Protein Alignment SLCO4A1 and Oatp33Eb

DIOPT Version :10

• Sequence 1: XP_011527094.1
• Gene: SLCO4A1 / 28231
• HGNCID: 10953
• Length: 768
• Species: Homo sapiens
• Sequence 2: NP_609570.1
• Gene: Oatp33Eb / 34662
• FlyBaseID: FBgn0032435
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 619
• Identity: 161/619 - (26%)
• Similarity: 261/619 - (42%)
• Gaps: 121/619 - (19%)

Human    83 SVACG----WWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSG 143
            ||.||    .|...|.| |.....:..:..|..:..|||...:.|..:...:        |:|.|
  Fly    24 SVDCGIKGLGWCRGPGC-QKYARLRTFILVLAISGTLQGACESYFRVSAKQA--------SFQFG 79

Human   144 --------LIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALP---HFTAGRY 197
                    |:.:|....|...|.| :|:....|..:||...::|.....:|..:|   :|..|..
  Fly    80 WNPLIVDWLLVASGLFQAVFALAF-AYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQ 143

Human   198 --EVELDAGVRTCPANPGAVCADSTSGLSRYQL------------VFMLGQFLHGVGATPLYTLG 248
              :..|||.          :||.|.:...|..|            :|:| |...|:|....||||
  Fly   144 AKDALLDAN----------MCATSLAQFQRLTLTEAQSSSLTLAMLFVL-QLALGMGGLAYYTLG 197

Human   249 VTYLDENVKSSCSPVYIAIFYTAAILGPAAG-YLIGGALLNIYTEMGRRTELTTESPLWVGAWWV 312
            |:|:|:|..|..||..|.....|.:.|..|| :|:.|..|   |.:|               ||:
  Fly   198 VSYIDDNSLSQDSPAVIGAALAARVFGQQAGSFLVLGVGL---THVG---------------WWL 244

Human   313 GFLGSGAAAFFTAVPILG-YPRQLP------GSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIR 370
            |::......|..|| :|| :|::||      .:||  ::..:.|.:..........:.||..:::
  Fly   245 GWVILAPFIFVGAV-LLGLFPKRLPKTVIHQAAQR--IIEQSSMRRFGSQFSTYMDDSDFWPSLK 306

Human   371 DLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASE---------AATLFG 426
            .| .:..||:    |.||.:.....|.:..|:...|  :|:|:|.|..:|         :|.:..
  Fly   307 RL-FNNRLLM----FNLLSIMCVQSAVVNYGLQEES--YLQSRFFLPYNEQDGLAAEWRSAFVSY 364

Human   427 YLVVPAGGGGTFLGGFFVNKLRLRGSAV--IKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYG 489
            :|..|....|..:.|..::|.:|....:  |...|...:|::...|:| :.|....:|||.   |
  Fly   365 FLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIF-VQCDVGAIAGVE---G 425

Human   490 GSLLPEGHLNLTAP-CNAACSCQPEHYSPVC-GSDGLMYFSLCHAGCPAATETNVDGQKVYRDCS 552
            |        .|..| |::.|.|.|..:.||| .:..:.|||.|:|||  ..:|.::..:::..||
  Fly   426 G--------KLKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGC--TKKTTINSFQLFEGCS 480

Human   553 CI-PQNL-SSGFGHATAGKCTS-TCQRKPLLLVFIFVVIFFTFLSSIPAL---TATLRCVRDPQR 611
            |. .|:| |:|...||||.|:| .||  ..:::|..:.|...||..:.|:   ..|||.|....:
  Fly   481 CSGDQSLNSTGQMRATAGACSSDNCQ--SAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDK 543

Human   612 SFALGIQWIVVRILGGIPGPIAFGWVIDKACLLW 645
            |.||..:.::|.:...:|..:::..|....|:.|
  Fly   544 SLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYW 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO4A1	XP_011527094.1	MFS_SLCO4A_OATP4A	102..604	CDD:341020	142/553 (26%)
Oatp33Eb	NP_609570.1	MFS_SLCO_OATP	46..536	CDD:340894	142/553 (26%)
		PHA03247	<635..813	CDD:223021