DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GP5 and Toll-6

DIOPT Version :9

Sequence 1:NP_004479.1 Gene:GP5 / 2814 HGNCID:4443 Length:560 Species:Homo sapiens
Sequence 2:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:382 Identity:119/382 - (31%)
Similarity:179/382 - (46%) Gaps:34/382 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    64 VLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLF 128
            ||.:..|..:..|:.|.::::.||.:|....|.|..|:.|.||.|||..||          .:||
  Fly   291 VLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALP----------TELF 345

Human   129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH--LPKGLLG 191
            .:...:             :||:.|..|.:..|...||:||:.|:.||||.|.:|.  :.|....
  Fly   346 AEQAKI-------------IQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFV 397

Human   192 AQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAF 256
            ...:|..|.|..|:|..|:..:.:.|..|..|....|.:.:||...|..:.||.:|.||.|.|.:
  Fly   398 GLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKY 462

Human   257 LPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRY--L 319
            |.:......:.|:||:|..|.|..:....|.....||:|.||..||:|:| .|.||:..||.  |
  Fly   463 LDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVP-LALRNMRHLRTVDL 526

Human   320 GVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFR 384
            |..:   ::.:...||:|||.|..|.|..|.|..:.....|.|..|:.::|.|||:..:....|.
  Fly   527 GENM---ITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFE 588

Human   385 NLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRC-DCGLGP-FLGWLRQH 439
            ..||:::|:||.|:|..:.| :|..:|.|..:.:..|.... |.|..| .|.||..|
  Fly   589 MTSSIQAVRLDGNELNDING-LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLH 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GP5NP_004479.1 LRR 1 75..96 5/20 (25%)
LRR_RI <76..230 CDD:238064 45/155 (29%)
LRR_8 76..134 CDD:290566 18/57 (32%)
leucine-rich repeat 76..99 CDD:275380 7/22 (32%)
LRR 2 99..120 9/20 (45%)
leucine-rich repeat 100..123 CDD:275380 9/22 (41%)
LRR 3 123..144 2/20 (10%)
leucine-rich repeat 124..147 CDD:275380 2/22 (9%)
LRR_8 147..206 CDD:290566 21/60 (35%)
LRR 4 147..168 7/20 (35%)
leucine-rich repeat 148..171 CDD:275380 9/22 (41%)
LRR_RI 163..400 CDD:238064 80/240 (33%)
LRR 5 171..193 8/23 (35%)
leucine-rich repeat 172..195 CDD:275380 8/24 (33%)
LRR_8 195..254 CDD:290566 19/58 (33%)
LRR 6 195..216 6/20 (30%)
leucine-rich repeat 196..219 CDD:275380 7/22 (32%)
LRR 7 219..240 6/20 (30%)
leucine-rich repeat 220..243 CDD:275380 6/22 (27%)
LRR_8 242..302 CDD:290566 20/59 (34%)
LRR 8 243..264 8/20 (40%)
leucine-rich repeat 244..267 CDD:275380 7/22 (32%)
LRR 9 267..288 7/20 (35%)
leucine-rich repeat 268..291 CDD:275380 7/22 (32%)
LRR 10 291..312 10/20 (50%)
leucine-rich repeat 292..315 CDD:275380 12/22 (55%)
LRR_8 314..375 CDD:290566 20/62 (32%)
leucine-rich repeat 316..338 CDD:275380 6/23 (26%)
LRR 11 340..361 5/20 (25%)
leucine-rich repeat 341..364 CDD:275380 7/22 (32%)
LRR_8 364..421 CDD:290566 17/56 (30%)
LRR 12 364..385 6/20 (30%)
leucine-rich repeat 365..388 CDD:275380 6/22 (27%)
LRR 13 388..409 8/20 (40%)
leucine-rich repeat 389..410 CDD:275380 7/20 (35%)
LRRCT 421..472 CDD:214507 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 469..498
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 59/199 (30%)
leucine-rich repeat 279..302 CDD:275380 3/10 (30%)
LRR_8 301..386 CDD:290566 33/107 (31%)
leucine-rich repeat 303..326 CDD:275380 7/22 (32%)
leucine-rich repeat 327..350 CDD:275380 11/32 (34%)
LRR 350..729 CDD:227223 98/313 (31%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 74/229 (32%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 7/22 (32%)
leucine-rich repeat 498..518 CDD:275380 11/20 (55%)
leucine-rich repeat 521..544 CDD:275380 8/25 (32%)
leucine-rich repeat 545..566 CDD:275380 6/20 (30%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 7/22 (32%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 4/7 (57%)
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8435
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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