DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GNAI2 and Galphao

DIOPT Version :9

Sequence 1:	NP_002061.1	Gene:	GNAI2 / 2771	HGNCID:	4385	Length:	355	Species:	Homo sapiens
Sequence 2:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster

Alignment Length:	355	Identity:	241/355 - (67%)
Similarity:	291/355 - (81%)	Gaps:	1/355 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEE 65
            |||..|||::|||.||::|::||:|||.:||:::||||||||||||||||||||||||.|::.|:
  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65

Human    66 CRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRR 130
            .:|||.|||||||||::||::||..|.|.:::..|..||:.:|.:.....:.....::|...::|
  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKR 130

Human   131 LWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDL 195
            ||.|.|||.||.||.||||||||.|:|:||:|:...||.||:||:||||||||||||.||:||:|
  Fly   131 LWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNL 195

Human   196 HFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWF 260
            :||:||||||||||||||||||.|||||||||:|.||.||.|||..|||.||:||||||||||||
  Fly   196 NFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWF 260

Human   261 TDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFT 325
            |||||||||||||||||||..||||||||||||..:|.|||:|||::||..|| ..:||||.|.|
  Fly   261 TDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNK-STSKEIYCHMT 324

Human   326 CATDTKNVQFVFDAVTDVIIKNNLKDCGLF 355
            |||||.|:||||||||||||.|||:.|||:
  Fly   325 CATDTNNIQFVFDAVTDVIIANNLRGCGLY 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNAI2	NP_002061.1	G-alpha	34..349	CDD:206639	217/314 (69%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		4/4 (100%)
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	217/314 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760