Protein Alignment SLCO1B3 and Oatp58Da

DIOPT Version :10

• Sequence 1: NP_062818.1
• Gene: SLCO1B3 / 28234
• HGNCID: 10961
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 708
• Identity: 190/708 - (26%)
• Similarity: 326/708 - (46%)
• Gaps: 102/708 - (14%)

Human     8 NKTAESASSEKK------KTRRCNGFKMF-------LAALSFSYIAKALGGIIMKI-------SI 52
            :|..|||...:.      |...| ||.:|       .|......|...|.|.:|.:       :|
  Fly    27 DKERESAPENETEGEDGGKDTYC-GFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTFAYFNGTI 90

Human    53 TQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFF 117
            |.:|:|:.|.:.::|:|....:|..:|....:.|:....|||:.:|||.|.:....:|||..||.
  Fly    91 TTLEKRYKIPTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFL 155

Human   118 MGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGS------HMW---IY 173
            .|    :.|..:..:.....      :|:||    |:.|..:|.|...:|.      .:|   ::
  Fly   156 YG----AGEDALQLTREFGQ------VNETL----TNQERDKKLCQPTAGGCVQEEVGLWVPQVF 206

Human   174 VFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIG 238
            :|...::.|:|:.....|||:|:||...:..:...|.....:.|:||.||::|.::..::|::..
  Fly   207 LFAAQLISGVGQALFYTLGIAYMDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPT 271

Human   239 YVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTND 303
            ...|    |..:|.||:||||||:||....:::|:|..|..||.....:| |::.|.      .|
  Fly   272 LEPL----IGQEDPRWLGAWWLGWLVLAAITLVSAILLFMFPKQLPSARK-RRLQLK------QD 325

Human   304 DRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYG 368
            :|.|:..|..      :::....:::|.:..|.:||...:.::|....::..:.:..||:|.||.
  Fly   326 ERKQSLPLNE------RSLADMMKTVKKLSKNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYR 384

Human   369 QSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESK 433
            |||:.|....|.:.:...|.|:.:.|::|.|:|.|...:|.::.:...::....|.|..:.||..
  Fly   385 QSAAMATMATGTVALGFSAAGILISGYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGS 449

Human   434 SVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGC----KSSSG 494
            .......|....||           |::.|:||...:.|||..:.||::|.|.|||    |.:.|
  Fly   450 DRLNTLTTLSAGNS-----------CSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDALG 503

Human   495 IKKHTVFYNCSCVEVTGLQNRNYS--AHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFIL 557
               .|::..|.|:..:.|.:...|  |..|.||.|  |..:|.|::.:.....|..|:..:|.:|
  Fly   504 ---RTIYTGCECLGSSSLNSEPESQFAVDGTCPVD--CFNEFLIFLGVMCFLKLVGASSKSTNLL 563

Human   558 LTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIY------ 616
            |.::.:.|:.|..|:|..||....||.|.:||:||.|||..|:.|. .:|..:|.|.:|
  Fly   564 LALRCMPPDEKTFALGLGSMAASLLGFIPSPIFFGWLIDNYCLVWG-KTCSNKGNCWLYDTKSMR 627

Human   617 -----NSVFFGRVYLG--LSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMD 667
                 ::.||  ::||  |:||:.:.|..|.   ||..::.......|..:.|.|.:|
  Fly   628 YALNLSAAFF--IFLGGFLNIAVWYHAKNLK---IFDEEESSPKDSLKNKEVEMKTID 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B3	NP_062818.1	MFS	28..561	CDD:475125	145/561 (26%)
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	165/606 (27%)