Protein Alignment GOLGA4 and Golgin245

DIOPT Version :9

• Sequence 1: XP_005265126.1
• Gene: GOLGA4 / 2803
• HGNCID: 4427
• Length: 2285
• Species: Homo sapiens
• Sequence 2: NP_611787.2
• Gene: Golgin245 / 37702
• FlyBaseID: FBgn0034854
• Length: 1489
• Species: Drosophila melanogaster
• Alignment Length: 2313
• Identity: 479/2313 - (20%)
• Similarity: 850/2313 - (36%)
• Gaps: 871/2313 - (37%)

Human     1 MFKKLKQKISEEQ-------QQLQQALAPAQASSNSSTPT--RMRSRTSSFTEQLDEGTPNRELL 56
            ||..||.|:.||.       ||...|...|.:||:|:||.  ...|...:|....:|.||..
  Fly     1 MFANLKNKLIEEVKASPSKFQQFANAAQAAVSSSSSTTPNSETNTSNNENFFSITEEDTPQN--- 62

Human    57 AGMIAEPAFLSEYTIFALDSSKHPKTQSDSVNASTHASKSPDSVNGSEPSIPQSGDTQSFAQKLQ 121
                      |.|.|     .|.|.|     :||....:|..|:||: .|..:.....|.|..:.
  Fly    63 ----------SPYRI-----QKLPAT-----SASALRGRSTQSLNGA-TSRTRKLSNSSMASDVS 106

Human   122 LRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNS 186
            .|:|:.|:       .:::...|                |||.:::.||     ||.:   ....
  Fly   107 FRLPTYEA-------PAVYHLQS----------------DLDETSSEFD-----DSAS---TARL 140

Human   187 DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREEL 251
            |.:.|:||....::.......||.:|::|...|:.|:|:..|.:.:|.::|||:||||:||||:.
  Fly   141 DVITKDQLYDAYKKSLDRYHKYRCRYTDLAKKYKELERDSSKARSVLVETQDKALRRISELREQC 205

Human   252 QMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKE 316
            .::||||.||:|.....:::....:...||::.||                             .
  Fly   206 TLEQQAKAHLEEALRVEMDDMSCKMQAYQTKLQLL-----------------------------G 241

Human   317 ENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER 381
            ||||:....:...|..:::    :|.:..:|::.|            ..|.|:....:.:
  Fly   242 ENPENITAALERSGQQLES----EQLIDLEESIGK------------SPLSTNGSSGVSD----- 285

Human   382 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRI 446
            ||.|.|.:|    |:.|.:|:..:|   :.:.|::..:::|:||:.:|..||:|:.|:.:|:.::
  Fly   286 LQRLLKERD----EQLKSVTEKYEA---VRKQEEENVLLLAQTKQAIHTELELKDTEVRKLQEKL 343

Human   447 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQ 511
            ||:.:|                                |.....|:.||.|.::.|.:|
  Fly   344 KQLESQ--------------------------------RESHNNEVKEQFKKLQATKQE------ 370

Human   512 QELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSE 576
                      ||....::|..:..|::.:    |.|||::.
  Fly   371 ----------VDAKLMATEHLLNTLKESY----AIKEQQVV------------------------ 397

Human   577 YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEK---SLQEN 638
                             .||.|.:||..|:|.|::|||::.|...|:..:....|:|   ::|:.
  Fly   398 -----------------TLEAQLEAIRVENEQKVKDLQKQNEDRNTQASDSSEQLKKLQAAVQDA 445

Human   639 KNQ--SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 701
            ::|  |||                 .::|..::| ::.|.||.....|:|..|||:.:..::|||
  Fly   446 ESQLLSKD-----------------QLLESLRSE-QAAKEQQLKHLKEQLGKLKQENENYLDKLR 492

Human   702 E--KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSV 764
            |  |....:....:|::...||..:|...|.|            .:.||...|:..:|.:||...
  Fly   493 ENKKSSDSQTNEAQDQQKKLQAAKDEAESKLL------------ATEELLHSLRNDYKAQEEKVA 545

Human   765 LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 829
            |.:  ||:|                   ::.||::|::::..     .||:      :|:....:
  Fly   546 LLE--DKLK-------------------TLSKENDVNVEKLH-----HINE------QREAQSTD 578

Human   830 HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLT 894
            .|..:..|.|....:|.:|......|:..|:..||.       |||.|.|:|.|..|:||
  Fly   579 SQQKINELRAAKDEAEAKLLSTEHSLNALQAALSAK-------EEQAASLEQSLNALKTE----- 631

Human   895 KQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 959
               :|...|      :|..|..|:.:::|: .:||.            :|::|.   :.:|:...
  Fly   632 ---SEHSLQ------DLRLHNDQLLEIVQR-HQQND------------WEAQLA---RAREELAA 671

Human   960 ILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQET 1024
            |..::|...|:           |.:.|..:.:|:..||.|..::.:....|:|:::::.:.:|:.
  Fly   672 IQSQRELHALE-----------LEKSLEMERESVAALNSEKASQEEQHRLKLEQLQREIQILQDQ 725

Human  1025 LKKKLLDQEAKLKKELENTALELS-------QKEKQFNA---------KMLEMAQANSAGISDAV 1073
            ......:..|.||.:||..:.:|:       .|||:..|         |..|..||.|   ||..
  Fly   726 HANSESETVAALKGQLEALSQDLATSQASLLAKEKELKASGNKLNKIKKQHEQHQAKS---SDQS 787

Human  1074 SRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1138
            :|||..|.|..:.|:  |.|::..
  Fly   788 ARLEALQSELADRLS--HSRQVES----------------------------------------- 809

Human  1139 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK 1203
              ||||:...:|.:.||       :..:|.|::|.....:.|.:::.||::.:|.|:
  Fly   810 --EKEELQARVTGILEE-------IGTMQAQMQQVQDSHSELEREKRKLESRIESLQ-------- 857

Human  1204 ENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1268
                 |||:..    :.:|:|..::|        ||.||                 |..||:|.
  Fly   858 -----QEQVDS----SAQDERTSAKL--------EEIQS-----------------ENTKLAER- 887

Human  1269 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQL 1333
                       ..|||.:||.|                         :..|..|...:.:::|:|
  Fly   888 -----------NCLLEEQTNHL-------------------------ESQLQAKQDEIGKIQAKL 916

Human  1334 RQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQ 1398
            :|:.:|.:.|     |...:|.:.:::....|.|                     |.||:..:|:
  Fly   917 QQVLDEHSKL-----QNAQELMDHDHRTLQDKCD---------------------AYEKDKLLTK 955

Human  1399 LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1463
                  ..::.:....|||...|..:..                .|.|::..:|.||::..|::.
  Fly   956 ------HTLDCLQSASEELHRVKANLDR----------------ELKEQDQQLSELRERQREQEQ 998

Human  1464 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKE 1528
            :|.||.:..:         |:.|       .|..||         ||.|.|:..|:.||     :
  Fly   999 QLKDQAERCA---------KLKA-------QNSESE---------TQLQATISNLREQL-----D 1033

Human  1529 AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKT 1593
            ||::.||  .::|:|...|                            .|.|.:|..||...:...
  Fly  1034 AYKQTEQ--GIQEKLQATN----------------------------SSYTTQIATLEARWSAAN 1068

Human  1594 IEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1658
            .::|.|:|.    |....:|.::|  |::|    |:|::    |.:|.|.....||..::..:.|
  Fly  1069 SDVERLHEA----NDALQLEMEQL--KIKH----GQERE----EVKESIAQKNRQVVELQEAMAT 1119

Human  1659 KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1723
            :.::|          :|:::|      ||..||..|:..:.|. :....|||.:::.|.
  Fly  1120 RDRQL----------QEKIEA------SEKLAKFDEILIENEY-LNKHTKQLEAELAES------ 1161

Human  1724 GTESHLSELNTKLQEREREVHILEEKLK--SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1786
                  :||..||:..:.|:::|:||.:  :|:.::.||    :||...|..:|.::|..:..|:
  Fly  1162 ------AELKEKLKSLQCELYVLQEKAEQHAVQMAEKET----QSATATAEVSELKKAIEEQAVE 1216

Human  1787 KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH 1851
            .|.::                                            |||
  Fly  1217 LTRQK--------------------------------------------EHA------------- 1224

Human  1852 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1916
                        |.:..|.                    |.|||.|
  Fly  1225 ------------SFVTEQS--------------------DAVQKDL------------------- 1238

Human  1917 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHN 1981
             |..|:::|..::|...|:.|:.....:.||..:....|:|:....:.|..:: .|...::.:..
  Fly  1239 -LQAQQQLHDKQIELAMSRDEQALLQAEADGLRQEVICLKEHLSPSTDSDSLR-SLNERLQRELE 1301

Human  1982 DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN 2046
            ||:.|.||||                     ...|||:|                     ||:.|
  Fly  1302 DLKHKSAGAE---------------------SNMQQEIE---------------------ELQAN 1324

Human  2047 STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTA 2111
                      |.|:|::..||| |::..|                :..|||..:|.|:
  Fly  1325 ----------NQQMAERINELE-TLRAGI----------------QAQQLLASMAPKN------- 1355

Human  2112 KRYEEILDAREE-EMTAKVRDLQTQLEELQKK---YQQKLEQEENPGNDNVTIMELQTQLAQKTT 2172
              .:|...|.|: |:.:|::::..:::::..:   .:||.|        |..|:|.
  Fly  1356 --VQEAAAAGEKAELESKLKEIMNEVQDVTNRNLFLEQKCE--------NFLILEQ--------- 1401

Human  2173 LISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVL 2237
              |:.:||.|.            .|..:.:..|.|       ::.|::.  ....|||||||.::
  Fly  1402 --SNERLKLQN------------AKLSRQLDETLV-------SMQHSEA--VPANTEFEYLRNIM 1443

Human  2238 FEYMMGR-ETKTMAKVITTVLKFPDDQTQKILEREDAR 2274
            |:|:.|. ..:|:.|||:.||||...|.|..||:|..|
  Fly  1444 FQYLTGNTNNETLVKVISAVLKFSPQQAQVALEKEHQR 1481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GOLGA4	XP_005265126.1	SMC_prok_B	796..1720	CDD:274008	189/939 (20%)
		SMC_prok_B	<1501..2196	CDD:274008	130/700 (19%)
		Grip	2227..2270	CDD:197860	21/43 (49%)
Golgin245	NP_611787.2	Smc	286..1089	CDD:224117	254/1260 (20%)
		Phage_GPO	<306..421	CDD:301727	40/210 (19%)
		Smc	737..1442	CDD:224117	233/1221 (19%)
		MIT_CorA-like	<1244..>1333	CDD:294313	27/141 (19%)
		Grip	1433..1477	CDD:197860	21/43 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147623
Domainoid	1	1.000	288	1.000	Domainoid score	I1586
eggNOG	1	0.900	-	-		E1_28M43
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2833
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007308
OrthoInspector	1	1.000	-	-		oto91270
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19327
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5799
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.970