Protein Alignment GNAI3 and Galphao

DIOPT Version :10

• Sequence 1: NP_006487.1
• Gene: GNAI3 / 2773
• HGNCID: 4387
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Alignment Length: 355
• Identity: 246/355 - (69%)
• Similarity: 290/355 - (81%)
• Gaps: 2/355 - (0%)

Human     1 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDE 65
            |||..|||::||..||::|:|||:|||.:|||::||||||||||||||||||||||||.|::.::
  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65

Human    66 CKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLF-VLAGSAEEGVMTPELAGVIKR 129
            .|||:.|||||||||::||:|||..|.|.:....|..||:.:| |.....:....:.||...:||
  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKR 130

Human   130 LWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFKDL 194
            ||:|.|||.|||||.||||||||.|:|:||||:...:|.||:||:||||||||||||.||:||:|
  Fly   131 LWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNL 195

Human   195 YFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWF 259
            .||:||||||||||||||||||.|||||||||:|:||.||.|||..|||.||:||||||||||||
  Fly   196 NFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWF 260

Human   260 TETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFT 324
            |:|||||||||||||||||::||||||:|||||...|.|||||||.|||..| :..:||||.|.|
  Fly   261 TDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKN-KSTSKEIYCHMT 324

Human   325 CATDTKNVQFVFDAVTDVIIKNNLKECGLY 354
            |||||.|:||||||||||||.|||:.||||
  Fly   325 CATDTNNIQFVFDAVTDVIIANNLRGCGLY 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNAI3	NP_006487.1	G-alpha	34..348	CDD:206639	220/314 (70%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	173..181		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	196..205		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	265..272		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	220/314 (70%)