Protein Alignment SLCO4A1 and Oatp58Da

DIOPT Version :10

• Sequence 1: XP_011527094.1
• Gene: SLCO4A1 / 28231
• HGNCID: 10953
• Length: 768
• Species: Homo sapiens
• Sequence 2: NP_611657.2
• Gene: Oatp58Da / 37543
• FlyBaseID: FBgn0050277
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 627
• Identity: 178/627 - (28%)
• Similarity: 282/627 - (44%)
• Gaps: 63/627 - (10%)

Human    73 HEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDL 137
            :|......|:...||:|.|..|.:|...|....:.....|..:..||. .:.|..||:||:||.:
  Fly    36 NETEGEDGGKDTYCGFWIFKGPSMQRFATEHMYVILYGLAGCVMTMTF-AYFNGTITTLEKRYKI 99

Human   138 HSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVEL- 201
            .:..||:|:...||:..|....:.|:.|..|:|||:|.|:|.:....|:.:..||..|..|..|
  Fly   100 PTKVSGIISVGNDISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQ 164

Human   202 ---------------DAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTY 251
                           :...:.|....|. |.....||...|:.....|.:.|||....||||:.|
  Fly   165 LTREFGQVNETLTNQERDKKLCQPTAGG-CVQEEVGLWVPQVFLFAAQLISGVGQALFYTLGIAY 228

Human   252 LDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLG 316
            :|:|...:.:|..:::.....:||||.||.:....|.:|.|......:..|.|.|:||||:|:|.
  Fly   229 MDDNTSKAKTPAMLSMSTFLRMLGPAIGYSLAAVCLRLYIEPTLEPLIGQEDPRWLGAWWLGWLV 293

Human   317 SGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSR------GEASNPDFGKTIRDLPLS 375
            ..|....:|:.:..:|:|||.:::..:       |||...|      .|.|..|..||::.|.
  Fly   294 LAAITLVSAILLFMFPKQLPSARKRRL-------QLKQDERKQSLPLNERSLADMMKTVKKLS-- 349

Human   376 IWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLG 440
                 ||..::...:|.............|:||::|:|:..||:.|....|.:.:.....|..:.
  Fly   350 -----KNKVYVYNTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILIS 409

Human   441 GFFVNKLRLRGSAVIKFCLFCTVVSLLGILVF-SLHCPSVPMAG--VTASYGGSLLPEGHLNLTA 502
            |:.::|.:....|:..:......|::.|||.: ::.|.......  .|.|.|.|
  Fly   410 GYVISKYKPSARAMAAWNAIVDFVTVAGILCYVAIGCEGSDRLNTLTTLSAGNS----------- 463

Human   503 PCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQ---NLSSGFGH 564
             |:|:|.|...||:|||.:|.:.:.|.|||||...|:..: |:.:|..|.|:..   |.......
  Fly   464 -CSASCHCDYVHYAPVCSADNITFISACHAGCSERTKDAL-GRTIYTGCECLGSSSLNSEPESQF 526

Human   565 ATAGKCTSTCQRKPLLLVFIFVVIFFTFL---SSIPALTATLRCVRDPQRSFALGIQWIVVRILG 626
            |..|.|...|..:  .|:|:.|:.|...:   |....|...|||:...:::||||:..:...:||
  Fly   527 AVDGTCPVDCFNE--FLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLG 589

Human   627 GIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYIL 668
            .||.||.|||:||..||:|...|..:|:|.:|...:| ||.|
  Fly   590 FIPSPIFFGWLIDNYCLVWGKTCSNKGNCWLYDTKSM-RYAL 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO4A1	XP_011527094.1	MFS_SLCO4A_OATP4A	102..604	CDD:341020	140/532 (26%)
Oatp58Da	NP_611657.2	OATP	67..626	CDD:460821	165/589 (28%)