DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam4 and Igsf9

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	NP_001139272.1	Gene:	Igsf9 / 93842	MGIID:	2135283	Length:	1179	Species:	Mus musculus

Alignment Length:	872	Identity:	197/872 - (22%)
Similarity:	321/872 - (36%)	Gaps:	235/872 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 VSLTVTAPLTAHLQPQVQTV--DVDKDAQFQCIV---SGH-PVHDVNWLHDG--KPILRD----- 373
            :||.::.......:|:|.:|  ...:.|...|.:   :|| |:|.:.||..|  .||...
Mouse    10 LSLIISQGADGRRKPEVVSVVGRAGESAVLGCDLLPPAGHPPLHVIEWLRFGFLLPIFIQFGLYS 74

  Fly   374 --------NRVEILTDPPRLIIKKVQKEDPGMYQC-------------FVSNEWEQIQSTAELQL 417
                    .||.:.|. ..|.|:.::.||.|.|:|             |.:..|..:...:..|.
Mouse    75 PRIDPDYVGRVRLQTG-ASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQF 138

  Fly   418 GDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSRFLVGQYVTIHDDVIS 482
            .:..|.:|      .::....|:|:|||.|:|.|..||...|..:....    || |.:.:..:.
Mouse   139 QETPPLVL------EVKELEAVTLRCVARGSPQPYVTWKFRGQDLGKGQ----GQ-VQVQNGTLW 192

  Fly   483 HVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPKITGISGS-DLIVKCPVAGYP 546
               |..|:....|:|||.|.::.|.::|:.::.:.|.|.|...|..:.::.| |:.:.|....||
Mouse   193 ---IRRVERGSAGDYTCQASSSEGSITHATQLLVLGPPVIVVPPSNSTVNSSQDVSLACRAEAYP 254

  Fly   547 IDKIH-WERDG-QTLPINR---RQRAYNNGTLIIEQLQRLEDAGTYTCMAQNKQKQTSRRNVEIQ 606
            .:..: |.:|| ....|:|   |.|...:|:|.::..|. :|||.|||:..|........:..:.
Mouse   255 ANLTYSWFQDGVNVFHISRLQSRVRILVDGSLWLQATQP-DDAGHYTCVPSNGFLHPPSASAYLT 318

  Fly   607 VLVPPK--IMPIQAMTNMLREGMRAAISCQILEGDLPVSF-RWERNGKPLIGTGNEVFRRLDEY- 667
            ||.|.:  :||.:   ..|..|||..|.|.: ..:.|:.| .|.::|:.|         :||::
Mouse   319 VLYPAQVTVMPPE---TPLPTGMRGVIRCPV-RANPPLLFVTWTKDGQAL---------QLDKFP 370

  Fly   668 ------SASLVIEHISSDHSGNYTCIASNVAGTERFTVPLT---VNVPPKWILEPKDSSAQ-AGA 722
                  ..||:|...:.:..|.|:|...|..||.. ..|:|   :..||.:|.:||:...| .|.
Mouse   371 GWSLGPEGSLIIALGNENALGEYSCTPYNSLGTAG-PSPVTQVLLKAPPAFIDQPKEEYFQEVGR 434

  Fly   723 DVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKKISKESQGHFLCEAKN 787
            ::|:.|.:.|.|.|.::|.|......|:         .|:..|.::..:.::||:||.:.|.|.|
Mouse   435 ELLIPCSARGDPPPIVSWAKVGRGLQGQ---------AQVDSNNSLVLRPLTKEAQGRWECSASN 490

  Fly   788 NIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLD 852
            .:....:......:....|..|....:.:.||..|              .|         :...|
Mouse   491 AVARVTTSTNVYVLGTSPHVVTNVSVVPLPKGANV--------------SW---------EPGFD 532

  Fly   853 SRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQ 917
            ..|..|..|
Mouse   533 GGYLQRFSV-------------------------------------------------------- 541

  Fly   918 QSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQLRPAKA-YHIRMS 981
                    |..|.| ..|...:|.:......|  .|.||.:.|.|          |.| |...:.
Mouse   542 --------WYTPLA-KRPDRAHHDWVSLAVPI--GATHLLVPGLQ----------AHAQYQFSVL 585

  Fly   982 AENKLGASEFSEVV-----QVTTLEEVPSGPP-------------LAVRAEPKSSTEIFVTWDAP 1028
            |:||||:..|||:|     .:.|....|..||             :|||. |:.   :.:.||.|
Mouse   586 AQNKLGSGPFSEIVLSIPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRT-PRG---VLLHWDPP 646

  Fly  1029 ERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGE--TVLANLNKFTQYHVIV 1091
            |      ::.|...||.:    |.::  .:||:......|.   |.|  .::..|.|...|...:
Mouse   647 E------LIPGRLDGYIL----EGRQ--GSQGWEILDQGVA---GTEIQLLVPGLIKDVLYEFRL 696

  Fly  1092 QAYTSQGSGPPSK--EIAVQTMEDVPS 1116
            .|:.......||.  .|:...:|..||
Mouse   697 VAFADSYVSDPSNVANISTSGLEVYPS 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386	2/3 (67%)
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353	2/3 (67%)
		IgC2_3_Dscam	329..417	CDD:409549	26/121 (21%)
		Ig strand B	347..351	CDD:409549	1/3 (33%)
		Ig strand C	360..364	CDD:409549	0/3 (0%)
		Ig strand E	383..387	CDD:409549	1/3 (33%)
		Ig strand F	397..402	CDD:409549	2/17 (12%)
		Ig strand G	410..413	CDD:409549	0/2 (0%)
		IgI_4_Dscam	422..516	CDD:409548	25/93 (27%)
		Ig strand B	439..443	CDD:409548	2/3 (67%)
		Ig strand C	452..456	CDD:409548	1/3 (33%)
		Ig strand E	482..486	CDD:409548	0/3 (0%)
		Ig strand F	496..501	CDD:409548	3/4 (75%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	25/92 (27%)
		Ig strand B	536..540	CDD:409550	0/3 (0%)
		Ig strand C	549..553	CDD:409550	0/4 (0%)
		Ig strand E	571..575	CDD:409550	2/3 (67%)
		Ig strand F	586..591	CDD:409550	3/4 (75%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	27/105 (26%)
		Ig strand A	611..613	CDD:409353	0/3 (0%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	4/8 (50%)
		Ig strand C	641..648	CDD:409353	3/7 (43%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	0/4 (0%)
		Ig strand E	668..675	CDD:409353	3/6 (50%)
		Ig strand F	682..690	CDD:409353	3/7 (43%)
		Ig strand G	693..702	CDD:409353	3/8 (38%)
		IgI_7_Dscam	706..801	CDD:409546	24/95 (25%)
		Ig strand B	724..728	CDD:409546	1/3 (33%)
		Ig strand C	737..741	CDD:409546	0/3 (0%)
		Ig strand E	766..770	CDD:409546	0/3 (0%)
		Ig strand F	780..785	CDD:409546	1/4 (25%)
		Ig strand G	794..797	CDD:409546	0/2 (0%)
		Ig	818..904	CDD:416386	8/85 (9%)
		putative Ig strand B	820..827	CDD:409353	1/6 (17%)
		putative Ig strand C	835..841	CDD:409353	1/5 (20%)
		putative Ig strand C'	853..856	CDD:409353	0/2 (0%)
		putative Ig strand D	862..866	CDD:409353	0/3 (0%)
		putative Ig strand E	868..874	CDD:409353	0/5 (0%)
		putative Ig strand F	881..889	CDD:409353	0/7 (0%)
		putative Ig strand G	892..902	CDD:409353	0/9 (0%)
		FN3	906..999	CDD:238020	23/98 (23%)
		FN3	1006..1110	CDD:238020	26/120 (22%)
		fn3	1117..1203	CDD:394996	197/872 (23%)
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Igsf9	NP_001139272.1	IG_like	28..110	CDD:214653	22/82 (27%)
		Ig	136..223	CDD:386229	26/100 (26%)
		Ig_3	227..305	CDD:372822	24/78 (31%)
		Ig	341..404	CDD:386229	17/72 (24%)
		Ig	436..500	CDD:319273	17/72 (24%)
		FN3	508..599	CDD:238020	32/190 (17%)
		FN3	625..715	CDD:238020	24/108 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..807
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..842
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810