DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GNB1 and Gbeta5

DIOPT Version :9

Sequence 1:NP_001269468.1 Gene:GNB1 / 2782 HGNCID:4396 Length:340 Species:Homo sapiens
Sequence 2:NP_572452.1 Gene:Gbeta5 / 31744 FlyBaseID:FBgn0030011 Length:358 Species:Drosophila melanogaster


Alignment Length:340 Identity:164/340 - (48%)
Similarity:244/340 - (71%) Gaps:3/340 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     3 ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67
            ::..|.:|||.||.::.:.|:...|..||.|...::.:..:.::.|:.|:||.||:....|..|.
  Fly    18 KMASLVREAENLKTKLEEERQKLNDVNLSNIAERLEQIAYVNIKPRKVLKGHQAKVLCTDWSPDK 82

Human    68 RLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGN 132
            |.::|:||||:|||||::||||.||:.:.::|:|.||||||||:||||||||..::|.:.:.|..
  Fly    83 RHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPITSDEEM 147

Human   133 VRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDT 196
            ....|.:..||.|:|||.:.: |.||:|.|||:||||||:|:||...:|.||:||||::.|||:.
  Fly   148 AAKKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNE 212

Human   197 --RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ 259
              ..||||:||..|.:||:|.|...|:|.||:||:|::.|.|.|:|.||||||::|||:|:|||:
  Fly   213 TGNTFVSGSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADR 277

Human   260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDG 324
            |:..::.::||.|:.||.||.|||||.|||:|:..|:||.||::|..:|.||:|:|||:.|:.||
  Fly   278 EVAVFAKESIIFGVNSVDFSVSGRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVSPDG 342

Human   325 MAVATGSWDSFLKIW 339
            .|::|||||..:::|
  Fly   343 TALSTGSWDYTIRVW 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GNB1NP_001269468.1 WD40 48..340 CDD:238121 153/295 (52%)
WD 1 53..83 15/29 (52%)
WD40 repeat 58..95 CDD:293791 19/36 (53%)
WD 2 95..125 18/29 (62%)
WD40 repeat 101..141 CDD:293791 20/39 (51%)
WD 3 141..170 17/29 (59%)
WD40 repeat 146..181 CDD:293791 19/35 (54%)
WD 4 182..212 16/31 (52%)
WD40 repeat 188..223 CDD:293791 16/36 (44%)
WD 5 224..254 18/29 (62%)
WD40 repeat 229..265 CDD:293791 19/35 (54%)
WD 6 268..298 17/29 (59%)
WD40 repeat 273..309 CDD:293791 19/35 (54%)
WD 7 310..340 16/30 (53%)
WD40 repeat 315..339 CDD:293791 12/23 (52%)
Gbeta5NP_572452.1 WD40 62..358 CDD:238121 153/296 (52%)
WD40 repeat 73..110 CDD:293791 19/36 (53%)
WD40 repeat 116..156 CDD:293791 20/39 (51%)
WD40 repeat 161..197 CDD:293791 19/35 (54%)
WD40 repeat 204..241 CDD:293791 16/36 (44%)
WD40 repeat 247..283 CDD:293791 19/35 (54%)
WD40 repeat 291..327 CDD:293791 19/35 (54%)
WD40 repeat 333..357 CDD:293791 12/23 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0286
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D313727at33208
OrthoFinder 1 1.000 - - FOG0000271
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X182
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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