DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GP2 and mua-3

DIOPT Version :9

Sequence 1:	NP_001007241.2	Gene:	GP2 / 2813	HGNCID:	4441	Length:	537	Species:	Homo sapiens
Sequence 2:	NP_001022674.1	Gene:	mua-3 / 176430	WormBaseID:	WBGene00003482	Length:	3767	Species:	Caenorhabditis elegans

Alignment Length:	267	Identity:	58/267 - (21%)
Similarity:	91/267 - (34%)	Gaps:	100/267 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    56 AHVCFDPCQNYTL--------LDE---PFRSTEN-------SAGSQGCDKNMSGWYRFVGEGGVR 102
            || |.|..:.|:.        :||   |.|..|.       |.|...||:|
Worm  1724 AH-CIDTIEGYSCICKPGFVDMDEFGNPGRRCEQIKTNDKCSPGKNDCDRN-------------- 1773

Human   103 MSETCVQVHRCQTDAPMWLNGTHPALGDGITNHTACAHWSGNCCFWKTEVLVKACPGGYHVYRLE 167
              ..|:|:                  ||   :..:|                 |||.|:.    :
Worm  1774 --ARCIQI------------------GD---DDYSC-----------------ACPPGFK----D 1794

Human   168 GTPWCNL--RYC--TVPR-DPSTVEDKCEKACRPEEECLALNSTWGCFCRQD-LNSSDVHSLQPQ 226
            .:|..:.  |.|  .:|. |..|:.| |:...|  ..|...:..:.|.|||. |:.|...|::|.
Worm  1795 KSPSSSRPGRLCIPVIPECDNPTLND-CDSPDR--AVCTDTDDGYMCRCRQGFLDISPSISVKPG 1856

Human   227 LDCGP--REIKVKVDKCLLGGLGLGEEVIAYLRDPN---CSSILQTEERNWVSVTSPVQASACRN 286
            ..|.|  .|..:.:|.|...| |:.|:      :|:   |...:...:.::..||.|  ...|:.
Worm  1857 RLCKPLQNECALGIDDCARDG-GICED------NPDSFTCRCAMNYLDVSFDRVTRP--GRKCKR 1912

Human   287 ILERNQT 293
            ::...||
Worm  1913 LINECQT 1919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GP2	NP_001007241.2	ZP	229..480	CDD:214579	16/70 (23%)
GP2	NP_001007241.2	Zona_pellucida	358..478	CDD:278526
mua-3	NP_001022674.1	LDLa	32..60	CDD:238060
		LDLa	131..164	CDD:238060
		EGF_3	766..795	CDD:289699
		vWA_collagen_alphaI-XII-like	1229..1398	CDD:238759
		EGF_3	1662..1691	CDD:289699
		EGF_CA	1709..1755	CDD:214542	9/31 (29%)
		EGF_CA	1964..1997	CDD:214542
		SEA	2873..2998	CDD:214554
		SEA	3049..3173	CDD:214554
		EGF_CA	3328..3364	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910