Protein Alignment SLCO1B3 and Oatp33Eb

DIOPT Version :10

• Sequence 1: NP_062818.1
• Gene: SLCO1B3 / 28234
• HGNCID: 10961
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_609570.1
• Gene: Oatp33Eb / 34662
• FlyBaseID: FBgn0032435
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 668
• Identity: 147/668 - (22%)
• Similarity: 273/668 - (40%)
• Gaps: 139/668 - (20%)

Human    46 IIMKISIT---QIERRFDISSSLAGLIDGSFEIG-NLLVI------------VFV---SYFGSKL 91
            :::.||.|   ..|..|.:|:..|     ||:.| |.|::            ||.   :|:....
  Fly    51 LVLAISGTLQGACESYFRVSAKQA-----SFQFGWNPLIVDWLLVASGLFQAVFALAFAYWADVY 110

Human    92 HRPK-LIG------IGCLLMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLIN---- 145
            |..| |:|      :.|::    :::.|:.:|..|          |.::::....:.|..:
  Fly   111 HPIKWLVGTLMLQAVTCVV----AVIPSIMNFADG----------NQAKDALLDANMCATSLAQF 161

Human   146 QTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLG 210
            |.|:....           :|.|.....:|:..:..|:|......||:|||||.:....|...:|
  Fly   162 QRLTLTEA-----------QSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIG 215

Human   211 SLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIP 275
            :    .:...|.|...|| |..:.|.:.:|                .||||:::...|..:.::.
  Fly   216 A----ALAARVFGQQAGS-FLVLGVGLTHV----------------GWWLGWVILAPFIFVGAVL 259

Human   276 FFFLPKNPNKP---QKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNV--TGFFQSLKSILTN 335
            ....||...|.   |..::|.             :.:::...|...:..:  :.|:.|||.:..|
  Fly   260 LGLFPKRLPKTVIHQAAQRII-------------EQSSMRRFGSQFSTYMDDSDFWPSLKRLFNN 311

Human   336 PLYVIFLLLTLLQVSSFIGSF----------TYVFKYMEQQYGQSASHANFLLGIITIPTVATGM 390
            .| ::|.||:::.|.|.:.::          .:...|.||....:...:.|:...:..|.:|.||
  Fly   312 RL-LMFNLLSIMCVQSAVVNYGLQEESYLQSRFFLPYNEQDGLAAEWRSAFVSYFLKPPVMALGM 375

Human   391 FLGGFIIKKFKLSLVGIAKFSFLTS--MISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVD 453
            .:.|.:|.|.|||...|...:...|  :::....|::  :.|:..::||:    :|..
  Fly   376 LISGLVISKAKLSARKITGINIALSIHLVAIFIGLIF--VQCDVGAIAGV----EGGK------- 427

Human   454 VPLSYCNSECNCDESQWEPVC-GNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNY 517
            :...||:|:|.|..:.:.||| .|:.:||.|||.|||...:.|....:|..|||   :|.|:.|.
  Fly   428 LKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSC---SGDQSLNS 489

Human   518 SAHL----GECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMV 578
            :..:    |.|..|| |.....|:..:.:..:.....|.....|:|::.|.|:.|:||:.|:.|:
  Fly   490 TGQMRATAGACSSDN-CQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSLALAFELMI 553

Human   579 IRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVF 643
            :.....:...:.:..:...||:.|:.|    ...|.:..:...|.: |.:..|....|.||:.:.
  Fly   554 VGLFAYVPVHLSYDIVTRTTCVYWAPN----YERCLLRETPKHGNI-LDILTASLILASVLFDIL 613

Human   644 IFAMKKKFQGKDTKASDN 661
            ::...|.....:.|.:||
  Fly   614 VYIFAKGLNLYNCKVTDN 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B3	NP_062818.1	MFS	28..561	CDD:475125	125/566 (22%)
Oatp33Eb	NP_609570.1	MFS_SLCO_OATP	46..536	CDD:340894	125/566 (22%)
		PHA03247	<635..813	CDD:223021