Protein Alignment SLCO1B3 and Oatp33Ea

DIOPT Version :10

• Sequence 1: NP_062818.1
• Gene: SLCO1B3 / 28234
• HGNCID: 10961
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Alignment Length: 725
• Identity: 188/725 - (25%)
• Similarity: 314/725 - (43%)
• Gaps: 122/725 - (16%)

Human    28 KMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLH 92
            |||:.........:|:..:...:::|.:|:||.|.|...|:|....||..:::.:.:||.|.:.:
  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99

Human    93 RPKLIGIGCLLMGTGSILTSLPHFFMG----YYRYSKE---------THINPSENSTSSLST--- 141
            ||:.|..|.:..|....:..||||..|    ..:::||         |..:.|..:.||:.|
  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERL 164

Human   142 CLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSS 206
            |.:::|           |.||.........:.:|:...:.|:|.|....||.:|:||..|:.::.
  Fly   165 CGVDKT-----------EDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTP 218

Human   207 LYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSG-LFSI 270
            |.|....|:.|||||:||..|.:....::|    ...|..|..||.||:||||||:::.| |..:
  Fly   219 LMLAVAMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCL 279

Human   271 ISSIPFFF---LPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQ-GKNVTKNVTG------- 324
            .|.:...|   ||| .|..:....:.|:|...|....|.:..:|::: ..|...:..|
  Fly   280 FSGLIGLFPKQLPK-VNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANA 343

Human   325 -------FFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIIT 382
                   |.::|..:|.|.|.:..:|..:..:....|..|::.||||.|:.:.|..|..::|.|:
  Fly   344 DLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPIS 408

Human   383 IPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNS 447
            |..:..|:...|.::.|.|.|:..:..::.:...||.|.|:.|..|.|.:.    .::|..|..:
  Fly   409 IMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNT----FSMTQAGQLN 469

Human   448 VASHVDVPLSYCNSECNCDESQWEPVCGN-NGITYLSPCLAGCKSSSGIKKHTVFYNCSCV---- 507
            :.|:       ||..|:|:...:.|||.. ...|:.|.|.|||:..:...|  ::.:||||
  Fly   470 LTSN-------CNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSK--LYEDCSCVVNDP 525

Human   508 -----------------------------EVTGL----QNRNYSAHL---------------GEC 524
                                         .::|:    .|.::...|               |.|
  Fly   526 APKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGIC 590

Human   525 PRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPI 589
            .::  |...|:.:....:|.|.|.::|....:|:..:.|..|.|:.|.|...|:|..|..|..||
  Fly   591 TKN--CNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPI 653

Human   590 YFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVL-YIVFIFAMKKKFQG 653
            .||.|||.||:.| |.:|...|.|::|:...|......||..|.|..|:. |:|:.:.......|
  Fly   654 IFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDIYG 717

Human   654 KDTKASDNER 663
             |.:|.:.||
  Fly   718 -DKEAKEEER 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B3	NP_062818.1	MFS	28..561	CDD:475125	151/620 (24%)
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	174/679 (26%)