DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam4 and KIRREL3

DIOPT Version :9

Sequence 1:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	858	Identity:	182/858 - (21%)
Similarity:	291/858 - (33%)	Gaps:	264/858 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 LYWFS----EQTLQPGPTVSLKCVATGNPLPQFTWSLDGFP--IPDSSRFLVG-------QYVTI 476
            :|.||    :|.:..|..|:|.|.     :|::    |||.  |.|.....||       ||:.:
Human    53 VYSFSQQPQDQVVVSGQPVTLLCA-----IPEY----DGFVLWIKDGLALGVGRDLSSYPQYLVV 108

  Fly   477 --HDDVISHVNISNVKEEDGGEYTCTA-QNAIGKVSHSAKVNIY---GLPYIREMPKITGISGSD 535
              |.....|:.|...:.:|...|.|.| |.||.  |..|::.:.   ..|.|...|.|:..:|..
Human   109 GNHLSGEHHLKILRAELQDDAVYECQAIQAAIR--SRPARLTVLVPPDDPVILGGPVISLRAGDP 171

  Fly   536 LIVKCPV-AGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQR-----------------LE 582
            |.:.|.. ...|...|.|.|.|:.:          ||....:.|.|                 :|
Human   172 LNLTCHADNAKPAASIIWLRKGEVI----------NGATYSKTLLRDGKRESIVSTLFISPGDVE 226

  Fly   583 DAGTYTCMAQNKQ----KQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVS 643
            :..:..|.|.||.    |:||   |.|.:..|| ::.:......:.|.......|..........
Human   227 NGQSIVCRATNKAIPGGKETS---VTIDIQHPP-LVNLSVEPQPVLEDNVVTFHCSAKANPAVTQ 287

  Fly   644 FRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPK 708
            :||.:.|:.:.....||:|...:|:.          .|...:|..:|..|:...:..:.|...|:
Human   288 YRWAKRGQIIKEASGEVYRTTVDYTY----------FSEPVSCEVTNALGSTNLSRTVDVYFGPR 342

  Fly   709 WILEPKDSSAQAGADVLLHCQSSGYPTPTITW-KKAIGPTPGEYKDFLYEPTVQLFPNGTIFFKK 772
            ...||:......|:|.:..|..:|.|:.||.| |:..|              |.|....|:..|.
Human   343 MTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSG--------------VVLSNEKTLTLKS 393

  Fly   773 ISKESQGHFLCEA-KNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDNPID- 835
            :.:|..|.::|.| ...:|:| .:.:.|.||.|....:...|.:: .|::..::|.::...|.|
Human   394 VRQEDAGKYVCRAVVPRVGAG-EREVTLTVNGPPIISSTQTQHAL-HGEKGQIKCFIRSTPPPDR 456

  Fly   836 --FKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQD-TGIYICQASNAFGQDEMS 897
              :.||    :..|:.....|||:.....::|::|.|.||:..|.| ..||.|.|.|:||.|...
Human   457 IAWSWK----ENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEI 517

  Fly   898 IQLIVQ-------------EVP------------------------------------------- 906
            |:|..|             .||
Human   518 IRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRSTGGRSGISGR 582

  Fly   907 --EQPKNLR----------INSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIA 959
              |:...||          ::::....:::...:|.:|.                 :..||.||
Human   583 GTEKKARLRLPRRANLKGVVSAKNDIRVEIVHKEPASGR-----------------EGEEHSTI- 629

  Fly   960 GAQTVIN---IQQLRPAKAYHIRMSAENKLGASEFSEV-------VQVTTLEEVPSGPPLAVRAE 1014
             .|.:::   .||....|...: :..|.|    ||..:       ..|.|.:|..|.|.:::.:
Human   630 -KQLMMDRGEFQQDSVLKQLEV-LKEEEK----EFQNLKDPTNGYYSVNTFKEHHSTPTISLSS- 687

  Fly  1015 PKSSTEIFVTWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLA 1079
                                         .|..|.|..|:..|| |.||  ..:.|...|:   .
Human   688 -----------------------------CQPDLRPAGKQRVPT-GMSF--TNIYSTLSGQ---G 717

  Fly  1080 NLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPES---PQCDVLGSTSIYITWSPPDI 1141
            .|..:.|..|:       |.|..|.|:..:..:....|...|   .|||...|:|
Human   718 RLYDYGQRFVL-------GMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSS---------- 765

  Fly  1142 DGQNGKIKGYKVF 1154
                ||..||..|
Human   766 ----GKQDGYVQF 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549
		Ig strand F	397..402	CDD:409549
		Ig strand G	410..413	CDD:409549
		IgI_4_Dscam	422..516	CDD:409548	30/106 (28%)
		Ig strand B	439..443	CDD:409548	2/3 (67%)
		Ig strand C	452..456	CDD:409548	0/3 (0%)
		Ig strand E	482..486	CDD:409548	1/3 (33%)
		Ig strand F	496..501	CDD:409548	2/4 (50%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	26/108 (24%)
		Ig strand B	536..540	CDD:409550	1/3 (33%)
		Ig strand C	549..553	CDD:409550	1/3 (33%)
		Ig strand E	571..575	CDD:409550	1/3 (33%)
		Ig strand F	586..591	CDD:409550	1/4 (25%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	15/92 (16%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	1/8 (13%)
		Ig strand C	641..648	CDD:409353	2/6 (33%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	3/4 (75%)
		Ig strand E	668..675	CDD:409353	0/6 (0%)
		Ig strand F	682..690	CDD:409353	1/7 (14%)
		Ig strand G	693..702	CDD:409353	1/8 (13%)
		IgI_7_Dscam	706..801	CDD:409546	24/96 (25%)
		Ig strand B	724..728	CDD:409546	0/3 (0%)
		Ig strand C	737..741	CDD:409546	3/4 (75%)
		Ig strand E	766..770	CDD:409546	1/3 (33%)
		Ig strand F	780..785	CDD:409546	1/4 (25%)
		Ig strand G	794..797	CDD:409546	0/2 (0%)
		Ig	818..904	CDD:416386	28/102 (27%)
		putative Ig strand B	820..827	CDD:409353	0/6 (0%)
		putative Ig strand C	835..841	CDD:409353	3/8 (38%)
		putative Ig strand C'	853..856	CDD:409353	1/2 (50%)
		putative Ig strand D	862..866	CDD:409353	0/3 (0%)
		putative Ig strand E	868..874	CDD:409353	3/5 (60%)
		putative Ig strand F	881..889	CDD:409353	4/7 (57%)
		putative Ig strand G	892..902	CDD:409353	4/9 (44%)
		FN3	906..999	CDD:238020	19/157 (12%)
		FN3	1006..1110	CDD:238020	19/103 (18%)
		fn3	1117..1203	CDD:394996	12/41 (29%)
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	27/101 (27%)
		IG_like	60..149	CDD:214653	27/99 (27%)
		I-set	156..249	CDD:254352	24/105 (23%)
		Ig2_KIRREL3-like	171..252	CDD:143236	21/93 (23%)
		Ig_2	260..337	CDD:290606	13/86 (15%)
		I-set	341..422	CDD:254352	24/95 (25%)
		IGc2	355..406	CDD:197706	17/64 (27%)
		Ig5_KIRREL3	424..521	CDD:143306	28/101 (28%)
		IG_like	432..521	CDD:214653	27/93 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10991
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810