Protein Alignment GPM6B and M6

DIOPT Version :10

• Sequence 1: NP_001001995.1
• Gene: GPM6B / 2824
• HGNCID: 4461
• Length: 328
• Species: Homo sapiens
• Sequence 2: NP_001262166.1
• Gene: M6 / 40383
• FlyBaseID: FBgn0037092
• Length: 368
• Species: Drosophila melanogaster
• Alignment Length: 350
• Identity: 86/350 - (24%)
• Similarity: 145/350 - (41%)
• Gaps: 98/350 - (28%)

Human     3 PAMETAAEENTEQS-----------------QERKVNS-RAEMEIGRYHWMYPGSKNHQYHPVPT 49
            |..|...|.|.|..                 |.|:.|| |::..:.||
  Fly    68 PREEILLETNFEDDGGVLTRAYNGNPYNPTIQNRRRNSYRSDHSLDRY----------------- 115

Human    50 LGDRASPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNA 114
                   ....|..|||..|:..:|||:|:||::|..||.:||...:...:.||.:::|.|
  Fly   116 -------TERGGEGECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVDQVF---- 169

Human   115 SDHALL--SEVIQLMQYVI-YGIASFFFLYGIILLAEGFYTTSAVK-ELHGEFKTTACGRCISGM 175
              |..|  .|.:|::..:| .|:|:.    |.::|..||..|.|.: :::..:::...||....:
  Fly   170 --HLRLIWIEAVQMIFVIIGAGMAAL----GFMILFVGFLATGATRYKVYRAWRSRVGGRISCAV 228

Human   176 FVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVE--QICVDIRQYGIIPWN 238
            .:.:||:|...|..:..|..|..|::...|:.|           |.||  |.|:|:.|:..:
  Fly   229 LMGITYLLNFVWSLILCFLVVVTFIYTMFWNMC-----------TSVEHSQSCIDLTQFHFM--- 279

Human   239 AFPGK----------------ICGSALENICNTNEFYMSYHLFIVACAGAGATVIALIHFLMILS 287
             ||..                .|...:||         :..:||:|.......:::|:|:||.||
  Fly   280 -FPPNTKLEDMKVCEKYEIKAFCKDGVEN---------AEVMFILATLSTLLVLLSLVHYLMCLS 334

Human   288 SNWAYLKDASKMQAYQDIKAKEEQE 312
            :|:|:::|..|.|..|:|:...|.|
  Fly   335 ANYAHIRDHEKFQELQEIQNLNELE 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPM6B	NP_001001995.1	Myelin_PLP	63..298	CDD:460144	67/256 (26%)
M6	NP_001262166.1	Myelin_PLP	122..345	CDD:460144	67/256 (26%)