DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GNAZ and Galphaq

DIOPT Version :9

Sequence 1:	NP_002064.1	Gene:	GNAZ / 2781	HGNCID:	4395	Length:	355	Species:	Homo sapiens
Sequence 2:	NP_725192.2	Gene:	Galphaq / 36384	FlyBaseID:	FBgn0004435	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	174/408 - (42%)
Similarity:	221/408 - (54%)	Gaps:	67/408 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGGFNLEA 65
            |.|..|.|.||..|.::.|::.||.:.:..|||:|||||||..|||||.:|||:|||..|::.|.
  Fly     1 MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 65

Human    66 CKEYKPLIIYNAIDSLTRIIRALAALRIDFHNPDRA----------YDAVQLFALTGPAESKGEI 120
            .:.|..|:..|...::..:|:|:..|:|.:...:.:          |:.|..|
  Fly    66 KRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTF------------ 118

Human   121 TPELLGVMRRLWADPGAQACFSRSSEYHLEDNAAYYLNDLERIA--------------------- 164
            ....|..::.||.|.|.|.|:.|..||.|.|:|.|||.||:|:|
  Fly   119 EDPYLNAIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGI 183

Human   165 ----------------------AADYIPTVEDILRSRDMTTGIVENKFTFKELTFKMVDVGGQRS 207
                                  .|||:||.:||||:|..||||:|..|....:.|:|||||||||
  Fly   184 IEYPFDLEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRS 248

Human   208 ERKKWIHCFEGVTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNWFINTSLILFLNKK 272
            ||:|||||||.||:|||.|.||.||..|:|.:..:||.||..||.:|....||.|:|:|||||||
  Fly   249 ERRKWIHCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKK 313

Human   273 DLLAEKIRRIPLTICFPEYKG-QNTYEEAAVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQFV 336
            |||.|||....|...||||.| |.....|..:|.|.|.|||.:.| |.|||||||||||.||:.|
  Fly   314 DLLEEKIMYSHLVDYFPEYDGPQRDAITAREFILRMFVDLNPDSE-KIIYSHFTCATDTENIKLV 377

Human   337 FDAVTDVIIQNNLKYIGL 354
            |.||.|.|:||.||...|
  Fly   378 FCAVKDTIMQNALKEFNL 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNAZ	NP_002064.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		10/24 (42%)
		G-alpha	34..349	CDD:206639	158/368 (43%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		4/4 (100%)
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	158/368 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R507
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850