....||:||::|..|...:
  Fly   227 I--EEQRSKTLCRLNGGGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKT 289

Mouse   193 PLYIGILEMGKIVGPIIGLLLGSFFARVYV--DIGSVNTDDLTITPTDTRWVGAWWIGFLVCAGV 255
            |..:.:....:::||.||..|.||..|:|:  .:..|      |...|.||:||||:|:||..|:
  Fly   290 PALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPV------INNKDPRWLGAWWLGWLVMGGL 348

Mouse   256 NILTSIPFFFFPKTLPKKELQDNVDVTKYEKVEKHRERAKKENLGIT------------------ 302
            ...:.:....|||.||:        .....|||::|.| :||.|.:.
  Fly   349 LSFSGVFLSMFPKELPR--------AVARRKVEENRRR-EKERLSVKSTEKERLTAELDQKTTAE 404

Mouse   303 -----KDFLPFMKSLCCNPIYMLFSLTSVLQINGFASTFTFLPKYLEQQYGKSTSEAVFLIGVYS 362
                 :|.|...:.|..|..||..:|:|:..:.|:...:.|.|||:|.||.:|.:.:..:.|..:
  Fly   405 AKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVA 469

Mouse   363 LPPVCLGYLISGFIMKKFKITVKKAAYIA-----FGL----SLSEYFIFLC-----NYLLTCDNF 413
            |....:|.|:||||:.::|   .:|.|:|     .|.    .:..|....|     :.::...:.
  Fly   470 LAFSAVGVLLSGFIISRYK---PRARYMAAWNVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDS 531

Mouse   414 PVAGLTTSYKGVQHPLYGEKNVLADCNTRCSCLTDTWDPVCGDNGLAYMSACLAGCEK-SVGTGT 477
            .:||.||:                 ||:.|||....:.||||:|.:.|:|||.|||:| .|.:..
  Fly   532 SLAGNTTT-----------------CNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEG 579

Mouse   478 NMVFQNCSCIGS--SGNSS---------------------------------AVLGLCKKGPECD 507
            ..:|.:||||.|  :|||:                                 |:.|.|.  ..|.
  Fly   580 KKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACP--VNCW 642

Mouse   508 NKLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAGIPAPVYFGALID 572
            .:...||.......|:.:......::|.:|||..::|:..:|.......:||.||:|::||.:.|
  Fly   643 TQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFD 707

Mouse   573 RTCLHWGTLKCGQPGACRMYDINRFRHIYLGLPAAVRGS-SFLPAVFILI----LMRKFHFPGD- 631
            |.||.||. .|...|.|.:||           |.::|.: :|..||||.|    .:..:::..|
  Fly   708 RVCLVWGK-TCTNKGNCWLYD-----------PLSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDL 760

Mouse   632 -IHSPDTELAEMKLTEKESECTD 653
             |...|.:..|||:.:.|.|..:
  Fly   761 KIFDEDVKEVEMKIVQHEEEANN 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slco1a1	NP_038825.1	oat	1..625	CDD:273279	191/706 (27%)
		MFS	23..>396	CDD:119392	115/415 (28%)
		KAZAL_SLC21	436..488	CDD:238650	23/52 (44%)
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	182/672 (27%)
		MFS	114..>518	CDD:119392	117/426 (27%)
		KAZAL_SLC21	537..590	CDD:238650	25/69 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820