DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GNAO1 and Galphao

DIOPT Version :9

Sequence 1:	NP_066268.1	Gene:	GNAO1 / 2775	HGNCID:	4389	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	291/354 - (82%)
Similarity:	318/354 - (89%)	Gaps:	0/354 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGED 65
            |||..|||||||..||:.||:|||||||.||||:||||||||||||||||||||||||.||:.||
  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65

Human    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMR 130
            .|||:|||||||||||.||:|||.||.|:|.:.||::|||||.||..||.||||||.|||:||.|
  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKR 130

Human   131 LWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNL 195
            ||.|:|:||||:||.||||||||||:||.|||:||.|||||||||||||||||||||.||:||||
  Fly   131 LWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNL 195

Human   196 HFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFF 260
            :|:|||||||||||||||||||||||||||||:|.||||||||||||||.|||.|||||||||:|
  Fly   196 NFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWF 260

Human   261 IDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTC 325
            .||||||||||||||.|||:|||||||||||||...|.:||||||||||:||:|.:|||||||||
  Fly   261 TDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNKSTSKEIYCHMTC 325

Human   326 ATDTNNIQVVFDAVTDIIIANNLRGCGLY 354
            ||||||||.|||||||:||||||||||||
  Fly   326 ATDTNNIQFVFDAVTDVIIANNLRGCGLY 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	258/313 (82%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		7/7 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	258/313 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144711
Domainoid	1	1.000	555	1.000	Domainoid score	I243
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39203
Inparanoid	1	1.050	596	1.000	Inparanoid score	I969
Isobase	1	0.950	-	0	Normalized mean entropy	S412
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	1	1.000	-	-		oto88944
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	1	1.100	-	-	LDO	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750