DRSC/TRiP Functional Genomics Resources

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Protein Alignment GNAO1 and gnao1a

DIOPT Version :9

Sequence 1:NP_066268.1 Gene:GNAO1 / 2775 HGNCID:4389 Length:354 Species:Homo sapiens
Sequence 2:NP_957081.1 Gene:gnao1a / 393760 ZFINID:ZDB-GENE-040426-1757 Length:354 Species:Danio rerio


Alignment Length:354 Identity:339/354 - (95%)
Similarity:350/354 - (98%) Gaps:0/354 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGED 65
            |||||||||||||:||||||||||||||:||||||||||||||||||||||||||||||||||:|
Zfish     1 MGCTLSAEERAALDRSKAIEKNLKEDGITAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGDD 65

Human    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMR 130
            |||||||||||||||||||||||||||:||||||||||||||||||||||||||:|.||||||:|
Zfish    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGLEYGDKERKADAKMVCDVVSRMEDTEPYSPELLSAMIR 130

Human   131 LWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNL 195
            ||.||||||||:|:|||||||||:|||||||||||||||||||||||||||||||||||||||||
Zfish   131 LWSDSGIQECFSRAREYQLNDSAQYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNL 195

Human   196 HFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFF 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   196 HFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFF 260

Human   261 IDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTC 325
            |||||||||||||||.||||||||:||||||||||||:|||||||||||||||||||||||||||
Zfish   261 IDTSIILFLNKKDLFAEKIKKSPLSICFPEYTGPNTYDDAAAYIQAQFESKNRSPNKEIYCHMTC 325

Human   326 ATDTNNIQVVFDAVTDIIIANNLRGCGLY 354
            ||||.||||||||||||||||||||||||
Zfish   326 ATDTGNIQVVFDAVTDIIIANNLRGCGLY 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GNAO1NP_066268.1 G-alpha 34..348 CDD:206639 300/313 (96%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 35..48 12/12 (100%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 174..182 7/7 (100%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 197..206 8/8 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 266..273 6/6 (100%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 324..329 4/4 (100%)
gnao1aNP_957081.1 G-alpha 34..348 CDD:206639 300/313 (96%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C194327034
Domainoid 1 1.000 606 1.000 Domainoid score I1673
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H39203
Inparanoid 1 1.050 652 1.000 Inparanoid score I4751
NCBI 1 1.000 - -
OMA 1 1.010 - - QHG54330
OrthoDB 1 1.010 - - D245255at7742
OrthoFinder 1 1.000 - - FOG0000052
OrthoInspector 1 1.000 - - oto48222
orthoMCL 1 0.900 - - OOG6_100285
Panther 1 1.100 - - LDO PTHR10218
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R506
SonicParanoid 1 1.000 - - X53
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 1 1.500 - -
1818.400

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