DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLCO3A1 and Oatp58Dc

DIOPT Version :9

Sequence 1:	NP_037404.2	Gene:	SLCO3A1 / 28232	HGNCID:	10952	Length:	710	Species:	Homo sapiens
Sequence 2:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	196/763 - (25%)
Similarity:	320/763 - (41%)	Gaps:	146/763 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    12 GGRSGELQGDEAQRNKKKKKK-----------------------VSCFSNIKIF-------LVSE 46
            |.:.||....:..::||||:|                       |:|  ...||       ..::
  Fly    48 GNQDGEETTPKTGKSKKKKQKSEQDRLMTAEINKLLAESPLEKNVTC--GFWIFKGTFYQRFANQ 110

Human    47 CALMLAQGTVG-------AYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGH 104
            .|.:|..|.||       ||....:||:|:||.:.|.:.|:|:...:|....:...::|:..:||
  Fly   111 TAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGH 175

Human   105 RPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGE------IRWGA--------------EGRDV 149
            |||.||.|.:.:....:|:..|.||     |..||      ..:|.              ..:.:
  Fly   176 RPRWIGFGLLTIVFFCILTTAPHFL-----YGPGEDALALTSEFGGMPDENATMEAIEEQRSKTL 235

Human   150 CAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLY 214
            |..||.|.:        |..........|||..||.:.|||.:....|||||:||:.::..:...
  Fly   236 CRLNGGGAE--------CEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPAL 292

Human   215 IGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSS 279
            :.:.:.:.:.|||.|:.|.|||.::|:    ....:..|...||||:||||.|:|:.|.||.||.
  Fly   293 LSLSYFLRMLGPAIGYALASFCLRLYI----APQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSG 353

Human   280 LLMFGFPQSLP-------PHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRV 337
            :.:..||:.||       .......|.|:..:...|.||       |...|:..::|......:.
  Fly   354 VFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKER-------LTAELDQKTTAEAKASFQD 411

Human   338 IPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLG 402
            :.|..:.|::|..:.|..|::...:.....:..|..||:|.|:..:.::::.:.|..|:..:.:|
  Fly   412 MLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVG 476

Human   403 IFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDP 467
            :.|.|.::.:....|.......::|..::.|..:::.|:|| .|..:.|.|...:|:..|:.
  Fly   477 VLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGC-PGNESSVIVNIHDSSLAGNT--- 537

Human   468 YSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNS--TNLTG------CACLTTVPAENAT--- 521
             :.||:.|.|....::||||.:.:||:|||.|||..  .|..|      |:|:.:..|.|:|
  Fly   538 -TTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQF 601

Human   522 ------------------------------VVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTP 556
                                          .:||.|| ..|...|:.||.|||....:||..:..
  Fly   602 KRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACP-VNCWTQFVAFLAVMCCLKFVGASGRAS 665

Human   557 SVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVV 621
            :.::.:|.|..:.|:.|:|....|..:|.|||.|:.||...|..||.|...|..:|.|.|||.:.
  Fly   666 NFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTNKGNCWLYDPLS 730

Human   622 YRYLYVSIAIALKSFAFILYTTTWQCLR---------KNYKRYIKNHE 660
            .||.....|....:...|.....|...:         |..:..|..||
  Fly   731 MRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVKEVEMKIVQHE 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLCO3A1	NP_037404.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		3/12 (25%)
		OATP	41..619	CDD:281175	176/659 (27%)
		MFS	47..>286	CDD:119392	78/265 (29%)
		KAZAL_SLC21	467..511	CDD:238650	19/51 (37%)
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	175/648 (27%)
		MFS	114..>518	CDD:119392	110/428 (26%)
		KAZAL_SLC21	537..590	CDD:238650	20/56 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750