Protein Alignment GNAO1 and CG30054

DIOPT Version :10

• Sequence 1: NP_066268.1
• Gene: GNAO1 / 2775
• HGNCID: 4389
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001036538.3
• Gene: CG30054 / 246420
• FlyBaseID: FBgn0050054
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 163/361 - (45%)
• Similarity: 217/361 - (60%)
• Gaps: 15/361 - (4%)

Human     1 MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGED 65
            |.|..|.|.......::.|:|.|:.:...:.:::|||||||.||||||.:|||:|||..|:|.||
  Fly     1 MHCCSSTEAMEKRRINEEIDKQLRLEKKRSKRELKLLLLGACESGKSTFIKQMRIIHGSGYSDED 65

Human    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDV----VSRMEDTEPFSAELLS 126
            .:.|..:|:.|...::.::::|||.|.|.||..|....|.:|..:    |:..||  |:    |:
  Fly    66 KRGYIKLVFQNIFMAMQSMIKAMDMLKISYGQGEHSELADLVMSIDYETVTTFED--PY----LN 124

Human   127 AMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFT 191
            |:..||.|:|||||::|.|||||.||.:|:|..:.||..|||.||.|||||.|..|..|....|.
  Fly   125 AIKTLWHDAGIQECYDRRREYQLTDSTEYFLGDIGRIEQADYLPTNQDILRAREPTFNITVYPFE 189

Human   192 FKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICN 256
            .......:.||.|||:||:||||.|.:||:|||..|||.|||.:.|.|..||:.||..||.:|..
  Fly   190 LDGYVLSMVDVAGQRTERRKWIHFFSNVTSIIFLAALSEYDQFMMESENDNRLEESKALFHTIIT 254

Human   257 NKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAA---YIQAQFESKNRSPNKE 318
            .::|.:.||||||||.|:..|||..|.|...||||.||.  :||.|   |:...|:|.:....|:
  Fly   255 FEWFKNASIILFLNKMDVLEEKIMYSHLVDYFPEYDGPK--QDAYAAREYVLRMFQSISLDTYKK 317

Human   319 IYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY 354
            ||.|.||||||.||:.||.||.|.|:..||:...|:
  Fly   318 IYSHFTCATDTENIKFVFAAVKDTILQCNLKESNLF 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	153/320 (48%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		3/8 (38%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
CG30054	NP_001036538.3	G-alpha	34..347	CDD:206639	153/320 (48%)