Protein Alignment GOLGA3 and mud

DIOPT Version :9

• Sequence 1: NP_001376612.1
• Gene: GOLGA3 / 2802
• HGNCID: 4426
• Length: 1498
• Species: Homo sapiens
• Sequence 2: NP_727769.3
• Gene: mud / 44839
• FlyBaseID: FBgn0002873
• Length: 2567
• Species: Drosophila melanogaster
• Alignment Length: 1754
• Identity: 356/1754 - (20%)
• Similarity: 666/1754 - (37%)
• Gaps: 495/1754 - (28%)

Human    81 SLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLC--------- 136
            ||.|.|:|....:|.    ....||:.:..:||   .||.|    |:|...:.:||
  Fly   412 SLSPNTTPENLASSV----IDKQLREKEHENAE---LKEKL----LNLNNSQRELCQALSSFLQK 465

Human   137 -STDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPR 200
             :.|...|:|           |....|          .|:..|.:::..:||:
  Fly   466 HNIDHEFPVE-----------WTSSSL----------LSTISAIESKFVNTLE------------ 497

Human   201 ASTLAMTKEYSFLRTSVPR---GPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGN 262
             .:..|.||.......|.:   ..|:.|:.|...|:|.                       .|..
  Fly   498 -KSTQMKKECDVQSVCVEKLLEKCKLLSVSLGCQPKEL-----------------------DGFE 538

Human   263 VPAPDSTKGSLKQNR------SSAASVVSEISLSPDTDDRLENTSLAGDSVSE----VDGNDSDS 317
            ...|::.:...:.:|      |.....|.:|: |.:.|..|:|..| .|..:|    :|..|...
  Fly   539 ATIPEAMESGFESSRECETILSCCHMKVVDIA-SKNNDLELDNERL-NDKCAELKSIIDRGDQHL 601

Human   318 SSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIP---------ADTLGQFPSIKDVLQAAAAEHQ 373
            :..:       ..::.|....:|.     |.||.         .:.|.|... |:...|:.|:|.
  Fly   602 ADIN-------LQLIEKEKQIKDV-----GAEIQELRKRNINLENMLSQIAD-KEASAASHAQHL 653

Human   374 DQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEG---QLEALSLEASQALKEK 435
            .|    .||:...:..:|.:..:..:||:.:...:.::.:...|.|   ||..|.:...:..|..
  Fly   654 KQ----CGELLRAKYEVCRNELIAKNAAQDELVRMMMVPDGETLNGRVRQLIDLEMMHDEHNKMY 714

Human   436 AELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWD-----LERAMTDLQNMLEAKN 495
            |::..||..||.| ...:..||....::..:..|....:...:|     .:|.:|.:..:|.::|
  Fly   715 AQMLKQLNELSAK-HDNMTHSHLDFVKRTEIELETKNAQIMAFDEHNNHFDRFLTRIFTLLRSRN 778

Human   496 ----ASLASSNNDLQV--AEEQYQRL-------MAKVEDMQRSM---------LSKDN------- 531
                .::.|:.|.|:.  .|::::.:       :...:|::|.:         |:|.|
  Fly   779 CPKSTTMGSATNFLESMHIEKRFENIEMLIEGQLLSADDLKRELDDLRSKNEELAKQNINGIIKR 843

Human   532 ---------TVHDLRQQMTALQSQL-----QQVQLERTTLTSKLKASQAEIS-----SLQSVRQW 577
                     ....::|.:|.|:.:.     :.||||.|  .||.:::..|::     :.|.::.:
  Fly   844 NKFITSLEVNTEKVKQYITDLEEEAFKRKQKVVQLENT--LSKEQSNAKEMAQRLDIAQQEIKDY 906

Human   578 YQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKL---------ENVSLSQQLTETQHRSMK 633
            :.:.:......|.|||.:...:...|.....:.|.||:         |:.||.::|||:|.:...
  Fly   907 HVEAIRFINTIRDRLQQDFNGVNTPQQLGTCMTEFLKMYDQMEVRYEESSSLVEKLTESQAKLEM 971

Human   634 EKGRIAAQLQGIEADM-----------------------------------------------LD 651
            :...:..:|:..:.:.                                               ||
  Fly   972 QVAELQVELENKDTNQHSGALIKQLNDTIQNLEKVNAKLSEDNTVSHTVHSKLNESLLKAQKELD 1036

Human   652 QEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
            ..|..::..||.   |.:|..:|.|.:..:.:|:...:..|.:::..|: ::..||....:||.:
  Fly  1037 LRAKIIENLEAS---ERNLSMKLCELKDLKNKLKSSDEKIAQIKETYEE-QIKALQAKCDMEAKK 1097

Human   717 QEHLDLMKQLTLTQEALQSREQSLD---ALQTHYDELQARLGELQGEAASREDTICLLQNEKIIL 778
            .|||:..:..:||    |.:|.:|:   .:.|..:||||:|.|.|....|::..:.:.:.|..::
  Fly  1098 NEHLERNQNQSLT----QLKEDALENCVLMSTKLEELQAKLQEGQQLVDSQKLELDMNRKELALV 1158

Human   779 EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELA-IKSG-------------QVEHLQQ 829
            ::|.:|.....::|.|.....::..:.....|||.|:||| :.|.             |.|..||
  Fly  1159 KSAYEAQTKLSDDLQRQKESGQQLVDNLKVELEKERKELAHVNSAIGAQTKLSDDLECQKESGQQ 1223

Human   830 ETAALKKQMQKIKEQFLQQKVMVEA-------YRRDATSKDQLISELKATRKRLDSELKELRQEL 887
            ....||.:::|.:::..|.|.::||       .:|:..|..||:..||.       ||.:.|:||
  Fly  1224 LVDNLKVELEKERKELAQVKSVIEAQTKLSDDLQREKESAQQLVDNLKV-------ELDKERKEL 1281

Human   888 MQVHG--------------EKRTAE-------AELSRLHREVAQVRQHMA-------DLEGHLQS 924
            .||:.              :|.:|:       .||.:..:|:|||.....       ||:...:|
  Fly  1282 AQVNSAFEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAQVNSAFEAQTKLSDDLQREKES 1346

Human   925 AQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ 989
            ||:..|.::..|..   :::::..|....||..|..::||::...|    :|.:..|..:|...:
  Fly  1347 AQQLVDNLKVELDK---ERKELAQVKSVIEAQTKLSDDLQRQKESA----QQLVDNLKVELDKER 1404

Human   990 KEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAV 1054
            ||: .|.|:...|...||..||.   .||:|.    ||.||...||......|..|      |.|
  Fly  1405 KEL-AKVKSVIEAQTKLSDDLQR---QKESAQ----QLEAQTKLSDDLQRQKESAQ------QLV 1455

Human  1055 SHSKTLLEKELQEVIAL---------TSQELEESREKVLELED----ELQESR----------GF 1096
            .:.|..|:||.:|:..:         .|.:|:..:|...:|.|    ||.:.|          |.
  Fly  1456 DNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKMELDKERKELAQVKSAIGA 1520

Human  1097 RKKIKRLEESNKK--------LALELEHEKGKLTGLGQSNAALREHNSI-----LETALAKREAD 1148
            :.|:....|..|:        |.:|||.|:.:   |.:.|:|......:     |:...|:||..
  Fly  1521 QTKLSDDLECQKESVQQLVDNLKVELEKERKE---LAKVNSAFEAQTKLSDDLKLQKEDAQREVF 1582

Human  1149 LVQLNLQVQAVLQRKEEEDR--QMKHLVQALQ---ASLEKEK----EKVNSLKE----------- 1193
            ||:..|    |.:::|.|.:  .::.:::.|:   ..:|:|:    |::|.|:.
  Fly  1583 LVKERL----VKEKREFEVKLATLEDIIETLEMRCTQMEEERATAYEQINKLENRCQEKDNVKSS 1643

Human  1194 --QVAAAKVEAGHNRRHFKAASLE--LSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQ---EI 1251
              ||...|||..|::...:.|:..  :.::.::|..|   |.||......|.....:|:|   ::
  Fly  1644 QLQVETFKVECLHHQLKSEMATHNSLVEDLNRKLAEK---VSKLDFVQSRLMTEIAEHNQVKDQL 1705

Human  1252 AQF----------------QAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWE-------V 1293
            ||.                .||..||:.:|.::..:|||.       .:|::|.:.|       :
  Fly  1706 AQITDIPKVVELQHRLEAETAEREEAQNKLAVVTGRLDEI-------TRELDNARLEHGAQILRM 1763

Human  1294 DQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELE------------------------- 1333
            ::..||:.:...:|....:..|..:|.|::||.....|||
  Fly  1764 EETAREVGNKNAELCELIEFYRNRVEALERLLLASNQELEELNSIQSNQAEGVRDLGDTYSAAEG 1828

Human  1334 ---MAQEDLSMTQK---DKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAK------------ 1380
               .:.:|....||   |..:||||..:.|:.:|...::.:..:|::.....|
  Fly  1829 RQTESDQDKERYQKLALDCKILQAKYRDAKDEIKRCEKKIKDQRLEMEGKLEKMKNKMRSLYTAE 1893

Human  1381 -TRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQR 1444
             ||.:.|.|..::..|:.:             |.|....|..:|..:.|::.:.:|.::   :..
  Fly  1894 VTRMKEKQERDAAKSASEL-------------EALTAQNAKYEEHTRKLSNQIVRLNEK---ILE 1942

Human  1445 QMEEHALTV----HESLSSWTPLEPATASPVPPGGHAGPRGD------PQRHSQSRASKEGPGE 1498
            |.::||:..    |..:...:..:|::.:.......:.|..|      |...|.:.|.::..||
  Fly  1943 QQKQHAIISTNLRHLQMQPISETKPSSTTLTVSSSSSAPNDDWQPFKRPNVPSSNLAMEDEEGE 2006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GOLGA3	NP_001376612.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118		10/36 (28%)
		Interaction with GOPC. /evidence=ECO:0000269|PubMed:15951434	121..141		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..195		4/28 (14%)
		Golgi-targeting domain	172..257		13/87 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..325		21/121 (17%)
		SMC_prok_B	<393..743	CDD:274008	83/464 (18%)
		Smc	630..1358	CDD:224117	206/943 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	789..809		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..993		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1376..1400		6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1440..1498		10/67 (15%)
mud	NP_727769.3	SMC_prok_B	319..1178	CDD:274008	162/863 (19%)
		SCP-1	853..1571	CDD:114219	170/758 (22%)
		Smc	1234..>1944	CDD:224117	168/770 (22%)
		DUF948	1392..1517	CDD:295114	37/138 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18902
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100