DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GOLGB1 and Golgin245

DIOPT Version :9

Sequence 1:NP_001243415.1 Gene:GOLGB1 / 2804 HGNCID:4429 Length:3269 Species:Homo sapiens
Sequence 2:NP_611787.2 Gene:Golgin245 / 37702 FlyBaseID:FBgn0034854 Length:1489 Species:Drosophila melanogaster


Alignment Length:1819 Identity:390/1819 - (21%)
Similarity:744/1819 - (40%) Gaps:429/1819 - (23%)


- Green bases have known domain annotations that are detailed below.


Human  1309 VAQIKAQLKEIEAEKVELELKVSSTTSEL------TKKSEEVFQLQEQINKQG--LEIESLKTVS 1365
            :.::||...:.:......:..|||::|..      |..:|..|.:.|:...|.  ..|:.|...|
  Fly    10 IEEVKASPSKFQQFANAAQAAVSSSSSTTPNSETNTSNNENFFSITEEDTPQNSPYRIQKLPATS 74

Human  1366 HEAEVHAESLQ---------QKLESSQL-----------QIAGLEHLRELQPKLDELQKLISKKE 1410
            ..| :...|.|         :||.:|.:           :...:.|   ||..|||..       
  Fly    75 ASA-LRGRSTQSLNGATSRTRKLSNSSMASDVSFRLPTYEAPAVYH---LQSDLDETS------- 128

Human  1411 EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1475
                      ||.:.:.:..:.::|.::.|..|....|        :|..:.:....::.:|.:|
  Fly   129 ----------SEFDDSASTARLDVITKDQLYDAYKKSL--------DRYHKYRCRYTDLAKKYKE 175

Human  1476 IGEESRAKQQIQRKLQAALI-SRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1539
            :..:|       .|.::.|: ::.:||:....|:|:.:|               |.|..|..:| 
  Fly   176 LERDS-------SKARSVLVETQDKALRRISELREQCTL---------------EQQAKAHLEE- 217

Human  1540 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE--GLTEDKEKLVKEIESLKSSK 1602
                    .|:.|.|.:..:|.....:.|.|..:.|::..|||  |...:.|:|:...||:..|.
  Fly   218 --------ALRVEMDDMSCKMQAYQTKLQLLGENPENITAALERSGQQLESEQLIDLEESIGKSP 274

Human  1603 IAES-----TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1662
            ::.:     ::.|...||..::.:.:.:.||.|..:.|  ::|: .:.|.||.::     ||...
  Fly   275 LSTNGSSGVSDLQRLLKERDEQLKSVTEKYEAVRKQEE--ENVL-LLAQTKQAIH-----TELEL 331

Human  1663 KETE-KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND-RLRAEVHPAGDTAKECMETLLSS 1725
            |:|| ::|||..:::|..:|......|.:.:|:...::|.| :|.|..|.. :|.||........
  Fly   332 KDTEVRKLQEKLKQLESQRESHNNEVKEQFKKLQATKQEVDAKLMATEHLL-NTLKESYAIKEQQ 395

Human  1726 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNV 1790
            ..:::.:||.:::|.|                 ::|:||:.|             .|..:.|.:.
  Fly   396 VVTLEAQLEAIRVENE-----------------QKVKDLQKQ-------------NEDRNTQASD 430

Human  1791 TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1855
            :.|..:.:....::.:|..:| :....||:.|.::|..                ||:..|||::.
  Fly   431 SSEQLKKLQAAVQDAESQLLS-KDQLLESLRSEQAAKE----------------QQLKHLKEQLG 478

Human  1856 GLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1920
            .|   ||:|:.:...|...|.:..||.:....:.|.||                           
  Fly   479 KL---KQENENYLDKLRENKKSSDSQTNEAQDQQKKLQ--------------------------- 513

Human  1921 EEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT 1985
             ..||:.|.:|: ...||..|:.|   |....:.|..|||.::|.|.| .:::..||...:.|:.
  Fly   514 -AAKDEAESKLL-ATEELLHSLRN---DYKAQEEKVALLEDKLKTLSK-ENDVNVEKLHHINEQR 572

Human  1986 KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL 2050
            :.:|...::.:.:::.|:.|    :.||     |...:..:..||......:|:.::||:::.||
  Fly   573 EAQSTDSQQKINELRAAKDE----AEAK-----LLSTEHSLNALQAALSAKEEQAASLEQSLNAL 628

Human  2051 EFVQTESQKDLEITKENLAQAVEHRKKA--QAELASFKVLLDDTQSEA---ARVLADNLKLKKE- 2109
            :.....|.:||.:..:.|.:.|:..::.  :|:||..:..|...||:.   |..|..:|::::| 
  Fly   629 KTESEHSLQDLRLHNDQLLEIVQRHQQNDWEAQLARAREELAAIQSQRELHALELEKSLEMERES 693

Human  2110 ---LQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2171
               |.|.|.|.:.|.:.|.|.|:|.::..:::|...:   .|.:.||:.:...|.:.:...|.:|
  Fly   694 VAALNSEKASQEEQHRLKLEQLQREIQILQDQHANSE---SETVAALKGQLEALSQDLATSQASL 755

Human  2172 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED 2236
            ..|:||::.....|:....|.... ::.||.|..|...:..........|..::|::||::.:  
  Fly   756 LAKEKELKASGNKLNKIKKQHEQH-QAKSSDQSARLEALQSELADRLSHSRQVESEKEELQAR-- 817

Human  2237 NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT-------------LQ 2288
             .:.:.:::..|...|::::.:.|.||.:|:..||:.::   |||:..|:             :|
  Fly   818 -VTGILEEIGTMQAQMQQVQDSHSELEREKRKLESRIES---LQQEQVDSSAQDERTSAKLEEIQ 878

Human  2289 GENKELLSQ---LEE-TRHL---YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI 2346
            .||.:|..:   ||| |.||   ..:.|:|:.|::::|:.:.|:.:.|.|:.|........|:..
  Fly   879 SENTKLAERNCLLEEQTNHLESQLQAKQDEIGKIQAKLQQVLDEHSKLQNAQELMDHDHRTLQDK 943

Human  2347 IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2411
            ....|.|...:|.:.:.|::..:....:.:.|..|:..::|:               ::|||::.
  Fly   944 CDAYEKDKLLTKHTLDCLQSASEELHRVKANLDRELKEQDQQ---------------LSELRERQ 993

Human  2412 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK---------KENIQQKAQL--D 2465
                :|.|..|..:.|....|:.:|.   :...||..|:..::         ::.||:|.|.  .
  Fly   994 ----REQEQQLKDQAERCAKLKAQNS---ESETQLQATISNLREQLDAYKQTEQGIQEKLQATNS 1051

Human  2466 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2530
            |:...:::|:........|.::|.|.:.::.||.:||..:...|..::||.|             
  Fly  1052 SYTTQIATLEARWSAANSDVERLHEANDALQLEMEQLKIKHGQEREEVKESI------------- 1103

Human  2531 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSF 2595
             |:.:.:::    :|.:.:..:|.        |||:..|...|.||.:|.|.|:|..|:..:: .
  Fly  1104 -AQKNRQVV----ELQEAMATRDR--------QLQEKIEASEKLAKFDEILIENEYLNKHTKQ-L 1154

Human  2596 NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA-QLKVKEEEVHRLSALFSSSQKR 2659
            .|...|..:|.::::||:.       ::..|||:..   .|| |:..||.:....:|..|..:|.
  Fly  1155 EAELAESAELKEKLKSLQC-------ELYVLQEKAE---QHAVQMAEKETQSATATAEVSELKKA 1209

Human  2660 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2724
            |.|...||. .|||.|..|.|..|.::|                            ||::.:|:|
  Fly  1210 IEEQAVELT-RQKEHASFVTEQSDAVQK----------------------------DLLQAQQQL 1245

Human  2725 LMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDAL 2789
                 .:|    ||:        |..|||                        ||.||..|.|.|
  Fly  1246 -----HDK----QIE--------LAMSRD------------------------EQALLQAEADGL 1269

Human  2790 LSETAFSMN----STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2850
            ..|......    ||:.:|   |..||::|..:.|.|.|.|:..|.  |..|...:..|:.|...
  Fly  1270 RQEVICLKEHLSPSTDSDS---LRSLNERLQRELEDLKHKSAGAES--NMQQEIEELQANNQQMA 1329

Human  2851 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE 2915
            :.: ||||..|...:.:|..|   |.:|..||  :.|.:..:.:.:..|||:.|           
  Fly  1330 ERI-NELETLRAGIQAQQLLA---SMAPKNVQ--EAAAAGEKAELESKLKEIMN----------- 1377

Human  2916 ITELHPLKAQLQEYQDKTKAFQIMQEELRQEN---LSWQHELHQLRMEKSSWEIHERRMKEQYLM 2977
                        |.||.|.....::::.  ||   |...:|..:|:..|.|.::.|..:..|:..
  Fly  1378 ------------EVQDVTNRNLFLEQKC--ENFLILEQSNERLKLQNAKLSRQLDETLVSMQHSE 1428

Human  2978 AISDKDQQLSHLQNLIRELRSSSSQTQPL-KVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3040
            |: ..:.:..:|:|::.:..:.::..:.| ||     .|.....||..:|..:.:....|:.||
  Fly  1429 AV-PANTEFEYLRNIMFQYLTGNTNNETLVKV-----ISAVLKFSPQQAQVALEKEHQRRSLLN 1486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GOLGB1NP_001243415.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..142
SMC_prok_B 223..1038 CDD:274008
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..657
Smc 814..1650 CDD:224117 73/376 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 949..968
Ax_dynein_light <1160..1223 CDD:287215
Myosin_tail_1 1394..2326 CDD:279860 209/970 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1752..1834 13/81 (16%)
SMC_prok_B 1904..2778 CDD:274008 197/914 (22%)
SMC_prok_B 2459..3192 CDD:274008 136/593 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2861..2881 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3003..3026 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3117..3150
Golgin245NP_611787.2 Smc 286..1089 CDD:224117 202/935 (22%)
Phage_GPO <306..421 CDD:301727 34/153 (22%)
Smc 737..1442 CDD:224117 193/877 (22%)
MIT_CorA-like <1244..>1333 CDD:294313 32/135 (24%)
Grip 1433..1477 CDD:197860 9/48 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
10.960

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