Protein Alignment SLCO4A1 and Oatp74D

DIOPT Version :9

• Sequence 1: XP_011527094.1
• Gene: SLCO4A1 / 28231
• HGNCID: 10953
• Length: 768
• Species: Homo sapiens
• Sequence 2: NP_001163460.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 721
• Identity: 194/721 - (26%)
• Similarity: 323/721 - (44%)
• Gaps: 105/721 - (14%)

Human    15 SPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEVRYVS 79
            |.|:...||  |:...:.|....||:.|     ...|..:|:.......::.:|..        |
  Fly   101 SNNNGTGNG--HSLSEKYAHEQAPLTGG-----YKLPPRSSESEESDFDSDLNGGS--------S 150

Human    80 AGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGL 144
            |..|.:||.:...|...:...:....:.....|..||||.:..|: :|||::|:.:.:.|..:|:
  Fly   151 AESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFV-SVITTIEKLFQIKSKTTGI 214

Human   145 IASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCP 209
            :.|:.::........::||.|.||:|||:..|::|....:...|||||..|...:.....::...
  Fly   215 LLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQ 279

Human   210 ANP-------------------------------GAVCAD-------STSGLSRYQLVFMLGQFL 236
            .:|                               |:.|.:       |.|.::...|....|..|
  Fly   280 VSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLL 344

Human   237 -HGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELT 300
             .|:|.|.:.|||:.|:|:||.|..||:|:|:.....|||||:|::.|......|..........
  Fly   345 SSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFDA 409

Human   301 TESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQR--------YAVMRAAEMHQLKDSSR 357
            |: |.|:||||:|.:..|:.....::.:..:|:||.|.|:        .|.:...|..:||
  Fly   410 TD-PRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEPEEKPKLK---- 469

Human   358 GEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEA- 421
                  ||.||:|....:..|:.:..:.:...|.       |.|:.||.||:||:||.|:..:|
  Fly   470 ------DFPKTVRRQLSNDILMFRTASCVFHLLP-------IAGLYTFLPKYLETQFRLATYDAN 521

Human   422 --ATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLG-ILVFSLHCPSVPMAG 483
              |...|.||:   |.|..:.|.|:.|.:.....|..:..|..:|...| |::..:.|.....||
  Fly   522 MIAAFCGILVM---GIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAG 583

Human   484 VTASYGGSLLPEGHLNLTAP-CNAA--CSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQ 545
            ...|.|.|  |.    |..| |:||  |:|..|:::|:| :||.||.|.|||||.:::....|.:
  Fly   584 YKPSDGNS--PA----LIEPTCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSSSSLRPSDNR 641

Human   546 KVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQ 610
            .:|.||:|||.     ...|..|.|.:.|:.....::...:.:|....|.:.::...:||.....
  Fly   642 TLYSDCACIPD-----APEAVNGYCDNNCKNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKD 701

Human   611 RSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYIL--IMGLL 673
            ::.|:|:....:.:.|.:|.||.:|.|:|.|||:|:..||:.|:|.:|......:|.|  ..|::
  Fly   702 KAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQYFLGITAGIM 766

Human   674 YKAPLL 679
            :.|.|:
  Fly   767 FLAFLM 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO4A1	XP_011527094.1	OATP	106..663	CDD:281175	171/610 (28%)
		MFS	106..>489	CDD:119392	115/433 (27%)
		KAZAL_SLC21	500..555	CDD:238650	25/57 (44%)
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	171/612 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810