DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GP2 and B0393.5

DIOPT Version :9

Sequence 1:	NP_001007241.2	Gene:	GP2 / 2813	HGNCID:	4441	Length:	537	Species:	Homo sapiens
Sequence 2:	NP_497982.2	Gene:	B0393.5 / 175632	WormBaseID:	WBGene00007170	Length:	1183	Species:	Caenorhabditis elegans

Alignment Length:	520	Identity:	104/520 - (20%)
Similarity:	164/520 - (31%)	Gaps:	176/520 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    42 YGLDLDCGAPGTPEAHVCFDPCQNYTLLDEPFRSTENSAGSQGCDKNMSGWYRFVGEGGVRMSET 106
            |.:| :|..||.        .|:::::       ..|:.||..|  ...|.|||  |.|     .
Worm   478 YDVD-ECEIPGA--------VCRDHSI-------CSNTIGSFEC--TCHGGYRF--EDG-----K 517

Human   107 CVQVHRCQTDAPMWLNGTHPALGDGITNHTACAHWSGNCCFWKTEVLVKACPGGYHVYRLEGTPW 171
            |..|..|: :.|       ...||  .|       .|..|..|.......|..||     ||.|.
Worm   518 CEDVDECR-ELP-------KICGD--PN-------KGTKCINKDGTFECLCKDGY-----EGDPS 560

Human   172 CNLRYCTVPRDPSTVEDKCEKACRPEEECLALNSTWGCFCR------------QDLNSSDVHSLQ 224
            ...|.....::|.        ||.|..:|......:.|.|.            .|.:...|....
Worm   561 SECRDVNECKNPD--------ACGPNSQCTNTQGGYECECLAGFERIAEGAHCTDRDECAVEPCH 617

Human   225 PQLDCGPREIKVKVDKCLLGGLGLGE---EVIAYLRDP--NCSSILQTEERNWVSVTS-PVQA-- 281
            |...|.......|.: |..|.:|.|:   |.|.|   |  |.|:::   .|:|.|.|: |:.:
Worm   618 PAAICSNTRGSYKCE-CRDGFVGDGKTCHETILY---PISNDSTVI---PRSWDSSTAVPILSEI 675

Human   282 ---------------------SACRNILERNQT---------HAIYKNTLSLVNDFIIRDTILNI 316
                                 ...:.:::..:|         ||.:    ..:.:.::..|.:|.
Worm   676 TIFGKKYSKIYLSTNGIISFDGPLQGLIDHAETLKKPAIFALHAQF----DYIREGLVAYTFIND 736

Human   317 NFQCAYPLDMKVSLQAALQPIVSSLNVSVDGNGEFIVRMALFQ--------DQNYTN------PY 367
            ......||.|:.|:  .:|..:...|....       |:.:|.        .:|:.:      ..
Worm   737 TDAVTLPLLMRSSI--GIQTAMGIENFQTK-------RLHIFTFDRVRQSGSENFNSFQIVLAES 792

Human   368 EGDAVELSV--ESVLYVGAILEQGDTSRFNLVLRNCYATPTE-----------DKADLVKYFIIR 419
            :.||..||:  |.|...|.:......|||.::..|..|:.:.           |.|||
Worm   793 DKDATILSLIYEKVQARGPMTGISTPSRFLMLPNNRLASGSNVGQPGKWMYRVDIADL------- 850

Human   420 NSCSNQRDSTIHVEENGQSSESRFSVQMFMFAGHYDL---VFLHCEIHL-CDSLNEQCQPSCSRS 480
            .:|...|        .|:....|...     ||||.:   ...||:..: ||.:...|..:..|:
Worm   851 QTCPPGR--------LGEPLCDRECA-----AGHYGINCESTCHCDGSVACDVITGMCPGALCRA 902

Human 481 480
Worm 903 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GP2	NP_001007241.2	ZP	229..480	CDD:214579	60/319 (19%)
GP2	NP_001007241.2	Zona_pellucida	358..478	CDD:278526	31/150 (21%)
B0393.5	NP_497982.2	NIDO	120..255	CDD:214712
		EGF_3	453..477	CDD:289699
		EGF_CA	479..>512	CDD:284955	10/50 (20%)
		EGF_CA	520..563	CDD:284955	15/64 (23%)
		EGF_CA	565..606	CDD:214542	7/48 (15%)
		EGF_3	611..644	CDD:289699	8/33 (24%)
		NIDO	714..850	CDD:214712	27/148 (18%)
		EGF_CA	912..952	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910