Protein Alignment GPD1 and Gpdh2

DIOPT Version :10

• Sequence 1: NP_005267.2
• Gene: GPD1 / 2819
• HGNCID: 4455
• Length: 349
• Species: Homo sapiens
• Sequence 2: NP_611760.2
• Gene: Gpdh2 / 37672
• FlyBaseID: FBgn0034825
• Length: 358
• Species: Drosophila melanogaster
• Alignment Length: 350
• Identity: 159/350 - (45%)
• Similarity: 224/350 - (64%)
• Gaps: 8/350 - (2%)

Human     6 VCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLP 70
            :||:|||||.:.||:.||.|.......|.:|.|:|:||.:.|:||||||||.|.|.||:|..:||
  Fly     6 ICIIGSGNWATTIARNVGRNVLNSQTLDEKVPMYVYEEIVEGRKLTEIINTTHINSKYMPNFELP 70

Human    71 PNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNG-LKLISE 134
            ||:|||.|:|..|.||||:||.:|..|:...|..|.|.:|..|..:|||||.:.|.:| ..|||:
  Fly    71 PNIVAVDDIVTTARDADIIIFAIPPTFVSSCCKTLLGKVKPTAHAVSLIKGFERGDDGQFVLISQ 135

Human   135 VIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEI 199
            :|..:|.||.|||:|.|:|.|:|.:.|.|.|:||:|....::|.::.::|.||:.|.::.|.|||
  Fly   136 IIMRQLKIPCSVLVGCNLAHELAHDHFAEGTVGCRDQKYYRVLHDIFKSPTFRVVVTEDADCVEI 200

Human   200 CGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITT 264
            |..|:|::|..||..||:...:|||..:||.|.:||:.|..:|..| ....||.||||::||:|:
  Fly   201 CSTLRNIIAFAAGCSDGMELNENTKGGIIRRGFLEMLQFVDVFYPG-CRMGTFFESCGISDLVTS 264

Human   265 CYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDKFPLFMAVYKVC 329
            ||..||||:||||.:|||.:.:||..|:.|.:..||.||..::.:|:.|||.||||||..||::|
  Fly   265 CYANRNRKLAEAFVKTGKPLSELEHILIPGHEPLGPVTAELVHHMLKKKGLEDKFPLFTTVYRIC 329

Human   330 YEGQPVGEFIHCLQN------HPEH 348
            ....|:...:..|..      ||.|
  Fly   330 TGDYPLQRLVETLIKAREDIFHPLH 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPD1	NP_005267.2	glycerol3P_DH	5..342	CDD:274551	155/336 (46%)
Gpdh2	NP_611760.2	glycerol3P_DH	6..342	CDD:274551	155/336 (46%)