DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPC1 and dally

DIOPT Version :9

Sequence 1:	NP_002072.2	Gene:	GPC1 / 2817	HGNCID:	4449	Length:	558	Species:	Homo sapiens
Sequence 2:	NP_001246685.1	Gene:	dally / 39013	FlyBaseID:	FBgn0263930	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	127/535 - (23%)
Similarity:	217/535 - (40%)	Gaps:	92/535 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    24 DPASKSRSCGEVRQIYGAKG-FSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELET 87
            |..:|....|...|....|. |...|:..:....|...||  |..||.:..|..|.:::....|.
  Fly    55 DSRAKDAVGGSTHQCDAVKSYFESIDIKSSGTYSEKGAIC--GGNCCNNATELELRDKAAGMFEQ 117

Human    88 ALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSEL--RL 150
            .|...:..|:.:|.|..:.|..|...|...||....:.|...:..:...:......||:|:  .|
  Fly   118 LLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHL 182

Human   151 YY-------------RG---ANLHLEETLAEFWARLLERLFKQLHPQLL---------LPDDYLD 190
            .|             ||   ...:|||.:..|:.    :||...:.|::         |.:||::
  Fly   183 IYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFV----QLFPVAYHQMVHLSKNNLGDLHEDYVN 243

Human   191 CLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV---PLGPECSRAVMK 252
            ||....:.:.|||:.|::::....::...:..|:..|..|::|:.:...:   .|...|...::|
  Fly   244 CLQHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLK 308

Human   253 LVYCAHCLGVPGA-----RPCPDYCRNVLKGCLANQAD-LDAEWRNLLDSM-VLITDKFWGTSGV 310
            :.||.:|.|...:     :.|..||:||::||.|..|. ||:.|..::||: .|:|......:|:
  Fly   309 MHYCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLVTTHILSDTGI 373

Human   311 ESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPS--- 372
            .:||..:.|:.:|||.|...|...|..||.:.||.|.:.|...|          .|..|||.
  Fly   374 INVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSG----------EPDARPPPHKN 428

Human   373 ----------------GTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMAR 421
                            .|::|           .::|:.::....|.|:.  .:..|..||:|...
  Fly   429 NVKWATDPDPGMVLFLSTIDK-----------SKEFYTTIVDNFCDEQQ--HSRDDHSCWSGDRF 480

Human   422 GRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDV----DFQDAS 482
            |.|...::..|..:|..||||..:.......:.:.:.:|..:...:.:|...|.:    |.|  :
  Fly   481 GDYTQLLINPGTDSQRYNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPSNSIQATHDIQ--N 543

Human   483 DDGSGSGSGDGCLDD 497
            |.|.|||.|:|.:.|
  Fly   544 DMGEGSGGGEGQIGD 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPC1	NP_002072.2	Glypican	22..533	CDD:366494	127/535 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..374		9/51 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..534
dally	NP_001246685.1	Glypican	51..622	CDD:279494	127/535 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810