DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GP2 and Gp2

DIOPT Version :9

Sequence 1:	NP_001007241.2	Gene:	GP2 / 2813	HGNCID:	4441	Length:	537	Species:	Homo sapiens
Sequence 2:	XP_006508184.1	Gene:	Gp2 / 67133	MGIID:	1914383	Length:	551	Species:	Mus musculus

Alignment Length:	541	Identity:	361/541 - (66%)
Similarity:	422/541 - (78%)	Gaps:	11/541 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     3 HLMERMVGSGLLWLALVSCILT--QASAVQRGYGNPIEASSYGLDLDCGAPGTPEAHVCFDPCQN 65
            |.|:||||..|||||..||:||  ..|.:.:|||.|..:|:  ||||||:|.:|.:.:|||||||
Mouse    16 HFMKRMVGCDLLWLAAASCVLTLVSPSTIHQGYGRPRNSSN--LDLDCGSPDSPSSGICFDPCQN 78

Human    66 YTLLDEPFRSTENSAGSQG-CDKNMSGWYRFVGEGGVRMSETCVQVHRCQTDAPMWLNGTHPALG 129
            :|:|::|.|||||:..|.. ||.|:.|||||||:|||:|.||||.|.||.|.|||||:|:||.||
Mouse    79 HTVLNDPTRSTENNDSSVAWCDDNLHGWYRFVGDGGVKMPETCVSVFRCHTSAPMWLSGSHPILG 143

Human   130 DGITNHTACAHWSGNCCFWKTEVLVKACP---GGYHVYRLEGTPWCNLRYCTVPRDPSTVEDKCE 191
            |||.:|||||:|:.|||||::||.||||.   |.||||:|:|||.|:|||||   ||||....||
Mouse   144 DGIVSHTACANWNENCCFWRSEVQVKACSEELGEYHVYKLQGTPECSLRYCT---DPSTAPKNCE 205

Human   192 KACRPEEECLALNSTWGCFCRQDLNSSDVHSLQPQLDCGPREIKVKVDKCLLGGLGLGEEVIAYL 256
            ..|||||||:..|:.|.|.|||||:.||..||||.||||..|||||:|||||||:|..||:||||
Mouse   206 ITCRPEEECVFQNNNWSCVCRQDLHVSDSQSLQPLLDCGDNEIKVKLDKCLLGGMGFKEEIIAYL 270

Human   257 RDPNCSSILQTEERNWVSVTSPVQASACRNILERNQTHAIYKNTLSLVNDFIIRDTILNINFQCA 321
            .|.||:..:|.|..||||:||||.|:.|.||||:|.|||||:|||||..||||||..:|:|||||
Mouse   271 NDRNCNGTMQDEPNNWVSMTSPVVANYCGNILEKNGTHAIYRNTLSLATDFIIRDFRVNVNFQCA 335

Human   322 YPLDMKVSLQAALQPIVSSLNVSVDGNGEFIVRMALFQDQNYTNPYEGDAVELSVESVLYVGAIL 386
            |||||.|||:.|||||||||.|.|||.|||.|:|||||||:|||||||..|.|.|||:||||.:|
Mouse   336 YPLDMSVSLETALQPIVSSLTVDVDGAGEFNVKMALFQDQSYTNPYEGAEVLLPVESILYVGVLL 400

Human   387 EQGDTSRFNLVLRNCYATPTEDKADLVKYFIIRNSCSNQRDSTIHVEENGQSSESRFSVQMFMFA 451
            .:||||||.|:|.||||||:||:.|.||||||:|.|.|||||||:|.|||.||||||||||||||
Mouse   401 NRGDTSRFKLLLTNCYATPSEDRHDPVKYFIIKNRCPNQRDSTINVRENGVSSESRFSVQMFMFA 465

Human   452 GHYDLVFLHCEIHLCDSLNEQCQPSCSRSQVRSEVPAIDLARVLDLGPITRRGAQSPGVMNGTPS 516
            |:|||||||||::||||..||||||||.:::||..||||..|||||||||:|.|||.....|||.
Mouse   466 GNYDLVFLHCEVYLCDSTTEQCQPSCSTNRLRSSRPAIDYNRVLDLGPITKRSAQSSATSKGTPH 530

Human   517 TAGFLVAWPMVLLTVLLAWLF 537
            |.|||:||||..|.|.||.||
Mouse   531 TTGFLLAWPMFFLPVFLALLF 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GP2	NP_001007241.2	ZP	229..480	CDD:214579	184/250 (74%)
GP2	NP_001007241.2	Zona_pellucida	358..478	CDD:278526	91/119 (76%)
Gp2	XP_006508184.1	Zona_pellucida	243..492	CDD:365872	182/248 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83970137
Domainoid	1	1.000	383	1.000	Domainoid score	I12014
eggNOG	1	0.900	-	-		E1_28KQA
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133790
Inparanoid	1	1.050	746	1.000	Inparanoid score	I8623
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38122
OrthoDB	1	1.010	-	-		D110098at40674
OrthoFinder	1	1.000	-	-		FOG0001512
OrthoInspector	1	1.000	-	-		oto127472
orthoMCL	1	0.900	-	-		OOG6_106287
Panther	1	1.100	-	-	LDO	PTHR14002
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8665
SonicParanoid	1	1.000	-	-		X726
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300