Protein Alignment SLCO1B3 and Oatp58Db

DIOPT Version :10

• Sequence 1: NP_062818.1
• Gene: SLCO1B3 / 28234
• HGNCID: 10961
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_611658.3
• Gene: Oatp58Db / 37544
• FlyBaseID: FBgn0034715
• Length: 680
• Species: Drosophila melanogaster
• Alignment Length: 668
• Identity: 176/668 - (26%)
• Similarity: 319/668 - (47%)
• Gaps: 95/668 - (14%)

Human    26 GFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSK 90
            |......|::|:|...         :||.:|:||:|.:.::|||....:|..:....|:||:.|:
  Fly    59 GIASCFLAMAFTYFTG---------TITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASR 114

Human    91 LHRPKLIGIGCLLMGTGSILTSLPHFFMG----YYRYSKETHINPSENSTSSLSTCLINQTLSFN 151
            .|||:.:.:|.:::....:|...||.|.|    ..|.::|  ...||:..:||:....|.:|...
  Fly   115 GHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEE--YGMSESFGASLNITEKNDSLCHE 177

Human   152 GTSPEIVEKDCVKESGSHMWIYV-FMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAI 215
            ..|      :|::.:|.:..|.: |:...:.|||.:.....|:||:||.:....:...|...:.:
  Fly   178 KNS------NCLERAGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFL 236

Human   216 GMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLP 280
            .|:||.:||::.||..::|:|    ......||..|.||:||||:|:::......||::.....|
  Fly   237 RMLGPAMGFSMVSLCLRLYID----PFKKPLITTNDPRWMGAWWIGWILLTFILTISAVFVGMFP 297

Human   281 KNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQ----SLKSILTNPLYVIF 341
            |...:.:..|        ||.:.:.    ::...|::        ||    |||.:.:|.:||..
  Fly   298 KEMPRAKARR--------LKADGEE----DIPLAGRS--------FQDMLDSLKRLASNKVYVYN 342

Human   342 LLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVG 406
            :|.::|.:..::..:.:..||:|.||.||||.:....|...:...|.|:.:.|::|.|:|.|...
  Fly   343 MLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARA 407

Human   407 IAKFSFLTSMISFLFQLLYFPLIC-ESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQW 470
            :|.::|:...::....|.|..:.| ||.....|::...|::            |::.|.|:...:
  Fly   408 MAAWNFVVDYLTVAGMLCYVLVGCDESDRANSLSIVPTGDS------------CSASCVCEYVYY 460

Human   471 EPVCGNNGITYLSPCLAGC--KSSSGIKKHTVFYNCSCV----------EVTGLQNRNYSAHLGE 523
            .|||....||::|.|.|||  |:.:.:.| |::..|.|:          .||.|.:::..|..|.
  Fly   461 APVCSPENITFISACHAGCTDKAINELGK-TIYTGCRCMGNVSSIISLSNVTSLASQSQIAMDGA 524

Human   524 CPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAP 588
            ||.|  |.::|.|::|:........|||.::.:||.::.|..:.|..::||.|||...|..|.:|
  Fly   525 CPVD--CNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSP 587

Human   589 IYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFP-----ALVLYIVFIFAMK 648
            |.||.::|..|:.|. .:|.::|.|.||::.           :||:.     |.::::...:.:.
  Fly   588 IVFGWMLDSYCLVWG-KTCSSKGNCWIYDTK-----------SLRYTMNLVCASLIFLGSFWNIG 640

Human   649 KKFQGKDTKASDNERKVM 666
            ..:..||.|..|.:.|.:
  Fly   641 VWYHAKDMKVFDEDEKTV 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B3	NP_062818.1	MFS	28..561	CDD:475125	146/554 (26%)
Oatp58Db	NP_611658.3	OATP	53..619	CDD:460821	168/627 (27%)