Protein Alignment SLCO1B3 and Oatp58Dc

DIOPT Version :10

• Sequence 1: NP_062818.1
• Gene: SLCO1B3 / 28234
• HGNCID: 10961
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_611659.2
• Gene: Oatp58Dc / 37545
• FlyBaseID: FBgn0034716
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 771
• Identity: 214/771 - (27%)
• Similarity: 331/771 - (42%)
• Gaps: 170/771 - (22%)

Human     7 LNKTAESASSEKKKTRRCNGFKMFLA------ALSFSYIAKALGGIIMKI----------SITQI 55
            :||....:..||..|  | ||.:|..      |...:|:  .|.||:..|          :||.|
  Fly    79 INKLLAESPLEKNVT--C-GFWIFKGTFYQRFANQTAYV--LLYGIVGCIFSMTYAYFNGTITTI 138

Human    56 ERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMG- 119
            |:||.|.|...|:|....:|...||...::|:..|.|||:.||.|.|.:....|||:.|||..|
  Fly   139 EKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGP 203

Human   120 ---YYRYSKETHINPSENST-------SSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYV 174
               ....:.|....|.||:|       .|.:.|.:|.    .|...|:.|.:...:      :.:
  Fly   204 GEDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNG----GGAECEVGEGNFAPQ------LLL 258

Human   175 FMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGY 239
            |:...:.|||.:....||:||:||..|:..:...|.....:.|:||.||:||.|...::|:   .
  Fly   259 FVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYI---A 320

Human   240 VDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKIS---------LS 295
            ..:..: |..||.||:||||||:||.|.....|.:.....||...:....||:.         ||
  Fly   321 PQMHPV-INNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELPRAVARRKVEENRRREKERLS 384

Human   296 LHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSL----KSILTNPLYVIFLLLTLLQVSSFIGSF 356
               :|:.:....||.|   .:..|......||.:    :.::||..|:...|.::..:..:...:
  Fly   385 ---VKSTEKERLTAEL---DQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYW 443

Human   357 TYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFK---------------LSLVG 406
            .:..||:|.||.|||:.::.:.|.:.:...|.|:.|.||||.::|               |::.|
  Fly   444 IFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAG 508

Human   407 IAKFSFL------TSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNC 465
            |..::|:      :|:|          :.....|:||.|.|                 |||.|:|
  Fly   509 ILAYAFIGCPGNESSVI----------VNIHDSSLAGNTTT-----------------CNSACSC 546

Human   466 DESQWEPVCGNNGITYLSPCLAGCK----SSSGIKKHTVFYNCSCVEVTGLQN------------ 514
            |..::.||||.|.:||:|.|.||||    :|.|.|   :||:|||:......|
  Fly   547 DYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKK---IFYDCSCIPSDDAGNSTSQFKRLTSFD 608

Human   515 -------RNYSAHL------------GECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTV 560
                   :|.|.|.            |.||.:  |..:|..::|:........|:|..:..|::|
  Fly   609 LSNDEVSQNTSVHSQLEALANGQAMPGACPVN--CWTQFVAFLAVMCCLKFVGASGRASNFLVSV 671

Human   561 KIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVY 625
            :.|..:.|..||||...:...|..|.:||:||.:.|:.|:.|. .:|..:|.|.:|:.
  Fly   672 RCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWG-KTCTNKGNCWLYDP------- 728

Human   626 LGLSIALRFPALV-LYIVFIFAMKKKFQGKDTKASDN-----ERKVM---DEANLE 672
            |.:...|.|.|.| :.|..||.:...:..||.|..|.     |.|::   :|||.|
  Fly   729 LSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVKEVEMKIVQHEEEANNE 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B3	NP_062818.1	MFS	28..561	CDD:475125	168/628 (27%)
Oatp58Dc	NP_611659.2	OATP	113..731	CDD:460821	187/679 (28%)