Protein Alignment GOLGA2 and GM130

DIOPT Version :10

• Sequence 1: NP_001353173.2
• Gene: GOLGA2 / 2801
• HGNCID: 4425
• Length: 1029
• Species: Homo sapiens
• Sequence 2: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Alignment Length: 1021
• Identity: 240/1021 - (23%)
• Similarity: 404/1021 - (39%)
• Gaps: 273/1021 - (26%)

Human    11 PAMSEETRQSKLAAAKKKLREYQQRNSPGVPTGAKKKKKIKNGSNPETTTSGGCHSPEDIQDILK 75
            |..:::.:..|||||:|||:|||||.|
  Fly     2 PDDTQDAKAQKLAAARKKLKEYQQRAS-------------------------------------- 28

Human    76 VLVSDLNRSNGVALPPLDKWKTPKDNAATLQPSDDTVLPGGVPSPGASLTSMAASQNHDADNVPN 140
                   .:||                                .|||.....|.:|:|
  Fly    29 -------NNNG--------------------------------QPGAEEPVAATTQSH------- 47

Human   141 LMDETKTFSSTESLRQLSQQLNGLVCESATCVNGEGPASSANLKDLESRYQQLAVALDSSYVTNK 205
                :.|.|.:.:|.:.|        :|...|||.|...:       ...:|.|:...:||..
  Fly    48 ----SSTVSISSNLSERS--------DSEINVNGGGAGGT-------QPPEQSALPTAASYFA-- 91

Human   206 QLNITIEKLKQQNQEITDQLEEEKKECHQKQGALREQLQVHIQTIGILVSEKAELQTALAHTQHA 270
                       ||:.             :..|.|.:...  :|.|.::::|||:|...|...:.|
  Fly    92 -----------QNES-------------EHNGGLADASS--LQAIQVIIAEKAQLNAELTKVRLA 130

Human   271 ARQKEGESEDLASRLQYSRRRVGELER-ALSAVSTQQKKADRYNKELTKERDALRLELYKNTQSN 334
            .|::|.|.|:|......::.|:.:|:: .....||.:::..:|.:        |:.:|.::....
  Fly   131 CRERELELEELRILKDQNQLRLEQLQQHCQDQQSTGEQQRQQYAQ--------LQAQLLQSQAQI 187

Human   335 EDLKQEKSELEEKLRVLVTEKAGMQLNLEELQKKLEMTELLLQQFSSRCEAPDANQ-----QLQQ 394
            :|.:...:|||.:|:.....:..:|..|.:...:|||.:|.|:|.|........|:     |.|.
  Fly   188 KDQQSHLNELEAQLKQSNQHQEELQQQLSQKSNELEMAQLKLRQLSDESSVTTDNRVESLVQTQY 252

Human   395 AMEERAQ-LEAHLGQVMESVRQLQMERDKYAENLKGESAMWRQRMQQMSEQVHTLREEKECSMSR 458
            ..|::.: |:|.:||:.:...|...:...|.::..||.|...:|..::||.:::|||.:...:..
  Fly   253 MYEQQIRDLQAMVGQLTQDKEQAAGQYQNYVQHQSGEIAKLNERNTELSEVLNSLRERERQLVEH 317

Human   459 VQELETSLAE---LRNQMAEPPPPEPPAGPSEVEQQLQAEAEHLRKELEGL-----AGQLQAQVQ 515
            |..||..:.:   |:.|..|....:|....:..::.|:.|...|::::|..     ..||:.:.|
  Fly   318 VGALERDIQKNISLQAQFKEASQVQPSKEETSEQKALKDELAVLKEQIENFEFERHEFQLKIKSQ 382

Human   516 DNEGLSRLNREQEERLLELERAAELWGEQAEARRQILETMQNDRTTISRALSQNRELKEQLAELQ 580
            |:: |...|...:|...:|||   |..||.: :.::|.||::|:...||||:||.|:|.||.|||
  Fly   383 DDQ-LQLKNSALDELEKQLER---LQAEQPD-QSKLLATMESDKVAASRALTQNVEMKNQLDELQ 442

Human   581 SGFVKLTNENMEITSALQSEQHVKRELGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGH 645
            ..||:|||:..|:...|.||:...||:.:....:::||...:|..:.|.:|...|..:
  Fly   443 QRFVQLTNDKAELVIRLDSEEFANREIRQNYNSMEQKLQANEERFKFKDEEMIRLSHE------- 500

Human   646 LQQYVAAYQQLTSEKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQ 710
                         ..|:...||:||.|| |:|:..||:.....|       ||::...|...:|:
  Fly   501 -------------NVELQRQQLMLQQQL-DRLRHYEAKAYHAGE-------ETEKENGADAPENE 544

Human   711 QLRAQLSLMAH-------PGEGDGLDREEEEDEEEEEEEAVAVPQPMP-SIPEDLESREAMVAFF 767
            ...|:...:.|       ....||...:.:.|...|.....|.....| ..|.|.....:
  Fly   545 AEEAKEVGLLHNHSHDHSHQHSDGHCHDNDHDHSHEHNHHNAGDHGHPHDHPHDHTHDHS----- 604

Human   768 NSAVASAEEEQARLRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAM 832
            :|.....:.:.....||....    |:.|..|.:|:                           |:
  Fly   605 HSHPHDHQHDHPHDHGQNHAH----RQAAETLPTAE---------------------------AV 638

Human   833 EKLQSRFMELMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEYISR 897
            |:|||||..|:.:.|||.|....|||..:||..||:||||||||||:||.:||:|..||...:..
  Fly   639 ERLQSRFTTLISQVADLTEEKHSLEHLVLQLQSETETIGEYIALYQTQRRMLKQREYEKAAQMRL 703

Human   898 LAQDKEEMKVKLLELQELVLRLVGDRNEWHGRFLAAAQNPADEPTSGAPAPQELGAANQQGDLCE 962
            |..::|:::.|:..|.:||:.|                        |...|.:...|.|
  Fly   704 LQAEREQLREKIEALNKLVVSL------------------------GVELPADAAQAKQ------ 738

Human   963 VSLAGSVEPAQGEAREGSPRDNPTAQQIM----QLLREMQNPRERP 1004
                    |......|.:|.:...:|||:    .::.|::...|:|
  Fly   739 --------PEAAAGSEHTPGEGENSQQIINKIQDIISEIKENTEQP 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GOLGA2	NP_001353173.2	SMC_prok_B	<180..472	CDD:274008	65/301 (22%)
		GOLGA2L5	408..935	CDD:464485	146/542 (27%)
		GM130_C	980..1025	CDD:465957	7/29 (24%)
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	76/313 (24%)
		GOLGA2L5	267..725	CDD:464485	145/526 (28%)