Protein Alignment GNAO1 and cta

DIOPT Version :10

• Sequence 1: NP_066268.1
• Gene: GNAO1 / 2775
• HGNCID: 4389
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001036421.1
• Gene: cta / 3355131
• FlyBaseID: FBgn0000384
• Length: 457
• Species: Drosophila melanogaster
• Alignment Length: 353
• Identity: 152/353 - (43%)
• Similarity: 207/353 - (58%)
• Gaps: 20/353 - (5%)

Human     8 EERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPV 72
            ||.....:||.|:|.|:::..:..:.|||||||||||||||.:|||:|||...|..|.:.:|:.|
  Fly   107 EELEQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRIIHGVNFDYELLLEYQSV 171

Human    73 VYSNTIQSLAAIVRAMDTLGIEYGDKERKADA----KMVC---DVVSRMEDTEPFSAELLSAMMR 130
            :|.|.|:.:..::.|.:.|.|.:|...|:.||    .|.|   ||...||...|.|        |
  Fly   172 IYQNVIRGMQVLLDAREKLNIAWGSDGREQDAYDAKLMECNSLDVPKFMEYAPPIS--------R 228

Human   131 LWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNL 195
            ||.|.||:..|.|.||:|::||..|:||.:.|:...||.||.:|||..|..|.|:.|.....:|:
  Fly   229 LWQDRGIRRAFERRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATKGVYEFCVKVQNI 293

Human   196 HFRLFDVGGQRSERKKWIHCFE-DVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKF 259
            .|...||||||::|:||..||: .||:|||.|:.|.:||||.||..|||:.||..:||:|.||..
  Fly   294 PFVFVDVGGQRTQRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEESKNIFDTIVNNAT 358

Human   260 FIDTSIILFLNKKDLFGEKI--KKSPLTICFPEYTG-PNTYEDAAAYIQAQFESKNRSPN-KEIY 320
            |...||||||||.||..:|:  .::.:...:|.:.| |::..|...:|...|.|..||.: ..||
  Fly   359 FKGISIILFLNKTDLLEQKVCNPETDIRWYYPHFNGNPHSVLDVQNFILQMFMSVRRSSSISRIY 423

Human   321 CHMTCATDTNNIQVVFDAVTDIIIANNL 348
            .|.|.|.||.||.|||::|.|.|:..||
  Fly   424 HHFTTAIDTRNINVVFNSVKDTILQRNL 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	143/325 (44%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		4/7 (57%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		5/8 (63%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		2/4 (50%)
cta	NP_001036421.1	G_alpha	112..455	CDD:214595	150/348 (43%)