DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GNS and Sulf1

DIOPT Version :9

Sequence 1:	NP_002067.1	Gene:	GNS / 2799	HGNCID:	4422	Length:	552	Species:	Homo sapiens
Sequence 2:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	167/427 - (39%)
Similarity:	234/427 - (54%)	Gaps:	47/427 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    27 LLLVLGG------CLGVFGVAAGT---------------------RRPNVVLLLTDDQDEVLGGM 64
            |.|::||      .|.||....|:                     ||||::|:||||||..||.:
  Fly     7 LRLIIGGLILLLFVLNVFSKEQGSHSHKRSHSAKRFSRDSNSARERRPNIILILTDDQDVELGSL 71

Human    65 TPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEP 129
            ..:.:|..|:.:.|..|..||..:.:|||:|:|:|||.|.|||.|..|  ..||||..||...|.
  Fly    72 NFMPRTLRLLRDGGAEFRHAYTTTPMCCPARSSLLTGMYVHNHMVFTN--NDNCSSPQWQATHET 134

Human   130 NTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARK 194
            .::...| |..||:|.:.|||||:|..      .::|.||..|..|..|||||||::::||:..|
  Fly   135 RSYATYL-SNAGYRTGYFGKYLNKYNG------SYIPPGWREWGGLIMNSKYYNYSINLNGQKIK 192

Human   195 HGENYSVDYLTDVLANVSLDFL---DYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRN 256
            ||.:|:.||..|::||.|:.||   ..::..:|..:.::.||||.|..:||||...|.||.....
  Fly   193 HGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSFPAPHGPEDSAPQYSHLFFNVTTHHT 257

Human   257 KNFNIHGTN--KHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNT 319
            .::: |..|  |.|::|..: ||.....:|.:....||.|||.|||..||::...|:..|||:||
  Fly   258 PSYD-HAPNPDKQWILRVTE-PMQPVHKRFTNLLMTKRLQTLQSVDVAVERVYNELKELGELDNT 320

Human   320 YIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGY 384
            ||.||||:|||.|||.|...|...:|||::||.|:|||||:.::....:|.|:||.||.||:.|.
  Fly   321 YIVYTSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQASKVVNEIVLNVDLAPTFLDMGGV 385

Human   385 DLNKTQMDGMSLLPILRGASNL---TWRSDVLVEYQG 418
            . ....|||.|:||:|...:..   .|....|:|..|
  Fly   386 P-TPQHMDGRSILPLLLSRNRAVRDNWPDSFLIESSG 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNS	NP_002067.1	G6S	46..495	CDD:293766	158/381 (41%)
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	152/358 (42%)
		G6S	53..408	CDD:293766	154/366 (42%)
		DUF3740	640..790	CDD:289325
		ALP_like	<940..989	CDD:304875
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	1	1.000	-	-		FOG0001009
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820