DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam4 and PAPLN

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_001352835.1 Gene:PAPLN / 89932 HGNCID:19262 Length:1278 Species:Homo sapiens


Alignment Length:427 Identity:109/427 - (25%)
Similarity:168/427 - (39%) Gaps:117/427 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   391 QKEDPG-----MYQCFVSNEW---EQIQSTAELQLGDA-SP-----ELLYWFSEQTLQP------ 435
            |.:.||     ..|.|  .||   :::.|.|....||| ||     ...|..|...::|      
Human   860 QDQQPGPGEAPHTQAF--GEWPWGQELGSRAPGLGGDAGSPAPPFHSS
SYRISLAGVEPSLVQAA 922

  Fly   436 -GPTVSLKCVATGNPLPQFTWSLDGFPI-PDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYT 498
             |..|.|.|.....|..|..|..||.|| .|..|......:.||.          ::.||.|.|:
Human   923 LGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHP----------LQAEDAGTYS 977

  Fly   499 CTAQNAIGKVSHSAKVNIYG-------------LPYIRE-------------------------- 524
            |.:... |:.|...::.|.|             .|..|:                          
Human   978 C
GSTRP-GRDSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPAN 1041

  Fly   525 -------MPKITGIS-GSDLIVKCPVAGYPIDKIHWERDGQTLPINR-RQRAYNNGTLIIEQLQR 580
                   .|::...| |..:.:.|...|:|...|.|:||||  |::. |.:...:|:|:|.:: .
Human  1042 RLRLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQ--PVSSPRHQLQPDGSLVISRV-A 1103

  Fly   581 LEDAGTYTCMAQNKQKQTSRRNVEIQVL-------VPPKIMPIQAMTNMLREGMRAAISCQILEG 638
            :||.|.|||:|.|.|.: .:|.|:::||       :||        |..:.||..|.:.| ::.|
Human  1104 VEDGGFYTCVAFNGQDR-DQRWVQLRVLGELTISGLPP--------TVTVPEGDTARLLC-VVAG 1158

  Fly   639 DLPVSFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTV 703
            : .|:.||.|||.|:...|:.|.:..|   .:|:|.::.:...|:|||  |...|::..:....|
Human  1159 E-SVNIRWSRNGLPVQADGHRVHQSPD---GTLLIYNLRARDEGSYTC--SAYQGSQAVSRSTEV 1217

  Fly   704 N-VPPKWILEPKDSSAQ-------AGADVLLHCQSSG 732
            . |.|....:|:|....       |..|::|..|..|
Human  1218 KVVSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCG 1254

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand D 75..78 CDD:409353
Ig strand E 83..88 CDD:409353
Ig strand F 101..109 CDD:409353
Ig strand G 112..124 CDD:409353
Ig 235..326 CDD:416386
Ig strand A 235..238 CDD:409353
Ig strand A' 244..248 CDD:409353
Ig strand B 251..258 CDD:409353
Ig strand C 266..271 CDD:409353
Ig strand C' 276..279 CDD:409353
Ig strand D 285..289 CDD:409353
Ig strand E 292..298 CDD:409353
Ig strand F 305..313 CDD:409353
Ig strand G 316..326 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 9/33 (27%)
Ig strand B 347..351 CDD:409549
Ig strand C 360..364 CDD:409549
Ig strand E 383..387 CDD:409549
Ig strand F 397..402 CDD:409549 1/4 (25%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 26/106 (25%)
Ig strand B 439..443 CDD:409548 2/3 (67%)
Ig strand C 452..456 CDD:409548 1/3 (33%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 1/2 (50%)
IgI_5_Dscam 520..607 CDD:409550 30/121 (25%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 1/3 (33%)
Ig strand E 571..575 CDD:409550 2/3 (67%)
Ig strand F 586..591 CDD:409550 3/4 (75%)
Ig strand G 600..603 CDD:409550 1/2 (50%)
Ig 610..703 CDD:416386 26/92 (28%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 1/3 (33%)
Ig strand B 627..636 CDD:409353 2/8 (25%)
Ig strand C 641..648 CDD:409353 3/6 (50%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 1/4 (25%)
Ig strand E 668..675 CDD:409353 2/6 (33%)
Ig strand F 682..690 CDD:409353 4/7 (57%)
Ig strand G 693..702 CDD:409353 1/8 (13%)
IgI_7_Dscam 706..801 CDD:409546 8/34 (24%)
Ig strand B 724..728 CDD:409546 1/3 (33%)
Ig strand C 737..741 CDD:409546
Ig strand E 766..770 CDD:409546
Ig strand F 780..785 CDD:409546
Ig strand G 794..797 CDD:409546
Ig 818..904 CDD:416386
putative Ig strand B 820..827 CDD:409353
putative Ig strand C 835..841 CDD:409353
putative Ig strand C' 853..856 CDD:409353
putative Ig strand D 862..866 CDD:409353
putative Ig strand E 868..874 CDD:409353
putative Ig strand F 881..889 CDD:409353
putative Ig strand G 892..902 CDD:409353
FN3 906..999 CDD:238020
FN3 1006..1110 CDD:238020
fn3 1117..1203 CDD:394996
FN3 1215..1307 CDD:238020
Ig <1334..1401 CDD:416386
Ig strand C 1345..1349 CDD:409353
Ig strand D 1363..1366 CDD:409353
Ig strand E 1367..1372 CDD:409353
Ig strand F 1380..1388 CDD:409353
Ig strand G 1394..1401 CDD:409353
FN3 1405..1494 CDD:238020
FN3 1499..1580 CDD:238020
PAPLNNP_001352835.1 TSP1 29..80 CDD:214559
ADAM_spacer1 183..298 CDD:310520
TSP1 308..361 CDD:214559
TSP1 369..424 CDD:214559
TSP1 424..481 CDD:214559
TSP1 488..539 CDD:214559
Kunitz_BPTI 753..805 CDD:278443
Papilin_u7 814..905 CDD:318767 14/46 (30%)
Ig 914..>978 CDD:325142 20/73 (27%)
I-set 1049..1119 CDD:254352 25/72 (35%)
IG 1139..1219 CDD:214652 27/94 (29%)
PLAC 1235..1267 CDD:312271 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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