DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam4 and USH2A

DIOPT Version :9

Sequence 1:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:2129 Identity:427/2129 - (20%)
Similarity:683/2129 - (32%) Gaps:740/2129 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 RAETSQFVNGLDLQGPIFLHEPPHRVEFS-----NNSGGLIECSGH-----GSPPP--------- 62
            |:.:.:|::......|...:|  :||..|     .||...:|.:..     |..||         
Human  2677 RSHSMRFIDKTSALSPWTKYE--YRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDA 2739

  Fly    63 -EVEWTPIPPQQDMVFQLSNGSMMFYPFTAEKYRHEVHATVYRCKLRNLVGTVLSREVHVRGVVN 126
             :|.|.  ||      .:.||.::.|         |:|.......|.|:...|||::|       
Human  2740 VQVTWK--PP------LIQNGDILSY---------EIHMPDPHITLTNVTSAVLSQKV------- 2780

  Fly   127 QKYAVQVHDEYVMTGNTAVLKCQVPSYMSEFVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGELYI 191
                                                      .||.|.|:........|.|..|:
Human  2781 ------------------------------------------THLIPFTNYSVTIVACSGGNGYL 2803

  Fly   192 NNAGPNDAYKSYTCRTVNRLTGEVQISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLP 256
              .|..::..:|             ::|:|     |.|:. |.| ::|...|..:||::.|   |
Human  2804 --GGCTESLPTY-------------VTTHP-----TVPQN-VGP-LSVIPLSESYVVISWQ---P 2843

  Fly   257 CIAQGHPVPTYRWFKEENEQLL----PLQLSERITIVSAGLLKITKARLEDSG-------KYLCW 310
            ......|...|...:.:.:|.|    |..|:....|.|.     |:...||.|       :|:.:
Human  2844 PSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSG-----TQWLYEDKGLSRFTTYEYMLF 2903

  Fly   311 VNNTAG-EETIQVSLTVTAPLTAHLQPQVQTVDVDKDAQFQCIVSGHPVHDVNWLHDGKPILRD- 373
            |:|:.| ..:.:|::|..|.|.            ::.|.....|..|...||.|   .||.::| 
Human  2904 VHNSVGFTPSREVTVTTLAGLP------------ERGANLTASVLNHTAIDVRW---AKPTVQDL 2953

  Fly   374 -----------------NRVEILTDPPRLIIKKVQKEDPGMYQCFVS--NEWEQIQST------- 412
                             :.::||.|....:|..::....  |..|:|  |....|.|.       
Human  2954 QGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTE--YWIFISVFNGVHSINSAGLHATTC 3016

  Fly   413 -AELQLGDASPEL---------LYWFSEQTLQPGPTVSLKCVATGNPLPQFTWSLDG-FPIPDSS 466
             .|.| |...||:         :.|.|..  .|...|:...:...|.|.:...::.| |.:.|.|
Human  3017 DGEPQ-GMLPPEVVIINSTAVRVIWTSPS--NPNGVVTEYSIYVNNKLYKTGMNVPGSFILRDLS 3078

  Fly   467 RFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLPYIREMPKITGI 531
            .|      ||:|..:....|          |.|...|.      :....:...|.....|.|.||
Human  3079 PF------TIYDIQVEVCTI----------YACVKSNG------TQITTVEDTPSDIPTPTIRGI 3121

  Fly   532 SGSDLIV-----KCP---VAGYPIDKIHWERDGQTLPINRRQRAYNNGTLIIEQLQRLEDAGTYT 588
            :...|.:     :.|   :.||.:....|      .|..:.|:      |:.:|...|       
Human  3122 TSRSLQIDWVSPRKPNGIILGYDLLWKTW------YPCAKTQK------LVQDQSDEL------- 3167

  Fly   589 CMAQNKQKQTS-------RRNVEI---QVLVPP---------KIMPIQAMTNMLREGMR------ 628
            |.|...||..|       ....::   .||..|         |.:|....:..:..|.|      
Human  3168 CKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQP 3232

  Fly   629 -----AAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIA 688
                 :....:||.|:  |....|::.:..:|.|:....|: .||.           |||..|.|
Human  3233 NHQCCSGYYARILPGE--VCCPDEQHNRVSVGIGDSCCGRM-PYST-----------SGNQICCA 3283

  Fly   689 SNVAGTERFTVPLTVNVPPKWILEPKDSSAQ--AGADVL---LHCQSSGYPTPTITWKKAIGPTP 748
            ..:                      .|...|  .|..::   |.|                   .
Human  3284 GRL----------------------HDGHGQKCCGRQIVSNDLEC-------------------C 3307

  Fly   749 GEYKDFLYEPTVQLFPNG--------TIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPA 805
            |..:..:|.....:|..|        ||.....|.||:.|                  :|.|.|.
Human  3308 GGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAH------------------IKKNDPV 3354

  Fly   806 HFQTKTKQISVAKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSEL 870
            ..:....:: :.|.::.   ||..|.||:                   :|...|::....|:.| 
Human  3355 PVKCCETEL-IPKSQKC---CNGVGYNPL-------------------KYVCSDKISTGMMMKE- 3395

  Fly   871 GISHTYRQDTGIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFAGNSP 935
                  .::..| :|.||              .|..|.......|........:..|....|.:.
Human  3396 ------TKECRI-LCPAS--------------MEATEHCGRCDFNFTSHICTVIRGSHNSTGKAS 3439

  Fly   936 IEEYHIYYKQISDIWQNAEHLTIAG-----AQTVINIQQLRPAKAYHIRMSAENKLGASEFSEVV 995
            |||          :..:||.....|     :.|.:|   |:|...|..|:||.|..|.. .|:.|
Human  3440 IEE----------MCSSAEETIHTGSVNTYSYTDVN---LKPYMTYEYRISAWNSYGRG-LSKAV 3490

  Fly   996 QVTTLEEVPSG--PPLAVRAEPKSSTEIFVTWDAPERDHWNGILLGYYV----GYQ----MSLTP 1050
            :..|.|:||.|  ||...:.:....| |.:.|..|.:.  ||.:: ||:    |.:    .||:.
Human  3491 RARTKEDVPQGVSPPTWTKIDNLEDT-IVLNWRKPIQS--NGPII-YYILLRNGIERFRGTSLSF 3551

  Fly  1051 EDKE-VNPTQGFSFKTVEVRSHFGGETVLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDV 1114
            .||| :.|.|.:|::                          ::|.|..|....||.:|. |.:.|
Human  3552 SDKEGIQPFQEYSYQ--------------------------LKACTVAGCATSSKVVAA-TTQGV 3589

  Fly  1115 PSS--PPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYVT 1177
            |.|  |   |....|.:.:::::||.|  :..||.||.|::..:. ..|..||    .:..:..|
Human  3590 PESILP---PSITALSAVALHLSWSVP--EKSNGVIKEYQIRQVG-KGLIHTD----TTDRRQHT 3644

  Fly  1178 IENLRKYTNYTVWVLAYTKVGDGMKTKPFYCRTHEDVPSAPQAIKAIP----ASSSKIIISWLPP 1238
            :..|:.||||:..:.|.|..| ...::||..:|   :.:||:.:...|    .:|:.:.:.|..|
Human  3645 VTGLQPYTNYSFTLTACTSAG-CTSSEPFLGQT---LQAAPEGVWVTPRHIIINSTTVELYWSLP 3705

  Fly  1239 DLPNGDITGYTFYMS---MLEGGREEG--THKRLLGPFVEMHETVRTQESATYQFWLTASTKMGE 1298
            :.|||.::.|....:   :..||.||.  |.|.|             :.::.|.:.|...|..|.
Human  3706 EKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNL-------------EPNSRYTYKLEVKTGGGS 3757

  Fly  1299 GEKTQVVTVPPNNKVPARIVSFSQRIVTPWKEHL----------ELPCR-----KVGAPAPVTIW 1348
            ......:...|.:........::..::.|:...:          |:|..     ..|:..|:.. 
Human  3758 SASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAF- 3821

  Fly  1349 RQDGHNMETSARKTIAKNGT------LYMKECQASDAGNYTCSVENTWGKDEIVYNIVVKVPPEA 1407
             ..||:     :.|:.:|.|      :.::.||     |.:|.|.:         .:.||.|..|
Human  3822 -SVGHH-----QSTLLENLTPFTQYEIRIQACQ-----NGSCGVSS---------RMFVKTPEAA 3866

  Fly  1408 P---NLTVINAYTDSLL-LEWMDNSHGGSPILGYVINYKRDNGDWEE--LQVDSKTTSHLL---T 1463
            |   |..|:.|...:.: ::||........|:.|.| |:|..|..||  |.|.|:.....:   .
Human  3867 PMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFI-YRRPAGIEEESVLFVWSEGALEFMDEGD 3930

  Fly  1464 NLWCGTRYQLYITAYNKIGTGLPCDIVNS-----YTKGNPPVQ-PKHSQMITNNSTSVTCWLDSW 1522
            .|...|.|:..:.|.|..|:      |.|     .|...||.. |......|:..:.:..|... 
Human  3931 TLRPFTLYEYRVRACNSKGS------VESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKP- 3988

  Fly  1523 GDGGCGILYFMIESRVYGRSSWAVVSNHIP-------PTERIYTVS---------DLVPGTKYQL 1571
             :...||:           |.:.||....|       ||...:||.         .|.|.|.|::
Human  3989 -ESPNGII-----------SHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRI 4041

  Fly  1572 KVTAHNNAG--------------STTAIYNFTT----------------LSTQGVIYN-NDHSTP 1605
            .|.|.|:||              |.:.:.||..                :.|.|||.. |..|..
Human  4042 GVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDG 4106

  Fly  1606 VSHLSDLPFYANFKLLLPICFSLLMLLALIGAALF------LRKRKLASQARLASS-----SMSE 1659
            ....|.|.....|:.|.|.....|.|.|...|...      |...:....::||.:     |.|.
Human  4107 FLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSV 4171

  Fly  1660 SPSLANLQNKQNRDQQYLAV-RCNPGTSAPRGSNSNDSGSFGKAEGNEYIE-DICPYATFQLNKQ 1722
            ..|.:...|...:..:|..: ||..                |||.||:.|: |         .|.
Human  4172 ELSWSEPVNPNGKIIRYEVIRRCFE----------------GKAWGNQTIQAD---------EKI 4211

  Fly  1723 TYSESSYSGNVYSGPYHSVRGSFVYHDVKPESYHSKEPEYTKVRRKVGRLRDPHSESQESDNPGS 1787
            .::|           |::.|.:|:|:|.      ..:| :|:...|:          ...::.|.
Human  4212 VFTE-----------YNTERNTFMYNDT------GLQP-WTQCEYKI----------YTWNSAGH 4248

  Fly  1788 TDSEVRKILTLHI-------PITEYDTLG----------SESDNDVSARALNSAKYRAQRD---- 1831
            |.|....:.||..       |:..|.::.          .|..|.:      ...||.||:    
Human  4249 TCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGI------IQSYRLQRNEMLY 4307

  Fly  1832 -----------TQDE--------------TSSSSETT-PTSMTRKSKPP 1854
                       |.:|              ||....|: |||:|.....|
Human  4308 PFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAP 4356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 26/112 (23%)
Ig strand A 32..35 CDD:409353 1/2 (50%)
Ig strand A' 41..45 CDD:409353 2/3 (67%)
Ig strand B 48..57 CDD:409353 2/8 (25%)
Ig strand D 75..78 CDD:409353 0/2 (0%)
Ig strand E 83..88 CDD:409353 0/4 (0%)
Ig strand F 101..109 CDD:409353 1/7 (14%)
Ig strand G 112..124 CDD:409353 4/11 (36%)
Ig 235..326 CDD:416386 24/102 (24%)
Ig strand A 235..238 CDD:409353 1/2 (50%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 2/6 (33%)
Ig strand C 266..271 CDD:409353 1/4 (25%)
Ig strand C' 276..279 CDD:409353 2/6 (33%)
Ig strand D 285..289 CDD:409353 0/3 (0%)
Ig strand E 292..298 CDD:409353 0/5 (0%)
Ig strand F 305..313 CDD:409353 3/14 (21%)
Ig strand G 316..326 CDD:409353 2/10 (20%)
IgC2_3_Dscam 329..417 CDD:409549 21/115 (18%)
Ig strand B 347..351 CDD:409549 1/3 (33%)
Ig strand C 360..364 CDD:409549 2/3 (67%)
Ig strand E 383..387 CDD:409549 0/3 (0%)
Ig strand F 397..402 CDD:409549 1/4 (25%)
Ig strand G 410..413 CDD:409549 1/10 (10%)
IgI_4_Dscam 422..516 CDD:409548 20/103 (19%)
Ig strand B 439..443 CDD:409548 1/3 (33%)
Ig strand C 452..456 CDD:409548 0/3 (0%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 2/4 (50%)
Ig strand G 509..512 CDD:409548 0/2 (0%)
IgI_5_Dscam 520..607 CDD:409550 20/104 (19%)
Ig strand B 536..540 CDD:409550 1/8 (13%)
Ig strand C 549..553 CDD:409550 0/3 (0%)
Ig strand E 571..575 CDD:409550 1/3 (33%)
Ig strand F 586..591 CDD:409550 1/4 (25%)
Ig strand G 600..603 CDD:409550 0/2 (0%)
Ig 610..703 CDD:416386 20/112 (18%)
Ig strand A 611..613 CDD:409353 1/10 (10%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 1/19 (5%)
Ig strand C 641..648 CDD:409353 1/6 (17%)
Ig strand C' 650..652 CDD:409353 0/1 (0%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 1/6 (17%)
Ig strand F 682..690 CDD:409353 4/7 (57%)
Ig strand G 693..702 CDD:409353 0/8 (0%)
IgI_7_Dscam 706..801 CDD:409546 15/107 (14%)
Ig strand B 724..728 CDD:409546 1/6 (17%)
Ig strand C 737..741 CDD:409546 0/3 (0%)
Ig strand E 766..770 CDD:409546 3/11 (27%)
Ig strand F 780..785 CDD:409546 1/4 (25%)
Ig strand G 794..797 CDD:409546 0/2 (0%)
Ig 818..904 CDD:416386 14/85 (16%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 0/5 (0%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 0/3 (0%)
putative Ig strand E 868..874 CDD:409353 1/5 (20%)
putative Ig strand F 881..889 CDD:409353 3/7 (43%)
putative Ig strand G 892..902 CDD:409353 0/9 (0%)
FN3 906..999 CDD:238020 22/97 (23%)
FN3 1006..1110 CDD:238020 26/114 (23%)
fn3 1117..1203 CDD:394996 24/87 (28%)
FN3 1215..1307 CDD:238020 21/100 (21%)
Ig <1334..1401 CDD:416386 13/77 (17%)
Ig strand C 1345..1349 CDD:409353 0/3 (0%)
Ig strand D 1363..1366 CDD:409353 0/2 (0%)
Ig strand E 1367..1372 CDD:409353 1/10 (10%)
Ig strand F 1380..1388 CDD:409353 3/7 (43%)
Ig strand G 1394..1401 CDD:409353 0/6 (0%)
FN3 1405..1494 CDD:238020 26/102 (25%)
FN3 1499..1580 CDD:238020 21/97 (22%)
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012
EGF_Lam 950..1000 CDD:238012
EGF_Lam 1001..>1037 CDD:238012
fn3 1058..1132 CDD:394996
fn3 1150..1227 CDD:394996
FN3 1242..1357 CDD:238020
FN3 1368..1451 CDD:214495
LamG 1519..1678 CDD:238058
LamG 1716..1868 CDD:238058
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020 10/43 (23%)
FN3 2724..2799 CDD:238020 23/140 (16%)
FN3 2818..2920 CDD:238020 28/116 (24%)
FN3 2925..3015 CDD:238020 19/106 (18%)
FN3 3026..>3087 CDD:238020 16/68 (24%)
FN3 <3449..3494 CDD:238020 13/48 (27%)
FN3 3503..3586 CDD:238020 25/113 (22%)
FN3 3590..3676 CDD:238020 27/96 (28%)
FN3 3680..3767 CDD:238020 21/99 (21%)
fn3 3777..3856 CDD:394996 15/90 (17%)
FN3 3866..3960 CDD:238020 26/100 (26%)
FN3 3964..4057 CDD:238020 24/105 (23%)
fn3 4161..4247 CDD:394996 24/138 (17%)
FN3 4268..4351 CDD:238020 16/88 (18%)
fn3 4357..4428 CDD:394996 427/2129 (20%)
FN3 4444..4516 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541
FN3 4529..4627 CDD:238020
FN3 4636..4730 CDD:238020
FN3 4826..4927 CDD:238020
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.