Protein Alignment SLCO4A1 and Oatp33Ea

DIOPT Version :9

• Sequence 1: XP_011527094.1
• Gene: SLCO4A1 / 28231
• HGNCID: 10953
• Length: 768
• Species: Homo sapiens
• Sequence 2: NP_001260417.1
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Alignment Length: 705
• Identity: 187/705 - (26%)
• Similarity: 298/705 - (42%)
• Gaps: 136/705 - (19%)

Human    86 CGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYD 150
            ||...:.||.||...|.|..:........:|.|:...||.| :|:||:|:.:.|..:|:|.|..:
  Fly    18 CGMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVT-LTTLEKRFKIPSQTTGIILSGNE 81

Human   151 IAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAG----------RYEVELDAGV 205
            |:..:....:||.||..::|||:.||::..|....:..||||..|          .|:..|..|.
  Fly    82 ISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGT 146

Human   206 RTCP---ANPGAVCADSTSGLSRYQ-------------LVFMLGQFLHGVGATPLYTLGVTYLDE 254
            ....   .|..:|..:...|:.:.:             |:| |.||:.|||.|..|:||.||||:
  Fly   147 TGSDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIF-LSQFVLGVGNTLYYSLGQTYLDD 210

Human   255 NVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGF--LGS 317
            |.|.:.:|:.:|:.....::||..|:..|...||.:.:..:...:.::.|.|:||||:|:  ||:
  Fly   211 NTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPRWLGAWWLGWVILGT 275

Human   318 GAAAFFTAVPILGYPRQLP--GSQRYAVMRAAEMHQLKDSSRGE--------------------- 359
            ....|...:.:  :|:|||  .:.|........:.|.|:..:.|
  Fly   276 LMCLFSGLIGL--FPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAA 338

Human   360 -ASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAAT 423
             .:|.|..| ::|.|.::..||:|...|...|:........:|..||..|::|.||...|..|..
  Fly   339 AGANADLPK-LKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATI 402

Human   424 LFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFS-LHCPSVPMAGVTAS 487
            :.|.:.:.....|....|..::|.:...|.|:.:.:....:|:||.:.:: |:||:.
  Fly   403 IVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNT-------- 459

Human   488 YGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGS-DGLMYFSLCHAGCPAATETNVDGQKVYRDC 551
              .|:...|.||||:.||..|||:...|:|||.. ....:||.|||||.....|:    |:|.||
  Fly   460 --FSMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATS----KLYEDC 518

Human   552 SCI----------------------PQ-------------------------NLSSGFGHATA-- 567
            ||:                      |:                         .|.|....:|:
  Fly   519 SCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDS 583

Human   568 ----GKCTSTCQRK-PLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQRSFALGIQWIVVRILGG 627
                |.||..|... ....:...:|.:|.....:..:....|.|....:|||.|:..:::.:|..
  Fly   584 VIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLAL 648

Human   628 IPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYIL--------IMGLLY 674
            |||||.||.:||..||:|...|...|:|.:|..:.. ||.|        .||||:
  Fly   649 IPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRF-RYSLNFLSCLLTFMGLLF 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLCO4A1	XP_011527094.1	OATP	106..663	CDD:281175	172/664 (26%)
		MFS	106..>489	CDD:119392	110/435 (25%)
		KAZAL_SLC21	500..555	CDD:238650	25/77 (32%)
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	172/666 (26%)
		MFS	40..>280	CDD:119392	70/241 (29%)
		DUF4064	364..447	CDD:290013	18/82 (22%)
		KAZAL_SLC21	470..521	CDD:238650	24/54 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810