Protein Alignment GNAO1 and Galphas

DIOPT Version :10

• Sequence 1: NP_066268.1
• Gene: GNAO1 / 2775
• HGNCID: 4389
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Alignment Length: 382
• Identity: 165/382 - (43%)
• Similarity: 209/382 - (54%)
• Gaps: 35/382 - (9%)

Human     1 MGC----------TLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKI 55
            |||          ..|.:.::...||.||.:.|::|........:||||||||||||||||||:|
  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65

Human    56 IHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLG--IEYGDKERKADAKMVCDVVSRMEDTE 118
            :|.||||..:.||....:..|...::..|..||.||.  :....||.:...:.:.|..|..:...
  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNY 130

Human   119 PFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTT 183
            |  .|.......||.|.|:.:.:.||.||||.|.|||:||.:..|...:|.|.||||||.||.|:
  Fly   131 P--PEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTS 193

Human   184 GIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESL 248
            ||.||.|....::|.:|||||||.||:|||.||.|||||||..|.|.|:.||.||.|.||:.|||
  Fly   194 GIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESL 258

Human   249 MLFDSICNNKFFIDTSIILFLNKKDLFGEKIK--KSPLTICFPEY--------TGPNTYED---- 299
            .||.||.||::....||||||||:||..||||  ||.|:..|.|:        ||....|.
  Fly   259 DLFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDP 323

Human   300 ----AAAYIQAQF-ESKNRSPNKEIYC--HMTCATDTNNIQVVFDAVTDIIIANNLR 349
                |..:|:.:| .....|.:.:.||  |.|||.||.||:.||:...|||...:||
  Fly   324 EVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLR 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	153/336 (46%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		3/4 (75%)
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	153/336 (46%)