Protein Alignment GNAO1 and goa-1

DIOPT Version :9

• Sequence 1: NP_066268.1
• Gene: GNAO1 / 2775
• HGNCID: 4389
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_492108.1
• Gene: goa-1 / 172505
• WormBaseID: WBGene00001648
• Length: 354
• Species: Caenorhabditis elegans
• Alignment Length: 354
• Identity: 291/354 - (82%)
• Similarity: 322/354 - (90%)
• Gaps: 0/354 - (0%)

Human     1 MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGED 65
            ||||:|.|||||||||:.|||||||||:.||||:||||||||||||||||||||||||.||:.||
 Worm     1 MGCTMSQEERAALERSRMIEKNLKEDGMQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65

Human    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMR 130
            .|||||||||||:|||.||:|||..||:.:|..:|:.|||:|.|||:|||||||||.||||:|.|
 Worm    66 YKQYKPVVYSNTVQSLVAILRAMSNLGVSFGSADREVDAKLVMDVVARMEDTEPFSEELLSSMKR 130

Human   131 LWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNL 195
            ||||:|:|:||:||.||||||||||:||.|:|:|.|.||||||||||||||||||||.|||||||
 Worm   131 LWGDAGVQDCFSRSNEYQLNDSAKYFLDDLERLGEAIYQPTEQDILRTRVKTTGIVEVHFTFKNL 195

Human   196 HFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFF 260
            :|:|||||||||||||||||||||||||||||:|.||||||||||||||||||.|||||||||:|
 Worm   196 NFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMHESLKLFDSICNNKWF 260

Human   261 IDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTC 325
            .||||||||||||||.|||||||||||||||:|...|.:|:||||||||:||:|.||||||||||
 Worm   261 TDTSIILFLNKKDLFEEKIKKSPLTICFPEYSGRQDYHEASAYIQAQFEAKNKSANKEIYCHMTC 325

Human   326 ATDTNNIQVVFDAVTDIIIANNLRGCGLY 354
            ||||.|||.|||||||:||||||||||||
 Worm   326 ATDTTNIQFVFDAVTDVIIANNLRGCGLY 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	256/313 (82%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		7/7 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
goa-1	NP_492108.1	G_alpha	14..352	CDD:214595	276/337 (82%)
		G-alpha	34..348	CDD:206639	256/313 (82%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161452002
Domainoid	1	1.000	556	1.000	Domainoid score	I137
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39203
Inparanoid	1	1.050	604	1.000	Inparanoid score	I556
Isobase	1	0.950	-	0	Normalized mean entropy	S412
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	1	1.000	-	-		oto23204
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	1	1.100	-	-	LDO	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790