Protein Alignment GNAI1 and Galphao

DIOPT Version :9

• Sequence 1: NP_002060.4
• Gene: GNAI1 / 2770
• HGNCID: 4384
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Alignment Length: 356
• Identity: 247/356 - (69%)
• Similarity: 295/356 - (82%)
• Gaps: 4/356 - (1%)

Human     1 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEE 65
            |||..|||::||..||::|:|||:|||.:||:::||||||||||||||||||||||||:|::.|:
  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65

Human    66 CKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAE--EGFMTAELAGVIK 128
            .|||:.|||||||||::||:|||..|.|.:.::.|..||:.:|.:.....  |.| :.||...:|
  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPF-SEELLAAMK 129

Human   129 RLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKD 193
            |||:|:|||.||:||.||||||||.|:|:||||:...:|.||:||:||||||||||||.||:||:
  Fly   130 RLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKN 194

Human   194 LHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKW 258
            |:||:||||||||||||||||||.|||||||||:|:||.||.|||..|||.||:|||||||||||
  Fly   195 LNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKW 259

Human   259 FTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHF 323
            ||||||||||||||||||||:|||||||:|||.|...|.|||||||.|||..|| ..:||||.|.
  Fly   260 FTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNK-STSKEIYCHM 323

Human   324 TCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 354
            ||||||.|:||||||||||||.|||:.|||:
  Fly   324 TCATDTNNIQFVFDAVTDVIIANNLRGCGLY 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GNAI1	NP_002060.4	G-alpha	34..348	CDD:206639	223/315 (71%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	173..181		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	196..205		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	265..272		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	223/315 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860