Protein Alignment GNAO1 and Gnao1

DIOPT Version :9

• Sequence 1: NP_066268.1
• Gene: GNAO1 / 2775
• HGNCID: 4389
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001106855.1
• Gene: Gnao1 / 14681
• MGIID: 95775
• Length: 354
• Species: Mus musculus
• Alignment Length: 354
• Identity: 327/354 - (92%)
• Similarity: 341/354 - (96%)
• Gaps: 0/354 - (0%)

Human     1 MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGED 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGED 65

Human    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMR 130
            |||||||||||||||||||||||||||:||||||||.|:||||||||||||||||||||||||||
Mouse    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKTDSKMVCDVVSRMEDTEPFSAELLSAMMR 130

Human   131 LWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNL 195
            |||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
Mouse   131 LWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTTGIVETHFTFKNL 195

Human   196 HFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFF 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||:|
Mouse   196 HFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLKLFDSICNNKWF 260

Human   261 IDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTC 325
            .||||||||||||:|.||||||||||||||||||:.:.:|.|:||.|:||||:|.:||:|.|:||
Mouse   261 TDTSIILFLNKKDIFEEKIKKSPLTICFPEYTGPSAFTEAVAHIQGQYESKNKSAHKEVYSHVTC 325

Human   326 ATDTNNIQVVFDAVTDIIIANNLRGCGLY 354
            ||||||||.|||||||:|||.||||||||
Mouse   326 ATDTNNIQFVFDAVTDVIIAKNLRGCGLY 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNAO1	NP_066268.1	G-alpha	34..348	CDD:206639	286/313 (91%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		7/7 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		8/8 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
Gnao1	NP_001106855.1	G_alpha	14..352	CDD:214595	310/337 (92%)
		G-alpha	34..348	CDD:206639	286/313 (91%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83954235
Domainoid	1	1.000	652	1.000	Domainoid score	I4365
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39203
Inparanoid	1	1.050	702	1.000	Inparanoid score	I9198
Isobase	1	0.950	-	0	Normalized mean entropy	S412
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	1	1.000	-	-		oto119504
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	1	1.100	-	-	LDO	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.350