DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GNAO1 and GPA1

DIOPT Version :9

Sequence 1:	NP_066268.1	Gene:	GNAO1 / 2775	HGNCID:	4389	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_011868.1	Gene:	GPA1 / 856394	SGDID:	S000001047	Length:	472	Species:	Saccharomyces cerevisiae

Alignment Length:	474	Identity:	168/474 - (35%)
Similarity:	243/474 - (51%)	Gaps:	124/474 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCTLSA-----EERAALERSKA---IEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIH 57
            ||||:|.     |....|:..:|   ||::|:.:......::||||||||||||||::||:|::|
Yeast     1 MGCTVSTQTIGDESDPFLQNKRANDVIEQSLQLEKQRDKNEIKLLLLGAGESGKSTVLKQLKLLH 65

Human    58 EDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIE---------------------------- 94
            :.|||.::..||..|::::.|||:..::.....|||:
Yeast    66 QGGFSHQERLQYAQVIWADAIQSMKILIIQARKLGIQLDCDDPINNKDLFACKRILLKAKALDYI 130

Human    95 ---------------------YGDKER--------------------KADAKMVCDVVSRMEDTE 118
                                 |..:.|                    |:|.....:.|::.||.:
Yeast   131 NASVAGGSDFLNDYVLKYSERYETRRRVQSTGRAKAAFDEDGNISNVKSDTDRDAETVTQNEDAD 195

Human   119 PFSA----------------------------------------ELLSAMMRLW-GDSGIQECFN 142
            ..::                                        ::..|:.:|| .|.||::||.
Yeast   196 RNNSSRINLQDICKDLNQEGDDQMFVRKTSREIQGQNRRNLIHEDIAKAIKQLWNNDKGIKQCFA 260

Human   143 RSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRS 207
            ||.|:||..||.||.|::::..:.:|..|::|||:.|:|||||.||.|...:..|::.|.|||||
Yeast   261 RSNEFQLEGSAAYYFDNIEKFASPNYVCTDEDILKGRIKTTGITETEFNIGSSKFKVLDAGGQRS 325

Human   208 ERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKK 272
            ||||||||||.:||::|.:|:|.|||:|.|||..||||||:||||::.|:|:|.||..||||||.
Yeast   326 ERKKWIHCFEGITAVLFVLAMSEYDQMLFEDERVNRMHESIMLFDTLLNSKWFKDTPFILFLNKI 390

Human   273 DLFGEKIKKSPLTICFPEYTGPNTYEDAAA---YIQAQFESKNRSPNKEIYCHMTCATDTNNIQV 334
            |||.||:|..|:...||:|.|  ...||.|   |.:..|.|.|:: ||.||...||||||..::.
Yeast   391 DLFEEKVKSMPIRKYFPDYQG--RVGDAEAGLKYFEKIFLSLNKT-NKPIYVKRTCATDTQTMKF 452

Human   335 VFDAVTDIIIANNLRGCGL 353
            |..||||:||..||:..|:
Yeast   453 VLSAVTDLIIQQNLKKIGI 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	154/426 (36%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		4/8 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
GPA1	NP_011868.1	G-alpha	42..466	CDD:206639	154/426 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	311	1.000	Domainoid score	I221
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I513
Isobase	1	0.950	-	0	Normalized mean entropy	S412
OMA	1	1.010	-	-		QHG54330
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	1	1.100	-	-	LDO	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.850