DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsun2 and Nsun2

DIOPT Version :9

Sequence 1:	NP_663329.3	Gene:	Nsun2 / 28114	MGIID:	107252	Length:	757	Species:	Mus musculus
Sequence 2:	NP_652007.1	Gene:	Nsun2 / 45064	FlyBaseID:	FBgn0026079	Length:	746	Species:	Drosophila melanogaster

Alignment Length:	768	Identity:	323/768 - (42%)
Similarity:	441/768 - (57%)	Gaps:	84/768 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MGRRARGRRFQQPPQPEGEEDASDGGRKRGQAGWEGGYPEIVKENKLFEHYYQELKI-VPEGEWD 64
            |||..:...|....:.:.|     .|.||.....: .|.||.::|..|..|||..|| ..:.||.
  Fly     1 MGRNQKQNFFAARKRQKRE-----NGPKRTDRQAQ-PYEEIKRDNAFFIKYYQLQKICATDEEWT 59

Mouse    65 QFMESLREPLPATLRITGYKSHAKEILHCLKNKYFKE----LEDLEVDG-QKVEVPQPLSWYPEE 124
            ||:.|:|:.||.|.|:||:|..||.:|..::.:.|.|    :.:|.... :.||.|..|.|||..
  Fly    60 QFLASIRDNLPTTFRVTGFKDEAKALLSIIETQLFTEYVRAVAELHQKAPEDVERPLCLPWYPNG 124

Mouse   125 LAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSMIPPLLLNVEPHHKILDMCAAPGS 189
            ||:..:|:||.:|:|..|.:.|.||:.||.:|.||||||||||||::|:|.|..|:|||||||||
  Fly   125 LAYQLHLTRKDIRRSEPLYRLHNFLIVETTAGGISRQEAVSMIPPIVLDVRPTDKVLDMCAAPGS 189

Mouse   190 KTTQLIEMLHADMSVP----FPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRL- 249
            ||.||||.|||   .|    .|.|||:||||||.|||:||||||||:|||::|.|||:|..|.|
  Fly   190 KTAQLIEALHA---APEEHKIPPGFVLANDVDNNRCYMLVHQAKRLNSPCLLVTNHDSSVFPNLV 251

Mouse   250 TVDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGG 314
            |...||.|.||.:|:||||||||||||:|||.|:|.||....:..|||:|.||..||||.|..||
  Fly   252 TTKPDGSKAILKFDKILCDVPCSGDGTLRKNPDIWLKWNLAQAYNLHGIQYRIVRRGAEMLEVGG 316

Mouse   315 RMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMPGVSQWKVMTRD-GQWFADWH 378
            |:|||||||||:|:|||:..:::.::|||||.|....:||||:.||::.||:.|:: .|.|..:.
  Fly   317 RLVYSTCSLNPIENEAVLQRIIKDADGALELVDAGHLVPGLKYKPGMTDWKLATKEVDQIFTRFE 381

Mouse   379 EVPQGRHTQIRPTMFP-PTDLEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKAPMPWNKRQ-PK 441
            |||:..||.|||.||| |.|  ::..:.||:|||:|||.|::||||||||.|:..:.:.|.. .:
  Fly   382 EVPESLHTIIRPGMFPLPAD--EMAKIGLEKCLRVLPHLQDSGGFFVAVLEKRRQLSFEKNDVVE 444

Mouse   442 VQNKSAEAREPRVSSHVAATEGNPSDQSELESQMITGAGDSETAHNTENTESNEKKDGVCGPPPS 506
            :...:..|::|.....|.| :|.|.::.                             .|...|..
  Fly   445 LVKLNETAKQPAAEPQVDA-DGKPIEEK-----------------------------SVPWGPQR 479

Mouse   507 KKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLL 571
            ||.:|.|:||||:||..|:||.:..|::||.||.|..:..||||....||:.:|..|:.:|:::|
  Fly   480 KKRRLHGYKEDPYVFFGENDPDYQAIKEFYQLDESLSQRCLLTRCVTEKKKNIYYCSEPIRDLVL 544

Mouse   572 NNSEKMKVINTGIK--VWCRNNSGEEFDCAFRLAQEGIYTLYPFIN-SRIITVSMEDVKTLLT-- 631
            ||...:|:||||:|  |.|.|.....   .|||||||:.|...|:. ||.|.|..||:..:|.
  Fly   545 NNENNIKIINTGVKTFVRCENRHTVH---PFRLAQEGLQTSNAFMGASRRIQVEREDLVMMLNCT 606

Mouse   632 --QENPFFRKLSSEAYSQVKDLAKGSVVLKYEPDSANPDTLQCPIVLCGWRGKASIRTFVPKNER 694
              .:.|...:|..|...:.|:|..||.:|||...       :..:...||||.:|:|.:|.|:|.
  Fly   607 DPTQPPSTHELKKETQERCKELGVGSCILKYVDQ-------RFTLYTVGWRGTSSLRAYVQKDET 664

Mouse   695 LHYLRMMG--LEVLGEKKKEGVILTNENAASPE----------QPGDEDAKQT 735
            :|.||::|  |......|.|...:....||..|          ..||.||.::
  Fly   665 IHILRLLGADLSKFETNKYEDARVAAAAAADAEVGKSAEAEADSSGDGDATES 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsun2	NP_663329.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		8/33 (24%)
		RsmB	28..430	CDD:223222	218/414 (53%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01023	184..190		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..504		8/68 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..757		7/30 (23%)
Nsun2	NP_652007.1	RsmB	13..433	CDD:223222	221/432 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836959
Domainoid	1	1.000	308	1.000	Domainoid score	I1335
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9817
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1175
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54313
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002888
OrthoInspector	1	1.000	-	-		oto93457
orthoMCL	1	0.900	-	-		OOG6_101428
Panther	1	1.100	-	-	LDO	PTHR22808
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2247
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760