DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GNAO1 and Galphaq

DIOPT Version :9

Sequence 1:	NP_066268.1	Gene:	GNAO1 / 2775	HGNCID:	4389	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_725192.2	Gene:	Galphaq / 36384	FlyBaseID:	FBgn0004435	Length:	396	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	183/399 - (45%)
Similarity:	230/399 - (57%)	Gaps:	58/399 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGED 65
            |.|.||.|.:.....::.|||.|:.|...|.:::||||||.|||||||.:|||:|||..|:|.||
  Fly     1 MECCLSEEAKEQKRINQEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 65

Human    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDV----VSRMEDTEPFSAELLS 126
            .:.|..:|:.|...::.::::|||.|.|.||..|....|.:|..:    |:..||  |:    |:
  Fly    66 KRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFED--PY----LN 124

Human   127 AMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIG--------------------------- 164
            |:..||.|:|||||::|.|||||.|||||||..|||:.
  Fly   125 AIKTLWDDAGIQECYDRRREYQLTDSAKYYLKDLDRVAQPAYLPTEQDILRVRVPTTGIIEYPFD 189

Human   165 ----------------AADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWI 213
                            .|||.||||||||.||.||||:|..|....:.||:.|||||||||:|||
  Fly   190 LEEIRFSYLSDLARIEQADYLPTEQDILRARVPTTGILEYPFDLDGIVFRMVDVGGQRSERRKWI 254

Human   214 HCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEK 278
            ||||:||:|||.||||.|||:|.|.:..|||.||..||.:|....:|.::|:|||||||||..||
  Fly   255 HCFENVTSIIFLVALSEYDQILFESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEK 319

Human   279 IKKSPLTICFPEYTGPNTYEDAAA---YIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVT 340
            |..|.|...||||.||.  .||..   :|...|...|....|.||.|.||||||.||::||.||.
  Fly   320 IMYSHLVDYFPEYDGPQ--RDAITAREFILRMFVDLNPDSEKIIYSHFTCATDTENIKLVFCAVK 382

Human   341 DIIIANNLR 349
            |.|:.|.|:
  Fly   383 DTIMQNALK 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	171/363 (47%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
Galphaq	NP_725192.2	G-alpha	34..390	CDD:206639	171/363 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820