Protein Alignment SLCO1B3 and Oatp30B

DIOPT Version :10

• Sequence 1: NP_062818.1
• Gene: SLCO1B3 / 28234
• HGNCID: 10961
• Length: 702
• Species: Homo sapiens
• Sequence 2: NP_609293.2
• Gene: Oatp30B / 34268
• FlyBaseID: FBgn0032123
• Length: 1197
• Species: Drosophila melanogaster
• Alignment Length: 770
• Identity: 241/770 - (31%)
• Similarity: 382/770 - (49%)
• Gaps: 129/770 - (16%)

Human    28 KMFLAALS-FSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKL 91
            |:|:..|| ...:.:||....:...||.||:||:|.||.:|||..|:||||::.::||||.||:.
  Fly   170 KIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRR 234

Human    92 HRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHINP--------SENSTSS---------- 138
            |.|..||||.::||.||::..:|||         ....||        |:|...|
  Fly   235 HIPVWIGIGAVIMGIGSLVFMVPHF---------TGEPNPGIAIVNKTSDNICKSALVRDQDMDL 290

Human   139 --LSTCLINQTLSFNGTSPEIVEKD-CV--KESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDD 198
              ||:.|.||.|     :|..:.:| |:  |.|.:...:...:..:|.|.|.:|:..||.:|:||
  Fly   291 GRLSSGLSNQPL-----APHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYVDD 350

Human   199 FAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFL 263
            ..:...||:|:|.:.::|..|||:||.||:.....::|  .:..:||.|||.|.||||.||.|||
  Fly   351 HVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWVGMWWGGFL 413

Human   264 VSGLFSIISSIPFFFLPKNPNKPQKE-RKISLSLHVLKTN------------------------D 303
            :.|:..::.::|||..||...:.:|: ||.|:...||..|                        :
  Fly   414 LCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKE 478

Human   304 DRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLL---LTLLQVSSFIGSFTYVFKYMEQ 365
            |::|.....:.|..  |::....||:..::.||:|::..|   :.|:.||.|:   .::.||:|.
  Fly   479 DQSQAPPKVDTGYG--KDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFV---VFLPKYLET 538

Human   366 QYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLIC 430
            |:....|.||...|.|.:|....|:||||.|:|:|:|...|..:|..:|::|......:.|.|.|
  Fly   539 QFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGC 603

Human   431 ESKSVAGLTLTYDGNNSVASHVDVPL-----SYCNSECNCDESQWEPVCGNNGITYLSPCLAGCK 490
            ::..:||.|:.|..:|...|.::.|.     :.||..|.|..|:.||||||||:||.|||.|||.
  Fly   604 DNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCT 668

Human   491 SSSGIKKHTVFYNCSCVEVT----------GLQ------NRNYS-------AHLGECPRDNTCTR 532
            :.|. ..:|.:.||:||...          |.|      |.|::       |..|.|.   |..|
  Fly   669 AFSS-TSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCA---TPCR 729

Human   533 KFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDK 597
            ..:.::.:....:...|:.....:::.::.|..|.::.|:|.|.::.|..|.|.|||.||.|||.
  Fly   730 TIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDS 794

Human   598 TCMKWSTNSCGAQGA-CRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQ---GKDTKA 658
            ||:.|. :|||.:|. |.||:...|...|:||..:::..|||:::|..:.::::.|   .|...|
  Fly   795 TCILWK-SSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRRRKQLEKMKPLNA 858

Human   659 SD-------------NERKVMDEANLEFL-NNGEHFVPS-----AGTDSKTCNLD 694
            ||             .|:....|.:..|: ..||..:|:     :..||:|.::|
  Fly   859 SDPIIGSIISLDKLFEEKLSGAEPSTAFVGGGGELIIPTDILRHSRNDSRTMHMD 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1B3	NP_062818.1	MFS	28..561	CDD:475125	192/612 (31%)
Oatp30B	NP_609293.2	MFS_SLCO5_OATP5	170..758	CDD:340962	192/612 (31%)
		UhpC	<730..795	CDD:441872	17/64 (27%)