Protein Alignment SLCO4A1 and Oatp58Dc

DIOPT Version :9

• Sequence 1: XP_011527094.1
• Gene: SLCO4A1 / 28231
• HGNCID: 10953
• Length: 768
• Species: Homo sapiens
• Sequence 2: NP_001097409.1
• Gene: Oatp58Dc / 37545
• FlyBaseID: FBgn0034716
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 693
• Identity: 190/693 - (27%)
• Similarity: 311/693 - (44%)
• Gaps: 113/693 - (16%)

Human    82 QSVACGWWAFAPPCLQ--VLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGL 144
            ::|.||:|.|.....|  ...|...:|:.:....|  .||. .:.|..||::|:|:.:.|..:|:
  Fly    90 KNVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIF--SMTY-AYFNGTITTIEKRFKIPSKNTGI 151

Human   145 IASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYE----------- 198
            |:...||:..|....::|:.|.||:|||:|:|:|.:....::...|||..|..|
  Fly   152 ISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGG 216

Human   199 ----------VELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTYLD 253
                      :|.......|..|.|....:...|....||:..:.||:.|:|.:..|||||:|:|
  Fly   217 MPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMD 281

Human   254 ENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLGSG 318
            :|.|.|.:|..:::.|...:||||.||.:....|.:|........:..:.|.|:||||:|:|..|
  Fly   282 DNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKDPRWLGAWWLGWLVMG 346

Human   319 AAAFFTAVPILGYPRQLPGS--------------QRYAVMR------AAEMHQLKDSSRGEASNP 363
            ....|:.|.:..:|::||.:              :|.:|..      .||:.| |.::..:||..
  Fly   347 GLLSFSGVFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLTAELDQ-KTTAEAKASFQ 410

Human   364 DFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYL 428
            |..||.|       .|:.|.|::...|:........|....|:||::|.|:..||:.::.:.|.:
  Fly   411 DMLKTFR-------RLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTV 468

Human   429 VVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFS-LHCPSVPMAGVTASYGGSL 492
            .:.....|..|.||.:::.:.|...:..:.:....:::.|||.:: :.||....:.:...:..||
  Fly   469 ALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDSSL 533

Human   493 LPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQ- 556
            ...     |..||:||||....||||||.:.:.|.|.|||||.... .|.:|:|::.||||||.
  Fly   534 AGN-----TTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLL-VNSEGKKIFYDCSCIPSD 592

Human   557 ---NLSSGF----------------------------GHATAGKCTSTCQRKPLLLVFIFVVIFF 590
               |.:|.|                            |.|..|.|...|..:  .:.|:.|:...
  Fly   593 DAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNCWTQ--FVAFLAVMCCL 655

Human   591 TFLSS---IPALTATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQ 652
            .|:.:   ......::|||.:..::.|:|....:..:|..||.||.||||.|:.||:|...|..:
  Fly   656 KFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTNK 720

Human   653 GSCLVYQNSAMSRY--------------ILIMGLLYKAPLLRI 681
            |:|.:|...:| ||              |..:|:.|.|..|:|
  Fly   721 GNCWLYDPLSM-RYTLNFTAAVFIAIGAIFDLGVWYYAKDLKI 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO4A1	XP_011527094.1	OATP	106..663	CDD:281175	174/633 (27%)
		MFS	106..>489	CDD:119392	110/424 (26%)
		KAZAL_SLC21	500..555	CDD:238650	27/54 (50%)
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	174/637 (27%)
		MFS	114..>518	CDD:119392	108/414 (26%)
		KAZAL_SLC21	537..590	CDD:238650	27/53 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810