DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLCO3A1 and Oatp58Db

DIOPT Version :9

Sequence 1:	NP_037404.2	Gene:	SLCO3A1 / 28232	HGNCID:	10952	Length:	710	Species:	Homo sapiens
Sequence 2:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	176/637 - (27%)
Similarity:	286/637 - (44%)	Gaps:	98/637 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    41 IFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHR 105
            ::.::.|.|.:|    ..|....:||:|:|||:.:...|:|....:|..:....|:||:.:||||
  Fly    57 VYGIASCFLAMA----FTYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHR 117

Human   106 PRLIGCGGIVMALGALLSALPEF----------LTHQYKYEAGEIRWGA-----EGRD-VCAANG 154
            ||.:..|.|::|:..||...|..          ||.:|.....   :||     |..| :|....
  Fly   118 PRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEEYGMSES---FGASLNITEKNDSLCHEKN 179

Human   155 SGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILF 219
            |.          |..|.......:|...||.:.|||.:.....|:||:||:.....:...:....
  Fly   180 SN----------CLERAGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSS 234

Human   220 TMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFG 284
            .:.:.|||.||.:.|.|.::|:|..    ....||.:||||:||||.|::|...:|..|::.:..
  Fly   235 FLRMLGPAMGFSMVSLCLRLYIDPF----KKPLITTNDPRWMGAWWIGWILLTFILTISAVFVGM 295

Human   285 FPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNP 349
            ||:.:|                |...|...::|....||...|.......|       |.|.||.
  Fly   296 FPKEMP----------------RAKARRLKADGEEDIPLAGRSFQDMLDSL-------KRLASNK 337

Human   350 VFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLS 414
            |:...:||:.:.:.....:..|..||:|.|:..:.|::....|..|:..:..||.:.|.::.|..
  Fly   338 VYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYK 402

Human   415 LSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAG--VTVPYGNSTAPGSALDPYSPCNNNCEC 477
            .||........:|:.::.|..:.::.:|||....|.  ..||.|:|            |:.:|.|
  Fly   403 PSARAMAAWNFVVDYLTVAGMLCYVLVGCDESDRANSLSIVPTGDS------------CSASCVC 455

Human   478 QTDSFTPVCGADGITYLSACFAGC--------NSTNLTGCACL------------TTVPAENATV 522
            :...:.|||..:.||::|||.|||        ..|..|||.|:            |::.:::...
  Fly   456 EYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRCMGNVSSIISLSNVTSLASQSQIA 520

Human   523 VPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFI 587
            :.|.|| ..|.:.||.||.|||....:||..::.::::.:|.|..:.|:::||...::..:|.||
  Fly   521 MDGACP-VDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFI 584

Human   588 PPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRY---LYVSIAIALKSF 636
            |.|::||..:||.||.|...|..:|.|.:||....||   |..:..|.|.||
  Fly   585 PSPIVFGWMLDSYCLVWGKTCSSKGNCWIYDTKSLRYTMNLVCASLIFLGSF 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLCO3A1	NP_037404.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		OATP	41..619	CDD:281175	168/615 (27%)
		MFS	47..>286	CDD:119392	73/254 (29%)
		KAZAL_SLC21	467..511	CDD:238650	18/51 (35%)
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	169/618 (27%)
		MFS	55..>410	CDD:119392	104/396 (26%)
		KAZAL_SLC21	447..499	CDD:238650	20/63 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850